Results 31 to 40 of about 5,995 (180)

The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine [PDF]

British Journal of Clinical Pharmacology, 1997
Aims Clozapine (CLZ), an atypical neuroleptic with a high risk of causing agranulocytosis, is metabolized in the liver to desmethylclozapine (DCLZ) and clozapine N‐oxide (CLZ‐NO). This study investigated the involvement of different CYP isoforms in the formation of these two metabolites. Methods Human liver microsomal incubations, chemical inhibitors,
B, Eiermann, G, Engel, I, Johansson, U M, Zanger, L, Bertilsson   +4 more
openaire   +2 more sources

Prevalence of AOX1 and CYP1A2 gene polymorphisms associated with response to favipiravir therapy in novel coronavirus infection COVID-19 among ethnic groups of the North Caucasus

Фармация и фармакология (Пятигорск)
Drug sensitivity to, in particular to favipiravir, may vary among representatives of different ethnic groups. Studies have previously shown that carrying certain variants of the AOX1 and CYP1A2 genes may be associated with an increased incidence of ...
A. T. Leinsoo, N. P. Denisenko, Sh. P. Abdullaev, S. N. Tuchkova, A. V. Kryukov, S. N. Mammaev, Zh. A. Sozaeva, M. S.-Kh. Sozaeva, K. A. Akmalova, L. Z. Bolieva, A. I. Dobroselskaya, M. L. Maksimov, K. B. Mirzaev, D. A. Sychev   +13 more
doaj   +1 more source

Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 82-96).Efavirenz (EFV) is used in first-line antiretroviral (ARV) therapy of HIV-infected patients, and is principally metabolised by CYP1A2, CYP2A6, CYP2B6, CYP3A4/5 and the drug transporter ...
Swart, Marelize
core   +1 more source

Heat stress-induced CYP1A2 upregulation in sow ovarian granulosa cells

Journal of Animal Reproduction and Biotechnology
Background: Heat stress during summer impairs reproductive performance in sows, causing summer infertility. Cytochrome P450 1A2 (CYP1A2) plays a crucial role in steroid hormone metabolism in the liver and has been shown to be upregulated under stress ...
Tae-Gyun Kim, Hyun-Seung Lee, Sung-Ho Kim, Young-Bum Son, Seong-Eun Heo, Do-Yoon Kim, Seung-Joon Kim, Won-Jae Lee   +7 more
doaj   +1 more source

Cyp1a2 Genetic Polymorphisms Are Associated with Treatment Response to the Antidepressant Paroxetine

, 2012
Aim: Paroxetine is a drug of choice in the treatment of major depressive disorder MDD. Its metabolism has recently been reported to be mediated through the CYP enzymes 1A2 and 2D6.
林克明;鄒小蕙;蕭美君;蕭金福;劉嘉逸;沈武典;湯華盛;方俊凱;吳其炘;呂紹俊;郭湘維, LIN, KEH-MING;TSOU, HSIAO-HUI;HSIAO, MEI-CHUN;HSIAO, CHIN-FU;LIU, CHIA-YIH;SHEN, WINSTON W.;TANG, HWA-SHENG;FANG, CHUN-KAI;WU, CHI-SHIN;LU, SHAO-CHUN;KUO, HSIANG-WEI;LIU, YU-LI   +1 more
core   +1 more source

Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone) [PDF]

, 2006
NSC686288 [aminoflavone (AF)], a candidate chemotherapeutic agent, possesses a unique antiproliferative profile against tumor cells. Metabolic bioactivation of AF by drug-metabolizing enzymes, especially CYP1A monooxygenases, has been implicated as an ...
Ma, Xiaochao, Krausz, Kristopher W, Gonzalez, Frank J, Meng, Linghua, Pommier, Yves, Idle, Jeffrey R, Chen, Chi, Idle, Jeffrey   +7 more
core   +1 more source

Human genetic variation with implications for healthcare in Ethiopian populations [PDF]

, 2010
Cytochrome P450 1A2 metabolizes a wide range of therapeutic drugs, including several used to treat diseases common in sub-Saharan Africa. Variation in the gene (CYP1A2) has been reported to be associated with differential efficacy of therapeutic drugs ...
Browning, S.L.
core  

Does celecoxib inhibit agomelatine metabolism via CYP2C9 or CYP1A2?

, 2018
Umit Yasar Department of Medical Pharmacology, Hacettepe University, Faculty of Medicine, Ankara, TurkeyHe et al have reported inhibitory effect of celecoxib on agomelatine metabolism in rat/human liver microsomes, recombinant human cytochrome P450 (CYP)
Yasar U, Yasar, Umit
core   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Polymorphisms of CYP1A1, CYP1A2, CYP19, and SULT1A1 genes in women with early miscarriage

Фундаментальная и клиническая медицина, 2019
Aim. To determine the frequency of the polymorphisms within the genes encoding estrogen metabolism enzymes: CYP1A1 (rs4646903), CYP1A2 (rs762551), CYP19 (rs700519) and SULT1A1 (rs9282861) in women with early miscarriage.Materials and Methods.
I. N. Noskova, N. V. Artymuk, L. F. Gulyaeva   +2 more
doaj   +1 more source