Results 21 to 30 of about 1,270 (196)
Anais da Academia Brasileira de Ciências, 2001 Multidrug resistance to chemotherapy is a major obstacle in the treatment of cancer patients. The best characterised mechanism responsible for multidrug resistance involves the expression of the MDR-1 gene product, P-glycoprotein. However, the resistance
VIVIAN M. RUMJANEK +6 more
doaj +1 more source
Cross-reactivities of cyclosporin G (NVa2 cyclosporin) and metabolites in cyclosporin A immunoassays
Clinical Chemistry, 1993 Abstract Immunoassays of cyclosporin A (CsA) have been routinely used to measure CsG. We investigated the cross-reactivities of CsG and its metabolites, as well as the proportion CsG constitutes in relation to total drug measured, for six CsG metabolites (GM1, GM9, GM4N, GM1c, GM1c9, GM19) in the following CsA assays: Sandimmune ...
R W, Yatscoff, L J, Langman, D F, LeGatt
openaire +2 more sources
Complex of Cyclosporins Produced by Tolypocladium inflatum Isolated from Soil Sample of Buryatiya
Антибиотики и Химиотерапия, 2020 A micromycete culture was isolated from a soil sample of Buryatiya and identified as Tolypocladium inflatum No. 2. The culture was shown to produce a complex of cyclosporins ofunusual component structure: the content of cyclosporin A (55—60%) was the ...
M. V. Bibikova +4 more
doaj
Binding of active cyclosporins to cyclophilin A and B, complex formation with calcineurin A.
, 1993 The binding properties of several active and inactive cyclosporins to the major intracellular receptor proteins, cyclophilin A and B, as well as the interaction with the phosphatase calcineurin were investigated by ELISA and by means of a photoaffinity ...
Woerly G +4 more
core +1 more source
, 2016 The scope of isonitrile-mediated amide bond-forming reactions is further explored in this second-generation synthetic approach to cyclosporine (cyclosporin A).
Jennifer L. Stockdill (1308897) +3 more
core +1 more source
Molsidomine inhibits the chemoattractant-induced respiratory burst in human neutrophils via a no-independent mechanism [PDF]
, 1992 3-Morpholino-sydnonimine (SIN-1) is a NO-releasing compound which mimics the effects of cGMP through activation of soluble guanylyl cyclase. Its prodrug, molsidomine (SIN-10), does not release NO but does modulate various cell functions.
Seifert, Roland +3 more
core +1 more source
Solubilization of cyclosporin A [PDF]
AAPS PharmSciTech, 2001 This study investigated the solubilization of cyclosporin A (CsA), a neutral undecapeptide, by cosolvency, micellization, and complexation. Cosolvents (ethanol, propylene glycol, polyethylene glycol, tetrahydrofurfuryl alcohol polyethyleneglycol ether, and glycerin), surfactants (polyoxyethylene sorbitan monooleate [(Tween 80)], polyoxyethylene ...
Y, Ran, L, Zhao, Q, Xu, S H, Yalkowsky
openaire +2 more sources
Pediatric Investigation, EarlyView.This study elucidates the critical pathogenic mechanisms of pediatric Epstein–Barr virus‐associated hemophagocytic lymphohistiocytosis (EBV‐HLH), where EBV infection triggers a cytokine storm leading to immune cell hyperactivation and tissue damage. Dynamic plasma biomarkers (EBV‐DNA, ferritin, and interferon‐γ) effectively predict treatment response ...
Feifei Liu +9 more
wiley +1 more source
Phytotherapy Research, EarlyView.Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li +14 more
wiley +1 more source
Responsive Materials, EarlyView.Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan +8 more
wiley +1 more source