Results 11 to 20 of about 36,503 (286)
Genetic Polymorphism of Cytochrome p450 (2C19) Enzyme in Iranian Turkman Ethnic Group [PDF]
Oman Medical Journal, 2013 Objective: Different findings indicate that CYP2C plays a clinical role in determining interindividual and interethnic differences in drug effectiveness. The ethnic differences in the frequency of CYP2C19 mutant alleles continue to be a significant study
Robabeh Ghiyas Tabari +4 more
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The impact of CYP2C19 genotype on phenoconversion by concomitant medication
Frontiers in Pharmacology, 2023 Introduction: Pharmacogenetics-informed drug prescribing is increasingly applied in clinical practice. Typically, drug metabolizing phenotypes are determined based on genetic test results, whereupon dosage or drugs are adjusted. Drug-drug-interactions (DDIs) caused by concomitant medication can however cause mismatches between predicted and observed ...
Laura M. de Jong +11 more
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The Pharmacogenetics of Cytochrome P450 2C19 Enzymes - Effects on Clopidogrel and Proton Pump Inhibitors [PDF]
Indonesian Biomedical Journal, 2014 BACKGROUND: Cytochrome P450 (CYP) enzymes play important roles in human, including drug metabolism. CYP2 is the largest family of human CYP, with its sequence comprising almost one third of all CYP sequences, and responsible for the metabolism of ...
Yusmiati Yusmiati, Dewi Muliaty
doaj +6 more sources
Clinical and Translational ScienceAbstractVoriconazole is the cornerstone of the treatment and prevention of fungal infections. While there is a good correlation between CYP2C19 genotype and voriconazole exposure during prophylactic treatment, no correlation was found in patients with invasive aspergillosis. Proinflammatory cytokines result in inhibition of CYP2C19 enzyme activity (and
Sylvia D. Klomp +6 more
openaire +5 more sources
Development of a Semi-Quantitative Assay to Detect Full-Length CYP2C19 RNA [PDF]
BioTechniques, 2000 Cytochrome P450 2C19 (CYP2C19) is the enzyme responsible for the metabolism of a number of drugs, including anticonvulsants and antidepressants. We have developed a semi-quantitative competitive RTPCR assay to estimate the degree of expression of the ...
Xiaoyan Wang +2 more
openalex +3 more sources
Effect of CYP2C19 genotypes on tamoxifen metabolism and early-breast cancer relapse
Scientific Reports, 2021 CYP2C19*2 and CYP2C19*17 might influence tamoxifen metabolism and clinical outcome. Our aim was to investigate the effect of CYP2C19 genotypes on tamoxifen concentrations and metabolic ratios (MRs) and breast cancer recurrence in a large cohort of ...
A. B. Sanchez-Spitman +5 more
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Inactive alleles of cytochrome P450 2C19 may be positively selected in human evolution Genome evolution and evolutionary systems biology [PDF]
, 2014 © 2014 Janha et al.; licensee BioMed Central Ltd.Background: Cytochrome P450 CYP2C19 metabolizes a wide range of pharmacologically active substances and a relatively small number of naturally occurring environmental toxins.
Janha, RE +5 more
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CYP2C19 Genetic Polymorphism in the East of Iran: Its Association with the Severity and Pattern of Coronary Artery Disease [PDF]
Journal of Cardio-Thoracic Medicine, 2019 Introduction: Since there has been a dearth of research on the assessment of CYP2C19 polymorphism in the east of Iran (Khorasan provinces), this study aimed to detect, CYP2C19*2 and CYP2C19*3 allele frequencies among patients with coronary artery disease.
Mahdi Zahedi +3 more
doaj +1 more source
Distribution of a novel CYP2C haplotype in Native American populations
Frontiers in Genetics, 2023 The CYP2C19 gene, located in the CYP2C cluster, encodes the major drug metabolism enzyme CYP2C19. This gene is highly polymorphic and no-function (CYP2C19*2 and CYP2C19*3), reduced function (CYP2C19*9) and increased function (CYP2C19*17) star alleles ...
Vanessa Câmara Fernandes +4 more
doaj +1 more source
Pharmacogenomic testing and its future in community pharmacy [PDF]
, 2020 Although it is common to see pharmacogenomic testing used North America and Australia, it is not yet part of practice in the UK. With the promise of genomic screening becoming part of the NHS, pharmacists must equip themselves with a knowledge of how the
Wright, David, Youssef, Essra
core +1 more source