Results 111 to 120 of about 313 (137)
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Total Synthesis of (±)-Cylindrospermopsin
Journal of the American Chemical Society, 2000The first total synthesis of the novel hepatotoxin (±)-cylindrospermopson (1) has been accomplished in 20 steps from 4-methoxy-3-methylpyridine (12) in 3.5% overall yield. The substituted piperidine A ring 19 was generated stereospecifically by a four-step sequence using the addition of trimethylsilylethynylmagnesium bromide to 12 to give 16 and ...
Chaoyu Xie +2 more
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Interlaboratory comparison trial on cylindrospermopsin measurement
Analytical Biochemistry, 2004The hepatotoxin cylindrospermopsin (CYN) is a potent inhibitor of protein synthesis in mammalian cells. It is produced by freshwater cyanobacterial blooms in countries such as Australia, the United States, Israel, Thailand, and Brazil. An interlaboratory comparison was organized as a first step to evaluate the measurement of CYN in lyophilized ...
Andrea, Törökné +15 more
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The Cylindrospermopsin Alkaloids
2011Abstract The cylindrospermopsin alkaloids are a family of structurally similar toxic natural products first encountered with the isolation of cylindrospermopsin from the cyanobacterium Cylindrospermopsis raciborskii , which was the causative agent in the poisoning of 148 inhabitants of Palm Island, Australia.
Daniel M, Evans, Patrick J, Murphy
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Syntheses of the cylindrospermopsin alkaloids
Tetrahedron, 2006Abstract An intramolecular 1,3-dipolar cycloaddition has efficiently constructed the A-ring portions of the cylindrospermopsin alkaloids. A nitro-aldol addition of an elaborated nitroalkane to a pyrimidine aldehyde followed by an intramolecular reductive guanidinylation has enabled the syntheses of all three alkaloids in this family in 18–19 steps ...
Ryan E. Looper +2 more
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Genotoxicity investigation of a cyanobacterial toxin, cylindrospermopsin
Toxicon, 2002Cylindrospermopsin (CYN), a potent cyanobacterial hepatotoxin produced by Cylindrospermopsis raciborskii and other cyanobacteria, is regularly found in water supplies in many parts of the world, and has been associated with the intoxication of humans and livestock.
Shen, X. Y. +3 more
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Total Synthesis of rac‐Cylindrospermopsin
ChemInform, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
Barry B. Snider, Chaoyu Xie
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Cytotoxicity Screening for the Cyanobacterial Toxin Cylindrospermopsin
Journal of Toxicology and Environmental Health, Part A, 2009The cell lines C3A, HepG2, NCI-87, HCT-8, HuTu-80, Caco-2, and Vero were screened for sensitivity to the cyanobacterial toxin cylindrospermopsin (CYN), with the aim of determining the most sensitive cells to be used in cytotoxicity tests. Cell lines were chosen to be representative of the organs targeted by the toxin; liver, kidney, intestine, and were
Froscio, S., Fanok, S., Humpage, A.
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ChemInform Abstract: The Cylindrospermopsin Alkaloids
ChemInform, 2012AbstractReview: 209 refs.
Daniel M. Evans, Patrick J. Murphy
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A biomimetic approach to the cylindrospermopsin alkaloids
Chemical Communications, 2011The tethered Biginelli condensation between hemiaminal 21 and β-keto ester 22 is reported, leading to a model tricyclic core of the cylindrospermopsin alkaloids.
Daniel M, Evans, Patrick J, Murphy
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Cylindrospermopsin effects on protein profile of HepG2 cells
Toxicology Mechanisms and Methods, 2016Human hepatoma cells (HepG2) were exposed to purified cylindrospermopsin (CYN), a potent toxicant for eukaryotic cells produced by several cyanobacteria. Exposure to 10 μg l-1 of CYN for 24 h resulted in alteration of expression of 48 proteins, from which 26 were identified through mass spectrometry.
Samuel, Liebel +5 more
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