Results 181 to 190 of about 40,704 (273)

Plant‐Based Mycetoma Inhibitors Targeting the 50S Ribosomal Protein of Nocardia brasiliensis: In Silico Approach

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
In‐silico drug discovery pipeline for Mycetoma caused by Nocardia brasiliensis. A library of 1034 phytocompounds was screened to identify potent inhibitors, with Parviflorone F showing strong binding and stability against the 50S ribosomal unit. Molecular dynamics confirmed its inhibitory potential, offering a promising therapeutic candidate.
Sandra Jose, Manjunathan Jagadeesan, Meenambiga Setti Sudharsan, Pasiyappazham Ramasamy, Shyamala Gowri, Muthu Thiruvengadam, Sowmya Hari, Baskar Venkidasamy   +7 more
wiley   +1 more source

Therapeutic drug monitoring, liquid biopsies or pharmacogenomics for prediction of human drug metabolism and response

British Journal of Clinical Pharmacology, Volume 91, Issue 6, Page 1569-1579, June 2025.
Pharmacokinetics plays a central role in understanding the significant interindividual differences that exist in drug metabolism and response. Effectively addressing these differences requires a multi‐faceted approach that encompasses a variety of tools and methods.
Magnus Ingelman‐Sundberg, Espen Molden
wiley   +1 more source

CYP2C19*17 Polymorphisms And Platelet Aggregation In Coronary Artery Disease Patients With Clopidgrel [PDF]

, 2017
Background: Clopidogrel is the alternative therapy for patients with Coronary Artery Disease (CAD) that couldn’t use Aspirin as antiplatelet. There’s some factors that contribute to clopidogrel effectiveness, such as obesity, Diabetes Mellitus, Smoking,
Ananda, Yuki, Queljoe, Doddy de, Rochmawati, Ike Dhiah   +2 more
core  

Comprehensive Characterization of Antidepressant Pharmacogenetics: A Systematic Review of Studies in Major Depressive Disorder

Clinical and Translational Science, Volume 18, Issue 6, June 2025.
ABSTRACT Pharmacogenetics is a promising strategy to facilitate individualized care for patients with Major Depressive Disorder (MDD). Research is ongoing to identify the optimal genetic markers for predicting outcomes to antidepressant therapies. The primary aim of this systematic review was to summarize antidepressant pharmacogenetic studies to ...
Caroline W. Grant, Karina Delaney, Linsey E. Jackson, Justin Bobo, Leslie C. Hassett, Liewei Wang, Richard M. Weinshilboum, Paul E. Croarkin, Melanie T. Gentry, Ann M. Moyer, Arjun P. Athreya   +10 more
wiley   +1 more source

From genes to drugs: CYP2C19 and pharmacogenetics in clinical practice

Frontiers in Pharmacology
The CYP2C19 gene is frequently included in different pharmacogenomic panels tested in clinical practice, due to its involvement in the metabolism of a myriad of frequently prescribed medications.
Qamar Shubbar, Qamar Shubbar, Aminah Alchakee, Aminah Alchakee, Khaled Walid Issa, Abdul Jabbar Adi, Ali Ibrahim Shorbagi, Maha Saber-Ayad, Maha Saber-Ayad   +8 more
doaj   +1 more source

A study of associations of polymorphic variants of cytochrome P-450 system genes and multi-drug resistance gene with the development of druginduced hyperprolactinemia in patients with schizophrenia [PDF]

, 2017
The detection of clinical and biological associations in different alleles and genotypes allows to create the fundament for development methods, which help to identify risk of side-effects in patients with schizophrenia, who received long-term ...
Воронина, Е. Н., Пожидаев, И. В.   +1 more
core  

Comparative in vitro assessment of CYP2C19 inhibition by ilaprazole and conventional proton pump inhibitors using a high throughput fluorometric assay. [PDF]

Sci Rep
Priyadharshini A, Vijayakumar TM, Damodharan N, Vasanth KM, Elaiyaraja A.   +4 more
europepmc   +1 more source

Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes. [PDF]

Hum Genomics
Johansson I, Lu Y, Zhou Y, Krebs K, Akcan M, Milani L, Ingelman-Sundberg M.   +6 more
europepmc   +1 more source

Genetic and clinical determinants of MACE and haemorrhage in antiplatelet therapy: insights from pharmacogenomic analysis. [PDF]

Front Cardiovasc Med
Wang Y, Yuan S, Li M, Feng W, Li J, Chen W, Berdi A, Kou Y, Yuan Y, Zhao J.   +9 more
europepmc   +1 more source

Physiologically based pharmacokinetic modeling supports investigation of potential drug-drug interactions in the pre- and early post-hematopoietic stem cell transplantation stages. [PDF]

Front Pharmacol
Wang P, Lu J, Yang J.
europepmc   +1 more source