Results 211 to 220 of about 5,815 (271)
Comparative Ecotoxicological Effects of Cyanobacterial Crude Extracts on Native Tropical Cladocerans and <i>Daphnia magna</i>. [PDF]
Toxins (Basel)Zamora-Barrios CA +3 more
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The rediscovery of HepG2 cells for prediction of drug induced liver injury (DILI) [PDF]
, 2014 Ghallab, Ahmed
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Teratogenicity, cardiac toxicity, neurotoxicity and genotoxicity in zebrafish embryo-larvae exposed to 4-bromodiphenyl ether. [PDF]
Toxicol Res (Camb)Kumar S, Chadha P.
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Alterations in acetylcholinesterase activity and oxidative stress parameters induced by pure cylindrospermopsin in brain of orally exposed rats and determination of potential metabolites [PDF]
Arch ToxicolCylindrospermopsin (CYN) is a secondary metabolite produced by cyanobacteria. In view of its toxic effects, CYN is frequently classified as a cytotoxin, although it has been associated with neurotoxicological effects.
C. Plata-Calzado +3 more
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Journal of the American Chemical Society, 2022
Cylindrospermopsin, a major cyanotoxin, is produced by freshwater cyanobacteria. Its biosynthesis starts from arginine and glycine and involves five polyketide synthases and several tailoring enzymes. We report the identification of 7-deoxy-desulfo-argino-cylindrospermopsin in several cylindrospermopsin-producing cyanobacteria using mass spectrometry ...
Méjean, Annick +2 more
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Cylindrospermopsin, a major cyanotoxin, is produced by freshwater cyanobacteria. Its biosynthesis starts from arginine and glycine and involves five polyketide synthases and several tailoring enzymes. We report the identification of 7-deoxy-desulfo-argino-cylindrospermopsin in several cylindrospermopsin-producing cyanobacteria using mass spectrometry ...
Méjean, Annick +2 more
openaire +2 more sources
Biosynthesis of Cylindrospermopsin
The Journal of Organic Chemistry, 1999Studies on the biosynthesis of cylindrospermopsin (1), a potent hepatotoxin associated with the cyanobacterium Cylindrospermopsis raciborskii, indicate that 1 is an acetogenin with guanidinoacetic acid serving as the starter unit of the polyketide chain. Feeding experiments show that C14 and C15 of 1 are derived from C1 and C2 of glycine, respectively,
D L, Burgoyne +3 more
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Harmful Algae, 2011
Abstract A filamentous cyanobacterium isolated from the plankton of a eutrophic reservoir in Queensland (Australia) was, based on morphological features, putatively identified as Raphidiopsis mediterranea Skuja. Strain FSS1-150/1 was screened by HPLC MS/MS for a number of common cyanotoxins and was shown to produce both cylindrospermopsin (CYN) and ...
Glenn B. McGregor +3 more
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Abstract A filamentous cyanobacterium isolated from the plankton of a eutrophic reservoir in Queensland (Australia) was, based on morphological features, putatively identified as Raphidiopsis mediterranea Skuja. Strain FSS1-150/1 was screened by HPLC MS/MS for a number of common cyanotoxins and was shown to produce both cylindrospermopsin (CYN) and ...
Glenn B. McGregor +3 more
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Cylindrospermopsin impairs zebrafish (Danio rerio) embryo development
Marine Environmental Research, 2022Cyanotoxins are among common contaminants that can impair human, animal, and environmental health. Cylindrospermopsin (CYN) is an abundant form of cyanotoxins elevated following algal bloom in the water worldwide. Previous studies have described CYN effects on several organs in mammals.
A.C.N. Moraes +3 more
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Characterization of cylindrospermopsin chlorination
Science of The Total Environment, 2010In temperate countries, the occurrence of cyanobacterial blooms threatens drinking water resources. Consequently, cyanotoxins are increasingly considered in water treatment, and their reactions with chlorine used to disinfect drinking water are particularly investigated.
Merel, Sylvain +4 more
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Total Synthesis of (±)-Cylindrospermopsin
Journal of the American Chemical Society, 2000The first total synthesis of the novel hepatotoxin (±)-cylindrospermopson (1) has been accomplished in 20 steps from 4-methoxy-3-methylpyridine (12) in 3.5% overall yield. The substituted piperidine A ring 19 was generated stereospecifically by a four-step sequence using the addition of trimethylsilylethynylmagnesium bromide to 12 to give 16 and ...
Chaoyu Xie +2 more
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