Results 81 to 90 of about 20,284 (182)

Ensemble Docking of FDA‐Approved and Peruvian Phytochemicals Against Monkeypox Virus Telomere‐Binding Protein

open access: yesChemistrySelect, Volume 11, Issue 9, 5 March 2026.
ABSTRACT Monkeypox is a reemerging zoonotic disease that has been spreading worldwide. Different approaches are being conducted to find effective treatments for this disease. To accelerate therapeutic discovery, we propose telomere‐binding protein (TBP) as a potential drug target because of its important role during virus maturation.
Edinson Gervacio‐Villarreal   +12 more
wiley   +1 more source

Association Between Levels of the Acute Phase Proteins Alpha‐1‐Acid Glycoprotein and C‐Reactive Protein and Serum Concentrations of Clozapine: A Study of 1106 Therapeutic Drug Monitoring Samples

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
ABSTRACT Several publications have reported elevated clozapine concentrations in patients experiencing infections or inflammatory reactions. Proposed mechanisms include increased levels of pro‐inflammatory cytokines that may inhibit clozapine metabolism and enhanced binding of clozapine to the acute phase protein alpha‐1‐acid glycoprotein (AGP).
Ketil Arne Espnes   +6 more
wiley   +1 more source

Managing High‐Risk Drug Interactions With Nirmatrelvir/Ritonavir: Experience From a Dedicated Pharmacology Advice Service

open access: yesClinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Nirmatrelvir boosted with ritonavir is a key antiviral against COVID‐19, yet ritonavir's potent CYP3A4 inhibition exposes patients to numerous drug–drug interactions. To make prescribing safer, a national proactive system providing expert pharmacology advice was implemented in France.
Youssef Libiad   +7 more
wiley   +1 more source

CYP2C19 *2/*2 Genotype is a Risk Factor for Multi-Site Arteriosclerosis: A Hospital-Based Cohort Study

open access: yesInternational Journal of General Medicine, 2023
Jieyao Xie, Tingjun Pan, Weiwen Luo, Songsheng Zhang, Yuquan Fang, Zhou Xu Intensive Care Unit, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of ChinaCorrespondence: Jieyao Xie, Intensive Care Unit, Meizhou ...
Xie J   +5 more
doaj  

CYP2C19*2 polymorphism and clopidogrel resistance [PDF]

open access: yesArchivos de cardiolog�a de M�xico (English ed. Internet), 2021
Beuy, Joob, Viroj, Wiwanitkit
openaire   +2 more sources

A Pharmacogenetics-Based Approach to Managing Gastroesophageal Reflux Disease: Current Perspectives and Future Steps

open access: yesPharmacogenomics and Personalized Medicine, 2023
Eda Eken,1,2 David S Estores,3 Emily J Cicali,1,2 Kristin K Wiisanen,1,2 Julie A Johnson1,2 1Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA; 2Center for Pharmacogenomics and ...
Eken E   +4 more
doaj  

Managing the Complex Intersection Between Substance Use Disorders and Infectious Diseases

open access: yes
JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 3, March 2026.
Karissa Chow   +4 more
wiley   +1 more source

Clinician Satisfaction With Pharmacogenomics Clinical Services at a Multistate Health System

open access: yesClinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Pharmacogenomics (PGx) utilizes genetic information to optimize medication management. Barriers to PGx implementation include limited confidence and knowledge in applying results, time constraints, and financial barriers. Clinical services across health systems vary greatly with differing consultative PGx service models.
Kristen Jacobsen   +4 more
wiley   +1 more source

Knowledge and Attitudes Regarding Pharmacogenetics of Pharmacists in the Netherlands: A National Online Survey Study

open access: yesJournal of Evaluation in Clinical Practice, Volume 32, Issue 2, March 2026.
ABSTRACT Rationale, Aims and Objectives Pharmacogenetics is considered a promising method to improve pharmacotherapy, yet its implementation in clinical practice is hampered, limiting its potential benefits to the public. Previously, its uptake has been investigated within a variety of healthcare professional groups.
Emma Y. De Brabander   +34 more
wiley   +1 more source

Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils

open access: yesPediatric Allergy and Immunology, Volume 37, Issue 3, March 2026.
Abstract Background Eosinophilic esophagitis (EoE) is a chronic allergic disorder driven by type 2 inflammation, characterized by eosinophilic infiltration and esophageal epithelial abnormalities, including barrier dysfunction, basal cell hyperplasia, epithelial thickening, and loss of differentiation.
Ravi Gautam   +6 more
wiley   +1 more source

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