Results 1 to 10 of about 873 (113)
CYP1A2 mRNA Expression Rather Than Genetic Variants Indicate Hepatic CYP1A2 Activity [PDF]
Pharmaceutics, 2022 CYP1A2, one of the most abundant hepatic cytochrome P450 enzymes, is involved in metabolism of several drugs and carcinogenic compounds. Data on the significance of CYP1A2 genetic polymorphisms in enzyme activity are highly inconsistent; therefore, the ...
Katalin Monostory, Katalin Tóth
exaly +5 more sources
The involvement of CYP1A2 in biodegradation of dioxins in pigs.
PLoS ONE, 2022 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is one of the most harmful chemicals showing resistance to biodegradation. The majority of TCDD effects is mediated by the aryl hydrocarbon receptor (AhR) pathway.
Sylwia Swigonska +3 more
doaj +3 more sources
4-Aminobiphenyl-Induced Liver and Urinary Bladder DNA Adduct Formation in Cyp1a2(-/-) and Cyp1a2(+/+) Mice. [PDF]
Journal of the National Cancer Institute, 2003 Metabolites of the potent human carcinogen 4-aminobiphenyl (ABP) induce oxidative stress and form DNA adducts that are associated with hepatic and urinary bladder toxicity and bladder tumorigenesis. Results of in vitro and cell culture studies have suggested that cytochrome P450 1A2 (CYP1A2) is the major metabolic activator of ABP.
Mario Medvedovic +2 more
exaly +3 more sources
Pathway-targeted pharmacogenomics of CYP1A2 in human liver [PDF]
Frontiers in Pharmacology, 2010 The human drug metabolizing cytochrome P450 (CYP) 1A2, is one of the major P450 isoforms contributing by about 5-20% to the hepatic P450 pool and catalyzing oxidative biotransformation of up to 10% of clinically relevant drugs including clozapine and ...
Kathrin eKlein +5 more
doaj +3 more sources
Toxic clozapine level as first indication of severe, acute infection [PDF]
Mental Health Clinician, 2022 Background: Clozapine levels can be influenced by many factors, including pharmacogenomic variability, pharmacokinetic drug interactions, and infection/inflammation.
Erica A. K. Davis, PharmD, BCPS, BCPP +2 more
doaj +1 more source
Uroporphyria in the Cyp1a2−/− mouse [PDF]
Blood Cells, Molecules, and Diseases, 2011 Cytochrome P4501A2 (Cyp1a2) is important in the development of uroporphyria in mice, a model of porphyria cutanea tarda in humans. Heretofore, mice homozygous for the Cyp1a2-/- mutation do not develop uroporphyria with treatment regimens that result in uroporphyria in wild-type mice.
John D, Phillips +3 more
openaire +2 more sources
Biochemical Journal, 2021 Previous studies showed that cytochrome P450 1A2 (CYP1A2) forms a homomeric complex that influences its metabolic characteristics. Specifically, CYP1A2 activity exhibits a sigmoidal response as a function of NADPH-cytochrome P450 reductase (POR) concentration and is consistent with an inhibitory CYP1A2•CYP1A2 complex that is disrupted by increasing ...
Aratrika Saha +4 more
openaire +2 more sources
Indian Journal of Psychological Medicine, 2020 Since 1997, studies have found that Asians need lower clozapine doses than Caucasians. Caucasians with average clozapine metabolism may need from 300 to 600 mg/day to reach the therapeutic range (350 ng/ml). Thus, serum clozapine concentration-to-dose (C/
Jose de Leon +12 more
doaj +1 more source
In vitro study on the effect of peucedanol on the activity of cytochrome P450 enzymes
Pharmaceutical Biology, 2021 Context Peucedanol is a major extract of Peucedanum japonicum Thunb. (Apiaceae) roots, which is a commonly used herb in paediatrics. Its interaction with cytochrome P450 enzymes (CYP450s) would lead to adverse effects or even failure of therapy ...
Cun Zhang +4 more
doaj +1 more source
Pharmacogenetic Markers of Favipiravir Safety in COVID-19 Treatment
Антибиотики и Химиотерапия, 2023 The aim of the study was to evaluate the associations of different variants of AOX1 and CYP1A2 genes with safety parameters of favipiravir therapy in patients with COVID-19. Material and Methods.
I. I. Temirbulatov +8 more
doaj +1 more source