Results 41 to 50 of about 1,121 (159)
Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury
The Journal of Physiology, EarlyView.Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich +5 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic overview of a flow‐driven in vitro model of the human placental barrier designed to study transport processes during pregnancy. The model recreates key features of the maternal–fetal interface, enabling the investigation of how nutrients and therapeutic compounds cross the placental barrier under physiologically ...
Barbara Fuenzalida +7 more
wiley +1 more source
SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia
The Journal of Physiology, EarlyView.Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu +5 more
wiley +1 more source
Cleveland Clinic Journal of Medicine, 1989 Cyclosporine is a potent and useful immunosuppressive agent used primarily in conjunction with solid organ transplantation. The most serious adverse reaction that limits its use is nephrotoxicity due to effects on the renal vasculature, glomeruli, and tubular function. These effects result in a variety of clinical syndromes.
openaire +2 more sources
Lethal and Sublethal Toxicity Assessment of Cyclosporin C (a Fungal Toxin) against Plutella xylostella (L.). [PDF]
Toxins (Basel), 2022 Wu J, Zhang X, Bashir MH, Ali S.
europepmc +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács +8 more
wiley +1 more source
AlphaFold2‐Guided Cyclic Peptide Stabilizer Design to Target Protein–Protein Interactions
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 7, Page 1356-1370, July 2026.ABSTRACT The control and modulation of protein–protein interactions (PPIs) is of central importance for the majority of biological processes and most biomedical applications. Stabilization of PPIs, besides inhibition, is of growing pharmaceutical interest.
Niklas Halbwedl, Martin Zacharias
wiley +1 more source
Journal of Neurochemistry, Volume 170, Issue 7, July 2026.Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the midbrain. Cell transplantation, which aims to replace these lost neurons, has emerged as a promising approach. Early attempts using fetal ventral mesencephalic tissue showed proof‐of‐concept, with some patients achieving long‐term motor improvement. However,
Etsuro Nakanishi +4 more
wiley +1 more source
Experimenteller Nachweis der metallbezogenen Funktion eines Cyanobactins
Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.Patellamide (Cyanobactine) werden von einer cyanobakteriellen Spezies in grosser Menge hergestellt. Diese zyklischen Peptide wurden in der Vergangenheit fast ausschliesslich auf ihre cytotoxischen Eigenschaften untersucht. Wir diskutieren neue experimentelle Daten, die auf eine Metallionen‐abhängige biologische Funktion der Patellamide schliessen ...
Philipp Baur +8 more
wiley +1 more source
What Is Your Diagnosis? Cutaneous Mass in a Dog
Veterinary Clinical Pathology, EarlyView.
Ester Quilez, Shannon L. Donahoe
wiley +1 more source