Results 181 to 190 of about 21,299 (206)

Clopidogrel, CYP2C19, and a Black Box

The Journal of Clinical Pharmacology, 2013
AbstractIt has been presumed that CYP2C19 has a major role in the metabolism of clopidogrel. This presumption has been based on in vitro drug metabolism studies using microsomes from baculovirus infected insect cells (BD‐Supersomes™). If clopidogrel were primarily a CYP2C19 substrate, a drug/drug interaction with CYP2C19 inhibitors, such as proton pump
Neville F, Ford, Dirk, Taubert
openaire   +2 more sources

The CYP2C19 Enzyme Polymorphism

Pharmacology, 2000
The genetic test is gradually replacing probe drugs as the primary tool for screening populations for the CYP2C19 polymorphism. A full appreciation for the clinical and toxicological relevance of this genetic variation is presently limited. Further research is needed in several areas.
openaire   +2 more sources

Effect of glycyrrhizin on CYP2C19 and CYP3A4 activity in healthy volunteers with different CYP2C19 genotypes

Xenobiotica, 2010
The objective of this study was to investigate the interaction between glycyrrhizin and omeprazole and observe the effects of glycyrrhizin on CYP2C19 and CYP3A4 activities in healthy Chinese male volunteers with different CYP2C19 genotypes. Eighteen healthy subjects (six CYP2C19*1/*1, five CYP2C19*1/*2, one CYP2C19*1/*3, five CYP2C19*2/*2 and one ...
J-H, Tu, D-L, Hu, L-L, Dai, Y, Sun, L, Fan, M, Zhang, Z-R, Tan, Y, Chen, Z, Li, H-H, Zhou   +9 more
openaire   +2 more sources

Influence of Azimilide on CYP2C19 Mediated Metabolism

Clinical Pharmacology & Therapeutics, 2003
Clinical Pharmacology & Therapeutics (2003) 73, P32–P32; doi:
Mohamed, El Mouelhi, Dan J, Worley, Barbara, Kuzmak, Anthony J, Destefano, Gary A, Thompson   +4 more
openaire   +2 more sources

Assessment of CYP2C19 genetic polymorphisms in a Korean population using a simultaneous multiplex pyrosequencing method to simultaneously detect the CYP2C19*2, CYP2C19*3, and CYP2C19*17 alleles.

Journal of clinical pharmacy and therapeutics, 2011
CYP2C19 is a drug-metabolizing enzyme showing various genetic polymorphisms that may cause marked interindividual and interethnic variability in the disposition of its substrates. We assessed CYP2C19 genetic polymorphisms in a Korean population using a newly developed multiplex pyrosequencing method.A multiplex pyrosequencing method to simultaneously ...
K-A, Kim, W-K, Song, K-R, Kim, J-Y, Park
openaire   +1 more source

CYP2C19 genetic mutations in North Indians

Clinical Pharmacology & Therapeutics, 2000
To identify defective alleles of CYP2C19 (CYP2C19*2 and *3) in North Indians.One hundred extensive metabolizers and 21 poor metabolizers of omeprazole were genotyped with respect to CYP2C19*2 and *3 alleles with polymerase chain reaction-based diagnostic tests.Fifty-two extensive metabolizers and six poor metabolizers were homozygous with the CYP2C19*1/
J K, Lamba, R K, Dhiman, K K, Kohli
openaire   +2 more sources

[Genotyping of CYP2D6 and CYP2C19].

Casopis lekaru ceskych, 2008
Polymorphisms in drug metabolizing enzymes are considered as a major factor influencing the incidence of adverse drug reactions or failure of pharmacotherapy. Our aim was to compare the distribution of functional polymorphisms in the genes CYP2D6 and CYP2C19 between healthy control group and of patients reffered to our department due to adverse drug ...
O, Slanar, M, Drazd'áková, K, Babiárová, K, Pechandová, H, Buzková, F, Perlík, T, Zima   +6 more
openaire   +1 more source

CYP2C19 Testing

2022
openaire   +1 more source

CYP2C19*2 and CYP2C19*3 allelomorphism in Turkish population

International Journal of Cardiology, 2017
openaire   +3 more sources

Impact of CYP2C19 Genotype on Escitalopram Exposure and Therapeutic Failure: A Retrospective Study Based on 2,087 Patients

American Journal of Psychiatry, 2018
Espen Molden, Marin Jukic
exaly