Results 161 to 170 of about 44,894 (310)

Effects of CYP2D6 and CYP3A5 polymorphisms on tamoxifen and its metabolites in Thai breast cancer patients

, 2017
Wanaporn Charoenchokthavee,1 Nutthada Areepium,2 Duangchit Panomvana,2 Virote Sriuranpong2 1Department of Pharmacy Practice, Faculty of Pharmaceutical Science, Chulalongkorn University, 2Medical Oncology Unit, Department of Medicine, Faculty of Medicine,
Charoenchokthavee W, Areepium N, Panomvana D, Sriuranpong V   +3 more
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Respiratory depression with tramadol in a patient with renal impairment and CYP2D6 gene duplication

, 2008
We observed opioid-related respiratory depression in a patient receiving tramadol via patient-controlled analgesia. Predisposing factors were the patient's genetic background and renal impairment. Complete recovery occurred after naloxone administration,
Stüber, Frank, Musshoff, Frank, Frank Musshoff, Frank Stüber, Muders, Thomas, Ulrike M. Stamer, Stamer, Ulrike M, Thomas Muders   +7 more
core   +1 more source

A role for Cyp2d6 in nicotine metabolism?

, 2001
Nicotine is known to be metabolised to its major metabolite cotinine by members of the cytochrome P450 monooxygenase superfamily. Although CYP2A6 has now been identified as the principal enzyme which catalyses this biotransformation, CYP2D6 is also an ...
Smith, Gillian; id_orcid, Sachse, Christoph   +1 more
core   +3 more sources

Guideline for Medication Management of Distressing Symptoms in Older Patients Receiving End‐of‐Life Palliative Care

Journal of Evidence-Based Medicine, EarlyView.
ABSTRACT Older patients receiving end‐of‐life palliative care often present with multiple geriatric syndromes, frailty, and comorbid symptom burden, resulting in a high risk of medication‐related harm. This guideline focuses on pharmacological management of distressing symptoms in older patients receiving end‐of‐life or hospice‐oriented palliative care,
Daiping Li, Yanwu Yang, Yan Zhang, Jirong Yue, Birong Dong, Meiling Ge, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University   +7 more
wiley   +1 more source

The correlation between CYP2D6 isoenzyme activity and haloperidol efficacy and safety profile in patients with alcohol addiction during the exacerbation of the addiction

, 2016
Dmitry Alekseevich Sychev,1 Mikhail Sergeevich Zastrozhin,1–3 Valery Valerieevich Smirnov,4 Elena Anatolievna Grishina,1 Ludmila Mikhailovna Savchenko,1 Evgeny Alekseevich Bryun1,2 1Russian Medical Academy of Postgraduate Education, Ministry of ...
Smirnov VV, Sychev DA, Zastrozhin MS, Grishina EA, Savchenko LM, Bryun EA   +5 more
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Integrating Pharmacogenomic Testing Within the 4Ms Framework for Management of Behavioral Symptoms in Advanced Vascular Dementia: A Case Study

Journal of the American Geriatrics Society, EarlyView.
Pharmacogenomic‐guided managment of behavioral symptoms within the 4Ms framework.
Gianna Franco, Collins Njoku, Mary L. Wagner, Fred A. Kobylarz   +3 more
wiley   +1 more source

Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene–drug interaction between CYP2D6 and opioids (codeine, tramadol and oxycodone)

European Journal of Human Genetics, 2021
M. Matic, M. Nijenhuis, Bianca Soree, Nienke J. de Boer-Veger, Anne M. Buunk, E. Houwink, H. Mulder, G. Rongen, J. van der Weide, B. Wilffert, J. Swen, H. Guchelaar, V. Deneer, R. V. van Schaik   +13 more
semanticscholar   +1 more source

Влияние изофермента CYP2D6 на метаболизм лекарственных препаратов и методы определения его активности [PDF]

, 2018
The article presents relevant information on the features of cytochrome P450 isoenzyme CYP2D6 functioning. 20-25% of drugs are metabolized by the action of CYP2D6.
R. A. Permyakov, E. A. Egorenkov, R. H. Abdrashitov, Рустем Хамзиевич Абдрашитов, G. N. Gildeeva, Гэлия Нязыфовна Гильдеева, Галина Владиславовна Раменская, V. V. Smirnov, Валерий Валерьевич Смирнов, Роман Александрович Пермяков, Евгений Андреевич Егоренков, G. V. Ramenskaya   +11 more
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Concurrent Use of Tasipimidine Oral Solution and Fluoxetine in Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT This exploratory randomized crossover study investigated pharmacokinetic interactions, functional alertness, and cardiovascular safety of tasipimidine oral solution administered alone and in combination with fluoxetine in healthy Beagle dogs (n = 8; 4 dogs per dose level), with a 7‐day washout between phases. Dogs received single oral doses of
Jenni Lindstedt, Jouko M. Levijoki, Johanna Tuunainen, Jens Häggström, Meri Ramela, Mira Korpivaara   +5 more
wiley   +1 more source

CYP2D6 phenotypes are associated with adverse outcomes related to opioid medications

, 2017
Jennifer L St Sauver,1,2 Janet E Olson,1,3 Veronique L Roger,1,2,4 Wayne T Nicholson,5 John L Black III,3,6 Paul Y Takahashi,7 Pedro J Caraballo,7 Elizabeth J Bell,2 Debra J Jacobson,1,2 Nicholas B Larson,1 Suzette J Bielinski,1,3 1Department of Health ...
Takahashi PY, Jacobson DJ, St Sauver JL, Roger VL, Bielinski SJ, Nicholson WT, Black III JL, Bell EJ, Larson NB, Olson JE, Caraballo PJ   +10 more
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