Results 211 to 220 of about 5,682 (266)

Identification of 7-Deoxy-desulfo-argino-cylindrospermopsin, the Missing Piece in Cylindrospermopsin Biosynthesis

Journal of the American Chemical Society, 2022
Cylindrospermopsin, a major cyanotoxin, is produced by freshwater cyanobacteria. Its biosynthesis starts from arginine and glycine and involves five polyketide synthases and several tailoring enzymes. We report the identification of 7-deoxy-desulfo-argino-cylindrospermopsin in several cylindrospermopsin-producing cyanobacteria using mass spectrometry ...
Méjean, Annick, Lequin, Olivier, Ploux, Olivier   +2 more
openaire   +2 more sources

Cylindrospermopsin exposure promotes redox unbalance and tissue damage in the liver of Poecilia reticulata, a neotropical fish species

Journal of Toxicology and Environmental Health, Part A, 2023
There is a growing concern regarding the adverse risks exposure to cylindrospermopsin (CYN) might exert on animals and humans. However, data regarding the toxicity of this cyanotoxin to neotropical fish species are scarce. Using the fish species Poecilia
Simone Maria Teixeira de Sabóia-Morais, João Marcos de Lima Faria, Jéssica Custódio da Silva Rabelo, A. L. Hanusch, L. A. Mesquita, Raquel de Andrade Silva, J. M. de Oliveira, L. W. O. de Jesus   +7 more
semanticscholar   +1 more source

Biosynthesis of Cylindrospermopsin

The Journal of Organic Chemistry, 1999
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Thomas Hemscheidt, Maria T. C. Runnegar, Richard E. Moore, David L. Burgoyne   +3 more
openaire   +4 more sources

ChemInform Abstract: The Cylindrospermopsin Alkaloids

ChemInform, 2011
AbstractReview: 209 refs.
Daniel M. Evans, Patrick J. Murphy
openaire   +4 more sources

Characterization of cylindrospermopsin chlorination

Science of The Total Environment, 2010
In temperate countries, the occurrence of cyanobacterial blooms threatens drinking water resources. Consequently, cyanotoxins are increasingly considered in water treatment, and their reactions with chlorine used to disinfect drinking water are particularly investigated.
Merel, Sylvain, Clément, Michel, Mourot, Annick, Fessard, Valérie, Thomas, Olivier   +4 more
openaire   +3 more sources

Total Synthesis of (±)-Cylindrospermopsin

Journal of the American Chemical Society, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Maria T. Runnegar, Barry B. Snider, Chaoyu Xie   +2 more
openaire   +3 more sources

Syntheses of the cylindrospermopsin alkaloids

Tetrahedron, 2006
Abstract An intramolecular 1,3-dipolar cycloaddition has efficiently constructed the A-ring portions of the cylindrospermopsin alkaloids. A nitro-aldol addition of an elaborated nitroalkane to a pyrimidine aldehyde followed by an intramolecular reductive guanidinylation has enabled the syntheses of all three alkaloids in this family in 18–19 steps ...
Ryan E. Looper, Robert M. Williams, Maria T. Runnegar   +2 more
openaire   +2 more sources

First occurrence of cylindrospermopsin in freshwater in France

Environmental Toxicology, 2008
AbstractEleven waterbodies in Western France dominated by cyanobacteria of the genera Aphanizomenon and Anabaena were analyzed in September 2006 for microcystins (MC) and cylindrospermopsin (CYN). CYN was detected for the first time in France in four of them in the presence of Aphanizomenon flos‐aquae and in the presence of Anabaena planctonica in the ...
Brient, Luc, Lengronne, Marion, Bormans, Myriam, Fastner, Jutta   +3 more
openaire   +5 more sources

ChemInform Abstract: A Biomimetic Approach to the Cylindrospermopsin Alkaloids.

ChemInform, 2011
AbstractA tethered Biginelli condensation of hemiaminal derived from compound (I) with β‐keto ester (II) provides access to the tricyclic guanidine moiety found in cylindrospermin alkaloids.
Daniel M. Evans, Patrick J. Murphy
openaire   +4 more sources

Cytotoxicity Screening for the Cyanobacterial Toxin Cylindrospermopsin

Journal of Toxicology and Environmental Health, Part A, 2009
The cell lines C3A, HepG2, NCI-87, HCT-8, HuTu-80, Caco-2, and Vero were screened for sensitivity to the cyanobacterial toxin cylindrospermopsin (CYN), with the aim of determining the most sensitive cells to be used in cytotoxicity tests. Cell lines were chosen to be representative of the organs targeted by the toxin; liver, kidney, intestine, and were
Froscio, S., Fanok, S., Humpage, A.
openaire   +4 more sources