Results 271 to 280 of about 45,621 (284)

CYP2C19 genetics in fatal carisoprodol intoxications

European Journal of Clinical Pharmacology, 2012
Carisoprodol, a frequently used muscle relaxant, can cause potentially fatal intoxications. Conversion to its active metabolite meprobamate is almost solely mediated by cytochrome P450 2C19 (CYP2C19), and mutations in this enzyme could have significant effects on serum concentrations.
Gudrun, Høiseth, Umair, Majid, Jørg, Mørland, Jørgen G, Bramness, Espen, Molden   +4 more
openaire   +2 more sources

Influence of Azimilide on CYP2C19 Mediated Metabolism

Clinical Pharmacology & Therapeutics, 2003
Clinical Pharmacology & Therapeutics (2003) 73, P32–P32; doi:
Mohamed, El Mouelhi, Dan J, Worley, Barbara, Kuzmak, Anthony J, Destefano, Gary A, Thompson   +4 more
openaire   +2 more sources

Effect of glycyrrhizin on CYP2C19 and CYP3A4 activity in healthy volunteers with different CYP2C19 genotypes

Xenobiotica, 2010
The objective of this study was to investigate the interaction between glycyrrhizin and omeprazole and observe the effects of glycyrrhizin on CYP2C19 and CYP3A4 activities in healthy Chinese male volunteers with different CYP2C19 genotypes. Eighteen healthy subjects (six CYP2C19*1/*1, five CYP2C19*1/*2, one CYP2C19*1/*3, five CYP2C19*2/*2 and one ...
J-H, Tu, D-L, Hu, L-L, Dai, Y, Sun, L, Fan, M, Zhang, Z-R, Tan, Y, Chen, Z, Li, H-H, Zhou   +9 more
openaire   +2 more sources

Assessment of CYP2C19 genetic polymorphisms in a Korean population using a simultaneous multiplex pyrosequencing method to simultaneously detect the CYP2C19*2, CYP2C19*3, and CYP2C19*17 alleles.

Journal of clinical pharmacy and therapeutics, 2011
CYP2C19 is a drug-metabolizing enzyme showing various genetic polymorphisms that may cause marked interindividual and interethnic variability in the disposition of its substrates. We assessed CYP2C19 genetic polymorphisms in a Korean population using a newly developed multiplex pyrosequencing method.A multiplex pyrosequencing method to simultaneously ...
K-A, Kim, W-K, Song, K-R, Kim, J-Y, Park
openaire   +1 more source

CYP2C19: The Support Crew II

2015
This chapter discusses the genetics, metabolic actions, substrates, inducers, and inhibitors of cytochrome P450 2C9.
Barbara Jericho, Alfredo Aguiar, Randal O. Dull   +2 more
openaire   +1 more source

CYP2C19 Testing

2022
openaire   +1 more source

CYP2C19*2 and CYP2C19*3 allelomorphism in Turkish population

International Journal of Cardiology, 2017
openaire   +3 more sources

Assessment of CYP2C19 genetic polymorphisms in a korean population using a simultaneous multiplex pyrosequencing method to simultaneously detect the CYP2C19*2, CYP2C19*3, and CYP2C19*17 alleles

Journal of Clinical Pharmacy and Therapeutics, 2010
K.-A. Kim, W.-K. Song, K.-R. Kim, J.-Y. Park   +3 more
openaire   +1 more source

Global distribution of CYP2C19 risk phenotypes affecting safety and effectiveness of medications

The Pharmacogenomics Journal, 2020
M. Biswas
semanticscholar   +1 more source

Impact of CYP1A2, CYP2C19, and CYP2D6 genotype- and phenoconversion-predicted enzyme activity on clozapine exposure and symptom severity

The Pharmacogenomics Journal, 2019
Dorothea Lesche, Sam Mostafa, I. Everall, C. Pantelis, C. Bousman   +4 more
semanticscholar   +1 more source