Results 141 to 150 of about 44,894 (310)

Sequence-based Analysis of the CYP2D6*36-CYP2D6*10 Tandem-type Arrangement, a Major CYP2D6*10 Haplotype in the Japanese Population

Drug Metabolism and Pharmacokinetics, 2006
The frequency of the CYP2D6*10 allele (100C>T) in the Japanese is relatively high (0.3-0.4), and the two *10-related genes, Ch1 (currently *10B) and Ch2 (*36), and their tandem arrangement Ch(2)-Ch(1) (*36-*10B) have been reported. Although the tandem form of *36-*10 is assumed to be a major form, no detailed information has been reported for its ...
SOYAMA, Akiko, SAITO, Yoshiro, KUBO, Takashi, MIYAJIMA, Atsuko, OHNO, Yasuo, KOMAMURA, Kazuo, UENO, Kazuyuki, KAMAKURA, Shiro, KITAKAZE, Masafumi, TOMOIKE, Hitonobu, OZAWA, Shogo, SAWADA, Jun-ichi   +11 more
openaire   +2 more sources

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Distribution of CYP2D6 multiplication, CYP2D6*5, and clinical implications in postoperative patients receiving tramadol analgesia in the Minangkabau ethnic group, Indonesia [version 3; peer review: 2 approved]

F1000Research
Background Cytochrome P450 2D6 (CYP2D6) is an important enzyme that metabolizes commonly used drugs, such as tramadol hydrochloride. Genetic polymorphisms of CYP2D6 have been shown to influence the pharmacodynamic properties of administered drugs.
Nuruliawaty Utami, Bagus Dermawan, Asrul Muhammad Fuad, Aufa Rizqia Haz, Rinal Effendi, . Desriani   +5 more
doaj   +1 more source

Enriching Medication Review with a Pharmacogenetic Profile – A Case of Tamoxifen Adverse Drug Reactions

Pharmacogenomics and Personalized Medicine, 2021
Chiara Jeiziner,1 Céline K Stäuble,1,2 Markus L Lampert,1 Kurt E Hersberger,1 Henriette E Meyer zu Schwabedissen2 1Pharmaceutical Care Research Group, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland ...
Jeiziner C, Stäuble CK, Lampert ML, Hersberger KE, Meyer zu Schwabedissen HE   +4 more
doaj  

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source

Functional characterization of wild-type and 24 CYP2D6 allelic variants on gefitinib metabolism in vitro

, 2017
Ping Fang,1 Xiang Zheng,1 Jiayang He,1 Honglei Ge,1 Pengfei Tang,1 Jianping Cai,2 Guoxin Hu1 1Department of Pharmacology, School of Pharmacy, Wenzhou Medical University, Wenzhou, Zhejiang, 2The Ministry of Health (MOH) Key Laboratory of Geriatrics ...
Ge HL, Cai JP, Zheng X, He JY, Hu GX, Fang P, Tang PF   +6 more
core  

Prevalencia de mutaciones CYP2D6 en enfermedad de Parkinson esporádica: estudio caso-control

Anales del Sistema Sanitario de Navarra, 2009
Los factores genéticos parecen tener un papel importante en el desarrollo de la enfermedad de Parkinson. La degeneración de la sustancia negra, característica de esta enfermedad, puede deberse al efecto tóxico de sustancias derivadas del metabolismo ...
D. Guerrero, M. García-Delgado, R. Larumbe, J.L. Vizmanos, F.J. Novo, J.J. Viñes   +5 more
doaj   +1 more source

Pharmacokinetic and Pharmacodynamic Interactions Between Anti‐Asthma Drugs and Medicinal Plants: A Comprehensive Review

Phytotherapy Research, EarlyView.
ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit, Aylin Bülbül, Betul Kocaadam‐Bozkurt, Osman Bozkurt, Duygu Ağagündüz, Raffaele Capasso   +5 more
wiley   +1 more source

Effect of Chiral Isomers Quinidine and Quinine Analogues on CYP2D6 Inhibition - A QSAR Investigation

, 2008
Quinidine and quinine are the chiral isomers and CYP2D6 inhibitors. The stereochemistry difference results in the different inhibitory activity with quinidine being 2 orders of magnitude more potent than quinine.
艾纯芝, 杨凌, 邹汉法
core  

CYP2D6 polymorphism and its clinical implications [PDF]

, 2010
Artículo de InvestigaciónAbstract. CYP2D6 is the most important enzyme in the metabolism of drugs and is responsible for the metabolism of 25% of all drugs currently available on the market.
Lares Asseff, Ismael, Sosa Macias, Martha   +1 more
core   +1 more source