Results 21 to 30 of about 1,128 (166)
Type 1 diabetes in India: Overall insights
Indian Journal of Endocrinology and Metabolism, 2015 Type 1 diabetes mellitus (T1DM) is also on increase like type 2 diabetes, even though not in the same proportion, but still with a trend of 3-5% increase/year. India has three new cases of T1DM/100,000 children of 0-14 years.
Ashok Kumar Das
doaj +1 more source
Journal of Transplantation, 2012 The discovery and use of cyclosporine since its inception into clinical use in the late 1970s has played a major role in the advancement of transplant medicine. While it has improved rates of acute rejection and early graft survival, data on long-term survival of renal allografts is less convincing.
Dustin Tedesco, Lukas Haragsim
openaire +3 more sources
Backbone Steric Constraints Underlie High Passive Membrane Permeability of N‐Alkyl Peptides
Angewandte Chemie, EarlyView.Beyond amide hydrogen removal, steric constraints encoded in N/Cα‐dually substituted backbones are uncovered as a key determinant of passive membrane permeability in N‐alkyl peptides. These constraints restrict conformational freedom and sterically limit backbone hydration during membrane permeation.
Ayumi Inayoshi +8 more
wiley +2 more sources
CORRELATION OF BLOOD LEVELS OF CYCLOSPORINE AND IT'S METABOLITES AND LOCAL FACTORS WITH GINGIVAL OVERGROWTH IN IRANIAN RENAL ALLOGRAFT PATIENTS [PDF]
Acta Medica Iranica, 1997 Forty renal allograft patients with three months under immunosuppression by cycloserine were examined for their gingival overgrowth and it's correlation with several parameters including the trough levels of blood cyclosporine and it's ...
M. Sahebjamee . +4 more
doaj
Water‐Dispersible Ruthenium Nanocatalyst for Carbonyl Reduction With D2 or T2 in Aqueous Media
Angewandte Chemie, EarlyView.We report the synthesis and characterization of water‐dispersible ruthenium nanoparticles that catalyze the reductive deuteration and tritiation of carbonyl compounds in aqueous media, enabling efficient access to a broad range of isotopically labeled polar molecules, including cyclic peptides, antibody‐drug conjugate linkers, pegylated derivatives ...
Elisa Martinelli +6 more
wiley +2 more sources
Anais da Academia Brasileira de Ciências, 2001 Multidrug resistance to chemotherapy is a major obstacle in the treatment of cancer patients. The best characterised mechanism responsible for multidrug resistance involves the expression of the MDR-1 gene product, P-glycoprotein. However, the resistance
VIVIAN M. RUMJANEK +6 more
doaj +1 more source
Cross-reactivities of cyclosporin G (NVa2 cyclosporin) and metabolites in cyclosporin A immunoassays
Clinical Chemistry, 1993 Abstract Immunoassays of cyclosporin A (CsA) have been routinely used to measure CsG. We investigated the cross-reactivities of CsG and its metabolites, as well as the proportion CsG constitutes in relation to total drug measured, for six CsG metabolites (GM1, GM9, GM4N, GM1c, GM1c9, GM19) in the following CsA assays: Sandimmune ...
R W, Yatscoff, L J, Langman, D F, LeGatt
openaire +2 more sources
Cyclosporine Nephrotoxicity [PDF]
Toxicologic Pathology, 1986 Cyclosporine (CSA) is a new immunosuppressant which has selectivity for the immune system and is without systemic side effects at therapeutic doses. In contrast to the cytotoxic class of immunosuppressants, no myelotoxic, teratogenic, mutagenic, or carcinogenic effects were observed.
B, Ryffel, M J, Mihatsch
openaire +2 more sources
Complex of Cyclosporins Produced by Tolypocladium inflatum Isolated from Soil Sample of Buryatiya
Антибиотики и Химиотерапия, 2020 A micromycete culture was isolated from a soil sample of Buryatiya and identified as Tolypocladium inflatum No. 2. The culture was shown to produce a complex of cyclosporins ofunusual component structure: the content of cyclosporin A (55—60%) was the ...
M. V. Bibikova +4 more
doaj
Advanced Science, EarlyView.A multimodal intravital imaging platform enables longitudinal tracking of human cortical organoids transplanted into chronic stroke lesions. By combining surgical microscopy, MRI, bioluminescence imaging, and two‐photon fluorescence microscopy, the platform captures graft placement, viability dynamics, and cellular‐scale morphology in vivo, offering a ...
Jinghui Wang +12 more
wiley +1 more source