Results 161 to 170 of about 49,005 (303)

CYP2D6 Gene [PDF]

, 2020
openaire   +1 more source

Influence of 5-HT_3bReceptor AAG Deletion Mutation and CYP2D6*10 on the Ondansetron Treatment [PDF]

, 2006
Ju‐Hee Kang, Helen Ki Shinn, Sung-Ho Shin, Chang Shin Park, Hong Sik Lee, Jang Ho Song, Young Deog, Hae Jin Park   +7 more
openalex   +1 more source

Evaluation of the Pharmacokinetics, Disposition, and Metabolism of Miricorilant, a Novel Glucocorticoid Receptor Modulator for the Treatment of Metabolic Dysfunction‐Associated Steatohepatitis in Nonclinical and Clinical Studies

The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Miricorilant is a novel selective glucocorticoid receptor (GR) modulator with mixed agonist/antagonist effects at the GR and modest antagonism at the mineralocorticoid receptor that is being developed for the treatment of metabolic dysfunction‐associated steatohepatitis.
Hazel J. Hunt, Kirsteen M. Donaldson, Jeevan R. Kunta, Joseph M. Custodio   +3 more
wiley   +1 more source

A Rational Approach to Pharmacotherapy in Pregnancy

The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Most pregnant individuals are exposed to at least one medication, whether prescription or over the counter, during pregnancy. Despite the ubiquity of medication use in pregnancy, there remains no standardized framework to guide clinicians in selecting the most appropriate pharmacotherapy that balances maternal needs with fetal safety. This gap
Gregory W. Kirschen, Kevin Watt, Ahizechukwu C. Eke   +2 more
wiley   +1 more source

The Potential for CYP2D6 Inhibition Screening Using a Novel Scintillation Proximity Assay-Based Approach [PDF]

, 2001
Enock Delaporte, Donald E. Slaughter, Marjorie A. Egan, Gregory J. Gatto, Albie Santos, Joanne Shelley, Elizabeth Price, Leighton Howells, Dennis Dean, A. David Rodrigues   +9 more
openalex   +1 more source

Variations and expression features of CYP2D6 contribute to schizophrenia risk [PDF]

, 2020
Liang Ma, Anna Shcherbina, Sundari Chetty   +2 more
openalex   +1 more source

Pharmacogenomic Calling From Whole‐Exome Sequencing in the Taiwanese Population—A Real‐World Experience

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
This study evaluated pharmacogenomic (PGx) calling from whole‐exome sequencing (WES) in 3562 Taiwanese individuals. Fourteen pharmacogenes were reliably identified, with each person carrying an average of ~2.4 actionable phenotypes. The high actionable frequencies of G6PD deficiency and HLA‐B*58:01 highlight ethnic differences and support WES as a ...
Hsu‐Heng Lin, Meng‐Ju Melody Tsai, Hui‐An Chen, Rai‐Hseng Hsu, Yun‐Syuan Lin, Yi‐Lin Lin, Ching Hsu, Yin‐Hsiu Chien, Wuh‐Liang Hwu, Ni‐Chung Lee   +9 more
wiley   +1 more source

The Effect of CYP2D6 Polymorphisms on the Response to Pain Treatment for Pediatric Sickle Cell Pain Crisis

, 2007
David C. Brousseau, D. Gail McCarver, Amy L. Drendel, Karthika Divakaran, Julie A. Panepinto   +4 more
openalex   +1 more source

Photophysical and DNA‐Binding Properties of Phenoxazine‐Based Push–Pull Type Organic Chromophores: Insights From DFT, Molecular Docking, and Optical Studies

ChemistryOpen, Volume 15, Issue 1, January 2026.
This study investigates the interaction of phenoxazine‐based organic dyads (PO1, PO2, PO4, and PO5) with calf thymus DNA using UV–visible spectroscopy, theoretical HOMO–LUMO analysis, and molecular docking techniques. The results reveal strong DNA‐binding interactions of these dyads, particularly PO5, highlighting their potential in biochemical and ...
Praveen Naik, T Aravinda, Kuruvalli Gouthami, Vaddi Damodara Reddy, B Vinay Kumar, Neela H. Yennawar, Kavya S. Keremane   +6 more
wiley   +1 more source

Transfer learning enables prediction of CYP2D6 haplotype function

, 2020
Gregory McInnes
openalex   +2 more sources