Results 171 to 180 of about 36,503 (286)

Importance of genetic polymorphism of S-mephenytoin-4′-hydroxylase(CYP2C19) in eradication of Helicobacter pylori

, 2000
Tatsusige Nisijima, Yoriaki Endo, Shinichi Ota, Kenji Fujiwara   +3 more
openalex   +1 more source

CYP2C19 pharmacogenetics in the clinical use of proton‐pump inhibitors for gastro‐oesophageal reflux disease: variant alleles predict gastric acid suppression, but not oesophageal acid exposure or reflux symptoms [PDF]

, 2003
Lorraine Egan, Gennett M. Myhre, D. C. Mays, Ross Dierkhising, Patricia P. Kammer, Joseph A. Murray   +5 more
openalex   +1 more source

Recommendations for (Pharmaco)Genetic Sampling in Patients Following Allogeneic Hematopoietic Stem Cell Transplantation

Clinical and Translational Science, Volume 18, Issue 8, August 2025.
ABSTRACT In patients receiving allogenic hematopoietic stem cell transplantation (aHSCT) complete chimerism is desired. However, this brings a challenge when non‐invasive assessment of recipient germline DNA is required for genetic testing. Here, we aim to create awareness for (pharmaco)genetic sampling in patients following aHSCT based on a case ...
Anniek Bokma, Maja Matic, Arwin Ralf, Bianca J. C. van den Bosch, Manfred Kayser, Ron H. N. van Schaik, Melvin Lafeber, Marieke J. H. Coenen, Florence Atrafi   +8 more
wiley   +1 more source

The effect of antineoplastic agent vinblastine and vincristine on the CYP3A4, CYP2C19 and CYP2D6 activity in human liver microsomes

, 2000
Hua Li, Norimitsu Kurata, Yuki Nishimura, Mariko Iwase, Eiji Uchida, Hajime Yasuhara   +5 more
openalex   +1 more source

Pharmacokinetics of Bocidelpar, ASP0367, in Renal and Hepatic Impairment: Results From Two Phase 1 Studies

Clinical and Translational Science, Volume 18, Issue 8, August 2025.
ABSTRACT Bocidelpar is a peroxisome proliferator‐activated receptor δ modulator designed to address mitochondrial impairment. Two open‐label, single‐dose phase 1 studies (NCT05117294/NCT04942964) investigated the effect of severe renal or mild/moderate hepatic impairment on bocidelpar pharmacokinetics and safety.
Megumi Iwai, Nakyo Heo, Kentaro Hashimoto, Sayuri Guro, Selina Moy, Anna Spence, Tomasz Wojtkowski, Lauren Benner, Melanie Helmick, Tong Zhu, Brian C. Ferslew   +10 more
wiley   +1 more source

Different inhibitory effect of fluvoxamine on omeprazole metabolism between CYP2C19 genotypes [PDF]

, 2004
Norio Yasui‐Furukori, Takenori Takahata, Taku Nakagami, Gen Yoshiya, Yoshimasa Inoue, Sunao Kaneko, Tomonori Tateishi   +6 more
openalex   +1 more source

Safety and effectiveness of stiripentol in patients with Dravet syndrome: A prospective, 3‐year, postmarketing surveillance study

Developmental Medicine &Child Neurology, Volume 67, Issue 8, Page 1034-1041, August 2025.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16285 Abstract Aim To conduct a postmarketing surveillance study of patients with Dravet syndrome in Japan to investigate the safety and effectiveness of long‐term, real‐world, clinical use of stiripentol (STP).
Yuki Kitamura, Hiroaki Ohyabu, Tatsuo Miura, Naomi Takei‐Masuda, Daisuke Matsui, Yushi Inoue, Yoko Ohtsuka   +6 more
wiley   +1 more source

Enantioselective Analysis of Citalopram and its Metabolites in Postmortem Blood and Genotyping For CYD2D6 and CYP2C19 [PDF]

, 2004
Peter Aaby, Björn Carlsson, A.-L. Zackrisson, Bertil Lindblom, Marja­‐Liisa Dahl, M.G. Scordo, Henrik Druid, Johan Ahlner   +7 more
openalex   +1 more source

Drug Exposure in Chronic Kidney Disease: It Is Not Just About the Glomerular Filtration Rate

Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.
ABSTRACT Chronic kidney disease (CKD) affects over 10% of the world's population and is associated with high morbidity and mortality rates. The management of CKD is complex; CKD alters drug pharmacokinetics and pharmacodynamics and further complicates therapeutic strategies regimens.
Sophie Liabeuf, Jessica Berdougo‐Tritz, Lucie Augey, Aïcha Mbarek, Michel Jadoul, Gilbert Deray, Ziad A. Massy   +6 more
wiley   +1 more source

Omeprazole Treatment of Korean Patients: Effects on Gastric pH and Gastrin Release in Relation to CYP2C19 Geno‐ and Phenotypes [PDF]

, 2004
Hyung‐Keun Roh, P.S. Kim, Don‐Haeng Lee, Gunnel Tybring, Mohamed Sagar, Chang‐Shin Park, Rein Seensalu, Leif Bertilsson   +7 more
openalex   +1 more source