Results 71 to 80 of about 40,704 (273)
Frequencies of Defective CYP2C19 Alleles in a Hong Kong Chinese Population: Detection of the Rare Allele CYP2C19*4 [PDF]
Clinical Chemistry, 1999 A genetic polymorphism in the metabolism of the anticonvulsant drug mephenytoin in humans is a prime example of interracial and individual variability in drug metabolism. This polymorphism affects the metabolism of several other clinically used drugs, some of which are of interest in psychopharmacotherapy (1).
Lam, KL +6 more
openaire +4 more sources
American Journal of Psychiatry, 2018 OBJECTIVE The antidepressant escitalopram is predominantly metabolized by the polymorphic CYP2C19 enzyme. The authors investigated the effect of CYP2C19 genotype on exposure and therapeutic failure of escitalopram in a large patient population.
M. Jukic +3 more
semanticscholar +1 more source
Clinical and Translational Science, 2020 Single nucleotide variants in the open reading frames (ORFs) of pharmacogenes are important causes of interindividual variability in drug response. The functional characterization of variants of unknown significance within ORFs remains a major challenge ...
Lingxin Zhang +9 more
semanticscholar +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Daily broad‐spectrum micronutrients are being used by the general public and formulations are receiving research interest in mental health settings. Despite concerns about combining medicines and broad‐spectrum micronutrients in mental health care, there have not been any formal evaluations of potential interactions.
Bess M. Kew +7 more
wiley +1 more source
CYP2C19 genetic polymorphism in the Vietnamese population
Annals of Human Biology, 2019 Background: Genetic polymorphism of CYP2C19 has been shown to affect enzyme activity and thereby contribute to inter-individual variability in drug metabolism and response.
Nhung Phuong Vu +8 more
doaj +1 more source
Polymorphisms of MDR1, CYP2C19 and P2Y12 genes in Indian population: Effects on clopidogrel response
Indian Heart Journal, 2013 Aims/objective: Influence of genetic variations on the response of clopidogrel, an antiplatelet drug is implicated. In the present study, the prevalence of single nucleotide polymorphisms of MDR1 (C3435T), CYP2C19 [CYP2C19*2 CYP2C19*3, CYP2C19*17] and ...
Kavita K. Shalia +4 more
doaj +1 more source
Frequencies of clinically important CYP2C19 and CYP2D6 alleles are graded across Europe
European Journal of Human Genetics, 2019 CYP2C19 and CYP2D6 are important drug-metabolizing enzymes that are involved in the metabolism of around 30% of all medications. Importantly, the corresponding genes are highly polymorphic and these genetic differences contribute to interindividual and ...
J. Petrović, V. Pešić, V. Lauschke
semanticscholar +1 more source
Clinical pharmacology and therapy, 2020 A risk mitigation strategy was implemented to determine if a higher prophylactic voriconazole dosage in patients with CYP2C19 rapid metabolizer neutropenic acute myeloid leukemia (AML) reduces the incidence of subtherapeutic trough concentrations ...
J. K. Hicks +16 more
semanticscholar +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia +4 more
wiley +1 more source
Архивъ внутренней медицины, 2022 Aims. To study the CYP2C19(681A/G) polymorphism among the population of the Trans-Baikal Territory in comparison with data in other regions of Russia and the world. Materials and methods. The study involved 132 people (81 women and 53 men).
A. A. Zhilina +4 more
doaj +1 more source