Results 21 to 30 of about 20,284 (182)

Pharmacogenetics of CYP2C19: functional and clinical implications of a new variant CYP2C19*17 [PDF]

British Journal of Clinical Pharmacology, 2010
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • CYP2C19 polymorphisms may have clinical consequences in relation to drugs extensively metabolized by the enzyme.• Recently a new variant CYP2C19*17 was discovered.• Unlike other commonly studied variant alleles, notably CYP2C19*2 and CYP2C19*3, which are defective, CYP2C19*17 is associated with enhanced ...
Li-Wan-Po, Alain, Girard, Thierry, Farndon, Peter, Cooley, Candy, Lithgow, James   +4 more
openaire   +3 more sources

The Prevalence of CYP2C19 Polymorphism in Patients with Symptomatic Intracranial Atherosclerosis

Cerebrovascular Diseases Extra
Introduction: Clopidogrel and aspirin were proved to have benefit in symptomatic intracranial stenosis. CYP2C19 polymorphism (CYP2C19*1, CYP2C19*2, CYP2C19*3, and CYP2C19*17 alleles) affects efficacy of clopidogrel.
Songchai Kittipanprayoon, Pongpat Vorasayan, Aurauma Chutinet, Pajaree Chariyavilaskul, Nijasri C. Suwanwela   +4 more
doaj   +1 more source

Development of a Semi-Quantitative Assay to Detect Full-Length CYP2C19 RNA

BioTechniques, 2000
Cytochrome P450 2C19 (CYP2C19) is the enzyme responsible for the metabolism of a number of drugs, including anticonvulsants and antidepressants. We have developed a semi-quantitative competitive RTPCR assay to estimate the degree of expression of the ...
Xiao-Yan Wang, René H. Levy, Rodney J.Y. Ho   +2 more
doaj   +1 more source

CYP2C19 genetic polymorphism in the Vietnamese population

Annals of Human Biology, 2019
Background: Genetic polymorphism of CYP2C19 has been shown to affect enzyme activity and thereby contribute to inter-individual variability in drug metabolism and response.
Nhung Phuong Vu, Hoa Thi Thanh Nguyen, Ngoc Thi Bich Tran, Ton Dang Nguyen, Hue Thi Thu Huynh, Xuan Thi Nguyen, Duong Thuy Nguyen, Hai Van Nong, Ha Hai Nguyen   +8 more
doaj   +1 more source

CYP2C19 and ABCB1 gene polymorphisms are differently distributed according to ethnicity in the Brazilian general population

BMC Medical Genetics, 2011
Background Recent studies have reported the clinical importance of CYP2C19 and ABCB1 polymorphisms in an individualized approach to clopidogrel treatment.
Mill José G, Nicolau José C, Coelho George LLM, Nascimento Raimundo M, Santos Diogo BG, Soares Renata AG, Santos Paulo CJL, Krieger José E, Pereira Alexandre C   +8 more
doaj   +1 more source

Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population

Clinical and Translational Science, 2022
Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic variants.
Line Skute Bråten, Magnus Ingelman‐Sundberg, Marin M. Jukic, Espen Molden, Marianne Kristiansen Kringen   +4 more
doaj   +1 more source

The Correlation of Two Different Real-Time PCR Devices for the Analysis of CYP2C19 Pharmacogenetic Results

Scientia Pharmaceutica, 2023
CYP2C19 is a highly polymorphic gene responsible for the metabolism of commonly used drugs. CYP2C19*1, the wild-type allele, is associated with normal enzyme activity, whereas CYP2C19*2 and CYP2C19*17 lead to null and increased enzyme activity ...
Alba Alonso Llorente, Josefa Salgado Garrido, Oscar Teijido Hermida, Fabricio González Andrade, Alberto Valiente Martín, Ana Fanlo Villacampa, Jorge Vicente Romero   +6 more
doaj   +1 more source

CYP2C19 loss-of-function is associated with increased risk of hypertension in a Hakka population: a case-control study

BMC Cardiovascular Disorders, 2023
Background Genetic factors have a certain proportion in the risk factors of hypertension. The purpose was to investigate the relationship of cytochrome P450 2C19 (CYP2C19) polymorphisms with hypertension in Hakka population.
Nan Cai, Cunren Li, Xianfang Gu, Wenfeng Zeng, Jiawei Zhong, Jingfeng Liu, Guopeng Zeng, Junxing Zhu, Haifeng Hong   +8 more
doaj   +1 more source

Up-Regulation of CYP2C19 Expression by BuChang NaoXinTong via PXR Activation in HepG2 Cells. [PDF]

PLoS ONE, 2016
Cytochrome P450 2C19 (CYP2C19) is an important drug-metabolizing enzyme (DME), which is responsible for the biotransformation of several kinds of drugs such as proton pump inhibitors, platelet aggregation inhibitors and antidepressants.
Hong Sun, Xiao-Ya Lou, Xiao-Ying Wu, Huan Wang, Qiang Qu, Shen-Lan Tan, Jun-Shan Ruan, Jian Qu, Hui Chen   +8 more
doaj   +1 more source

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source