Results 181 to 190 of about 45,621 (284)
Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 1, January 2026.ABSTRACT Psychotropic drug concentrations increase/decrease with hydrophilicity/lipophilicity after a low‐calorie pre‐bariatric surgery diet. To investigate underlying mechanisms, body weight and serum creatinine/cystatin C changes over the diet period were characterized and suggested to reflect changes in glomerular filtration and metabolic capacity ...
Magnus A. B. Axelsson +1 more
wiley +1 more source
UK Biobank: Transforming drug discovery and precision medicine
British Journal of Pharmacology, Volume 183, Issue 2, Page 234-248, January 2026.UK Biobank is a large‐scale, prospective study with extensive genetic and phenotypic data on half a million individuals. Volunteers, aged between 40 and 69 years, were recruited between 2006 and 2010 from the general population of the United Kingdom.
Jelena Bešević +11 more
wiley +1 more source
Clinical and Translational Science, Volume 19, Issue 1, January 2026.ABSTRACT Pharmacogenomics (PGx) is a rapidly evolving field that aims to personalize medicine by identifying genetic variations that influence drug response. While next‐generation sequencing (NGS)–based applications are not yet widely adopted in clinical routine, this study aimed to validate 9 genes of the NGS‐based Ion AmpliSeq Pharmacogenomics Panel ...
Yaowaluck Hongkaew +7 more
wiley +1 more source
Pharmacovigilance‐Based Identification and Mechanistic Exploration of Periodontitis‐Related Drugs
Journal of Clinical Periodontology, Volume 53, Issue 1, Page 117-126, January 2026.ABSTRACT Background Periodontitis is a common chronic inflammatory disease. However, drug‐related risks and underlying molecular mechanisms remain underexplored from large real‐world data. Methods We first mined the US Food and Drug Administration Adverse Event Reporting System (FAERS) database to identify drugs disproportionately associated with ...
Wuda Huoshen +11 more
wiley +1 more source
Cardiovascular Therapeutics, Volume 2026, Issue 1, 2026.Aims To evaluate the real‐world efficacy and safety of low‐dose (2.5 mg) mavacamten initiation in Chinese patients with symptomatic obstructive hypertrophic cardiomyopathy (oHCM). Methods and Results This single‐center observational study (Zhongshan Hospital, China; Oct 2024–Apr 2025) enrolled 72 symptomatic oHCM patients (NYHA II/III, LVEF ≥ 55 ...
Wenlong Yang +9 more
wiley +1 more source
Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.Chronic hyperglycemia is one of the main causes of diabetes mellitus, a common metabolic disorder. α‐Amylase inhibition, a key enzyme in carbohydrate digestion, is an appealing strategy for the regulation of postprandial blood glucose levels. The current research explored the α‐amylase inhibitory activity of Pithecellobium dulce (Roxb.) leaf extracts ...
Nur Mohammad Rasel +6 more
wiley +1 more source