Results 151 to 160 of about 27,792 (251)

Xanomeline and Trospium Chloride: Mechanism of Action, Clinical, and Translational Science

Clinical and Translational Science, Volume 19, Issue 9, September 2026.
ABSTRACT Xanomeline‐trospium chloride (Cobenfy, formerly KarXT) is a first‐in‐class, oral central M1/M4 muscarinic receptor agonist approved for the treatment of schizophrenia in adults. Cobenfy represents a paradigm shift by avoiding direct dopamine D2 receptor blockade and thus significantly reduces the burden of metabolic, extrapyramidal, and ...
Samantha Avila, Ingrid L. Chen
wiley   +1 more source

KOAH hastalarında CYP2C19*2 ve CYP2C19*3 polimorfizimlerinin klopidogrel direnci üzerine etkisi

, 2017
Kronik Obstrüktif Akciğer Hastalığı (KOAH), zararlı partikül ve gazların kronik inhalasyonu sonucu akciğerlerde oluşan anormal inflamatuar yanıtın neden olduğu, ilerleyici hava akımı obstrüksiyonu ile karakterize bir hastalıktır.
ZELİHA FUNDA KILIK
core  

Understanding Postmarketing Requirements and Commitments for CYP3A‐Mediated Drug–Drug Interactions: An Analysis of FDA‐Approved Drugs From 2015 to 2024

Clinical and Translational Science, Volume 19, Issue 9, September 2026.
ABSTRACT Addressing knowledge gaps at drug approval through drug–drug interaction (DDI)‐related postmarketing requirements (PMRs) and commitments (PMCs) is essential for safe and effective use. This analysis reviewed CYP3A‐related PMRs and PMCs, the most evaluated enzyme in postmarketing studies, to characterize their scope.
Jingjing Yu, Ichiko Petrie, Sophie Argon, Katie Owens, Isabelle Ragueneau‐Majlessi   +4 more
wiley   +1 more source

Gene‐Based Clustering Identifies QSOX1 and IL1RAP as Biomarkers of Metabolic Dysfunction‐Associated Steatotic Liver Disease

Liver International, Volume 46, Issue 9, September 2026.
ABSTRACT Background and Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a progressive liver disease that ranges from simple steatosis to inflammation, fibrosis and cirrhosis. To address the unmet need for new MASLD biomarkers, we aimed to identify candidate biomarkers using publicly available RNA sequencing (RNA‐seq) and ...
Wenfeng Ma, Jinrong Huang, Benqiang Cai, Mumin Shao, Xuewen Yu, Mikkel Breinholt Kjær, Minling Lv, Xin Zhong, Shaomin Xu, Bolin Zhan, Qun Li, Qi Huang, Mengqing Ma, Lei Cheng, Yonglun Luo, Henning Grønbæk, Xiaozhou Zhou, Lin Lin   +17 more
wiley   +1 more source

Topliss‐Guided Optimization of Acetanilide‐Based Soluble Epoxide Hydrolase Inhibitors: Exploring the Pentafluorosulfanyl Group as a Potency‐Enhancing Motif

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Can an amide analog retain the high potency of the classic urea motif in soluble epoxide hydrolase inhibitors? Through a single unconventional switch, the introduction of the underexplored pentafluorosulfanyl group into an amide analog of TPPU, the authors restored high inhibitory potency.
Alba López‐Ruiz, Eugènia Pujol, Cristian Ramos, Valeria Rizzo, Christophe Morisseau, Cristina Val, Tiziana Ginex, Javier Vázquez, Sandra Codony, Andreea L. Turcu, Belén Pérez, Elena Sáez, Antonio Pineda‐Lucena, Bruce D. Hammock, F. Javier Luque, M. Isabel Loza, José Brea, Santiago Vázquez   +17 more
wiley   +1 more source

Pyridyl‐Thiazole‐Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Anderson José Firmino Santos da Silva, Daiane Santiago da Cruz Olimpio, Lucas Manoel da Silva Sousa, Graziella Leite Brondani, Tacylla Lima Silva, Wéllyda Belmira de Lira Silva, Natáli Tereza Capistrano Costa, Marcelo Zaldini Hernandes, Policarpo Ademar Sales Junior, Valéria Rêgo Alves Pereira, Ana Cristina Lima Leite   +10 more
wiley   +1 more source

Comparison of CYP2C9, CYP2C19, CYP2D6, ABCB1, and SLCO1B1 gene-polymorphism frequency in Russian and Nanai populations

, 2017
Dmitrij Alekseevitch Sychev,1 Grigorij Nikolaevich Shuev,1 Salavat Shejhovich Suleymanov,2 Kristina Anatol’evna Ryzhikova,3 Karin Badavievich Mirzaev,3 Elena Anatol’evna Grishina,3 Natalia Evgenievna Snalina,3 Zhannet Alimovna Sozaeva,3 Anton
Shuev GN, Suleymanov SS, Snalina NE, Ryzhikova KA, Sychev DA, Sozaeva ZA, Grishina EA, Grabuzdov AM, Matsneva IA, Mirzaev KB   +9 more
core  

Case Report: Complex venlafaxine overdose and prolonged intensive care unit hospitalization associated to combined CYP2D6 and CYP2C19 polymorphisms. [PDF]

Front Psychiatry
Michel B, Boland L, Gérard L, Montiel V, Haufroid V, Pinto Pereira J.   +5 more
europepmc   +1 more source

CYP2C19 in ACS Patients

Journal of the American College of Cardiology, 2016
Sibbing, Dirk, Gross, Lisa, Massberg, Steffen   +2 more
openaire   +1 more source

Repositioning candidate gene approaches in the post-GWAS era: a clinical perspective from psychiatric pharmacogenetics. [PDF]

Front Genet
Pjevac M, Bon J, Dolžan V.
europepmc   +1 more source