Prognostic Value of CYP1A2 (rs2069514 and rs762551) Polymorphisms in COVID-19 Patients
Balkan Journal of Medical Genetics, 2023 The aim of the study was to examine the genotype-allele determination of CYP1A2 rs2069514 and rs762551 polymorphisms in patients with mild and severe COVID-19 and to determine their effectiveness as prognostic criteria in COVID-19.
Bozkurt I +4 more
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The potential influence of estrogen-containing oral contraception on clozapine metabolism in a patient with known pharmacogenomic status [PDF]
Mental Health ClinicianClozapine is primarily metabolized via cytochrome P450(CYP)1A2 and to a lesser extent CYP3A4, CYP2C19, and CYP2D6. Metabolic inhibitors of clozapine, such as fluvoxamine and ciprofloxacin, are important to recognize to avoid adverse drug events. Estrogen-
Alyssa K. Kuhn +4 more
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CYP1A2 Gene Polymorphism and Theophylline Level in Asthma [PDF]
, 2019 BACKGROUND: Aminophylline (theophylline) is one of the most frequent asthma therapies in Indonesia, although it remains as a narrow therapy. The effects of drugs are individualized and strongly influenced by genetic, one of which is CYP1A2 gene ...
Tri Murti Andayani +10 more
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Scientific Reports, 2023 Olanzapine is a commonly prescribed atypical antipsychotic agent for treatment of patients with schizophrenia and bipolar disorders. Previous in vitro studies using human liver microsomes identified CYP1A2 and CYP2D6 enzymes being responsible for CYP ...
Ferenc Fekete +9 more
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In vitro inhibitory effects of kaempferitrin on human liver cytochrome P450 enzymes
Pharmaceutical Biology, 2019 Context: Kaempferitrinis (KF) is a bioactive flavonoid and possesses numerous pharmacological activities. However, whether KF affects the activity of human liver cytochrome P450 (CYP) enzymes remains unclear.
Ning Zhang +3 more
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Study of the effect of anxiolytic GML-1 on the activity of cytochrome CYP2C9 and CYP1A2 isoforms
Фармакокинетика и Фармакодинамика, 2019 Resume. Effects of GML-1 compound on activity of isoforms CYP2C9 and CYP1A2 of cytochrome P450 using marker drugs losartane and caffeine in experiments on rats were studied.
O. G. Gribakina +6 more
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quantitative assessment of the influence of cytochrome P450 1A2 gene polymorphism and colorectal cancer risk. [PDF]
PLoS ONE, 2013 Cytochrome P450 1A2 (CYP1A2) encodes a member of the cytochrome P450 superfamily of enzymes, which play a central role in activating and detoxifying many carcinogens and endogenous compounds thought to be involved in the development of colorectal cancer (
Yuan Zhao +7 more
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The Impact of CYP1A2 and CYP2E1 Genes Polymorphism on Theophylline Response [PDF]
Journal of Clinical and Diagnostic Research, 2016 Theophylline is a medicine with narrow therapeutic index. This implies that a small change in dosage would cause side effects. Theophylline is metabolized by CYP1A2 and CYP2E1.
Em Sutrisna
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Immobilization stress increased cytochrome P450 1A2 (CYP1A2) expression in the ovary of rat
Journal of Animal Reproduction and Biotechnology, 2021 Under the stressed condition, a complex feedback mechanism for stress is activated to maintain homeostasis of the body and secretes several stress hormones.
Jong-Chan Hwang +12 more
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Journal of Animal Reproduction and Biotechnology, 2020 Cytochrome P450 1A2 (CYP1A2) is a member of the cytochrome P450 superfamily enzymes in mammals and plays a major role in metabolizing endogenous hormones in the liver.
Jong-Chan Hwan +12 more
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