Tolypocladamide H and the Proposed Tolypocladamide NRPS in Tolypocladium Species. [PDF]
J Nat Prod, 2022 The genome of entomopathogenic fungus Tolypocladium inflatum Gams encodes 43 putative biosynthetic gene clusters for specialized metabolites, although genotype–phenotype linkages have been reported only for the cyclosporins and fumonisins. T.
Tehan RM +10 more
europepmc +2 more sources
A Review on Macrophage Activation Syndrome
Journal of Pure and Applied Microbiology, 2019 MAS, which is currently grouped under secondary or acquired haemophagocytic lymphohistiocytosis (sHLH), is a rare and fatal disorder that results from excess activation of T-cells and macrophages.
Preeti Sharma +4 more
doaj +1 more source
Differential inhibition by cyclosporins of primary-active ATP-dependent transporters in the hepatocyte canalicular membrane [PDF]
, 1993 The distinct ATP-dependent transporters for taurocholate, leukotriene C4, and daunorubicin, studied in rat liver canalicular membrane vesicles, are sensitive to inhibition by cyclosporin A and its non-immunosuppressive analog PSC 833.
Markus Büchler +7 more
core +1 more source
Backbone Steric Constraints Underlie High Passive Membrane Permeability of N‐Alkyl Peptides
Angewandte Chemie, EarlyView.Beyond amide hydrogen removal, steric constraints encoded in N/Cα‐dually substituted backbones are uncovered as a key determinant of passive membrane permeability in N‐alkyl peptides. These constraints restrict conformational freedom and sterically limit backbone hydration during membrane permeation.
Ayumi Inayoshi +8 more
wiley +2 more sources
Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin A in phagocytes is not mediated by direct inhibition of protein kinase C [PDF]
, 1994 Cyclosporin A (CsA) has been reported to inhibit phorbol myristate acetate (PMA)-induced superoxide anion (O2-) formation in human neutrophils and murine macrophages.
Grünbaum, L. +4 more
core +1 more source
Type 1 diabetes in India: Overall insights
Indian Journal of Endocrinology and Metabolism, 2015 Type 1 diabetes mellitus (T1DM) is also on increase like type 2 diabetes, even though not in the same proportion, but still with a trend of 3-5% increase/year. India has three new cases of T1DM/100,000 children of 0-14 years.
Ashok Kumar Das
doaj +1 more source
Pitfall in the high-throughput quantification of whole blood cyclosporin A using liquid chromatography-tandem mass spectrometry [PDF]
, 2005 In a growing number of laboratories the technique of liquid chromatography-tandem mass spectrometry is used for the quantification of cyclosporin A in whole blood, employing cyclosporin D as the internal standard. Cyclosporin A is extensively metabolized
Michael Vogeser +3 more
core +2 more sources
Cyclosporin Structure and Permeability: From A to Z and Beyond
, 2021 Cyclosporins are natural or synthetic undecapeptides with a wide range of actual and potential pharmaceutical applications. Several members of the cyclosporin compound family have remarkably high passive membrane permeabilities that are not well ...
David K. Chalmers (1455451) +9 more
core +1 more source
CORRELATION OF BLOOD LEVELS OF CYCLOSPORINE AND IT'S METABOLITES AND LOCAL FACTORS WITH GINGIVAL OVERGROWTH IN IRANIAN RENAL ALLOGRAFT PATIENTS [PDF]
Acta Medica Iranica, 1997 Forty renal allograft patients with three months under immunosuppression by cycloserine were examined for their gingival overgrowth and it's correlation with several parameters including the trough levels of blood cyclosporine and it's ...
M. Sahebjamee . +4 more
doaj
Doubly Protonated Species Collision Induced Dissociation for Identification of Isocyclosporins [PDF]
, 2020 Nonribosomal cyclopeptide cyclosporin A (CsA), produced by fungus Tolypocladium inflatum, is an extremely important immunosuppressive drug used in organ transplantations and for therapy of autoimmune diseases. Here we report for the first time production
Mikhail, Biryukov +10 more
core +1 more source