Results 11 to 20 of about 5,995 (180)
Genetic polymorphisms of cytochrome P450-1A2 (CYP1A2) among Emiratis.
PLoS ONE, 2017 Cytochrome P450 1A2 (CYP1A2) is one of the CYP450 mixed-function oxidase system that is of clinical importance due to the large number of drug interactions associated with its induction and inhibition.
Mohammad M Al-Ahmad +6 more
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Coffee, CYP1A2 genotype and risk of myocardial infarction [PDF]
Genes & Nutrition, 2006 The association between coffee intake and risk of myocardial infarction (MI) remains controversial. Coffee is a major source of caffeine, which is metabolized by the polymorphic cytochrome P450 1A2 (CYP1A2) enzyme. Individuals who are homozygous for the CYP1A2*1A allele are "rapid" caffeine metabolizers, whereas carriers of the variant CYP1A2*1F are ...
Cornelis, Marilyn C. +3 more
openaire +7 more sources
Clinical and Translational Science, 2019 The caffeine metabolic ratio is an established marker for cytochrome P450 (CYP) 1A2 activity. Optimal sample size calculation for clinical pharmacokinetic xenobiotic–caffeine interaction studies requires robust estimates of interindividual and ...
Dan‐Dan Tian +3 more
doaj +2 more sources
BMC CancerBackground Bladder cancer (BLCA) poses a significant global health challenge due to its high incidence, poor prognosis, and limited treatment options. Aims and objectives This study aims to investigate the association between two specific polymorphisms ...
Muhammad Sarfaraz Iqbal +8 more
doaj +2 more sources
The effect of the CYP1A2 *1F mutation on CYP1A2 inducibility in pregnant women [PDF]
British Journal of Clinical Pharmacology, 2002 Aims To investigate the influence of the CYP1A2*1F mutation on CYP1A2 activity in smoking and nonsmoking pregnant women.Methods Pregnant women (n = 904) who served as control subjects in a case‐control study of early fetal loss were investigated. They were phenotyped for CYP1A2 using dietary caffeine and the urinary ratio AFMU + 1X + 1 U/1,7 U.
Anna, Nordmark +4 more
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Involvement of CYP1A2 in mexiletine metabolism [PDF]
British Journal of Clinical Pharmacology, 1998 Aims Mexiletine has been reported to be hydroxylated by cytochrome P450 2D6 (CYP2D6) in humans. However, the involvement of CYP1A2 in the metabolism of mexiletine has been proposed based on the interaction with theophylline which is mainly metabolized by CYP1A2.
M, Nakajima +5 more
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Baltic Journal of Health and Physical Activity, 2022 Introduction: This systematic review aims to examine the effects of the CYP1A2 −163C>A and ADORA2A 1976T>C polymorphism on physiological effects and performance relative to caffeine consumption.
Rümeysa Rabia Kocatürk +6 more
doaj +1 more source
Parkinson's disease and CYP1A2 activity [PDF]
British Journal of Clinical Pharmacology, 2000 Aims MPTP, a neurotoxin which induces parkinsonism is partially metabolized by the enzyme CYP1A2. Smoking appears to protect against Parkinson's disease (PD) and cigarette smoke induces CYP1A2 activity. Thus, we investigated the hypothesis that idiopathic PD is associated with lower CYP1A2 activity using caffeine as a probe ...
J T, Forsyth +5 more
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Inducibility of CYP1A2 by omeprazole in vivo related to the genetic polymorphism of CYP1A2 [PDF]
British Journal of Clinical Pharmacology, 2002 Aims To evaluate the effect of the CYP1A2*1C and CYP1A2*1F polymorphisms on the inducibility of CYP1A2 by omeprazole in healthy subjects.Methods Mutations of CYP2C19 and CYP1A2 were identified by PCR‐RFLP. Omeprazole, 120 mg day−1, was given to 12 extensive metabolizers (EM) with respect to CYP2C19 (six CYP1A2*1F/CYP1A2*1F and six CYP1A2*1C/CYP1A2*1F
Xing-Mei, Han +6 more
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Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2021 Antipsychotic-induced parkinsonism is an undesirable reaction from the extrapyramidal system that occurs against the background of taking antipsychotics (AP), more often in patients with schizophrenia.
E. E. Vaiman +3 more
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