Results 1 to 10 of about 28,268,520 (143)
Association between low body weight and cytochrome P‐450 enzyme activity in patients with anorexia nervosa [PDF]
Pharmacology Research & Perspectives, 2020 Very little is known to which extent severe underweight could affect cytochrome P‐450 (CYP) enzyme activity. In this study, 24 patients with anorexia nervosa at two occasions ingested single oral doses of five test drugs known to be metabolized by CYP1A2,
Pål Sandvik +3 more
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A Modeling Investigation of the CYP1A Drug Interactions of Riluzole [PDF]
Clinical and Translational ScienceCytochrome‐P‐450 (CYP)1A2 has been considered the major enzyme metabolizing riluzole since its approval. However, the inhibitor that was used in the original experiments, α‐naphthoflavone, is also a potent inhibitor of CYP1A1.
Paul Malik +4 more
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Frontiers in Pharmacology, 2022 Caffeine is by far the most ubiquitous psychostimulant worldwide found in tea, coffee, cocoa, energy drinks, and many other beverages and food. Caffeine is almost exclusively metabolized in the liver by the cytochrome P-450 enzyme system to the main ...
Jan Grzegorzewski +3 more
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BMC Cancer, 2007 Background Cytochrome P450 (CYP) enzymes have the potential to affect colorectal cancer (CRC) risk by determining the genotoxic impact of exogenous carcinogens and levels of sex hormones.
Withey Laura +7 more
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PLoS ONE, 2014 Baicalin has been used as mainly bioactive constituent of about 100 kinds of traditional Chinese medicines in Chinese pharmacopoeia. The effect of baicalin on cytochrome P450 should be paid more attention because baicalin was used widely. The aim of this
Na Gao +6 more
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Inhibitory Effect of Antituberculosis Drugs on Human Cytochrome P450-Mediated Activities
Journal of Pharmacological Sciences, 2004 The potential for drug-drug interactions mediated by the inhibition of cytochrome P-450 (CYP) were concerned during antituberculosis therapy. However, the information regarding human CYP inhibition by antituberculosis drugs is limited to isoniazid.
Yuki Nishimura +3 more
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Saudi Pharmaceutical Journal, 2019 Rhei rhizome (Rheum officinale Baill.) (RR) contains a large number of anthraquinone bioactive, yet little is known of the combined effect of these anthraquinones in a mixture.
Zeyad Alehaideb +3 more
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Metabolism of six CYP probe substrates in fetal hepatocytes
ADMET and DMPK, 2016 Cytochrome P-450 (CYP) are the most common drug metabolizing enzymes and are abundantly expressed in liver apart from kidney, lungs, intestine, brain etc. Their expression levels change with physiological conditions and disease states.
Abdul Naveed Shaik +2 more
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Economic Impact of the Application of a Precision Medicine Model (5SPM) on Psychotic Patients
Pharmacogenomics and Personalized Medicine, 2021 Lorena Carrascal-Laso,1 Manuel Ángel Franco-Martín,1 Elena Marcos-Vadillo,2 Ignacio Ramos-Gallego,3 Belén García-Berrocal,2 Eduardo Mayor-Toranzo,1 Santiago Sánchez-Iglesias,4 Carolina Lorenzo,4 Alfonso Sevillano-Jiménez,1 Almudena Sánchez-Martín,5 María
Carrascal-Laso L +11 more
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MetabolitesBackground/Objectives: The prevalence of metabolic syndrome (MetS) is steadily increasing worldwide, driven by complex genetic, nutritional, and environmental factors. Caffeine metabolism, primarily mediated by CYP1A2 (though other enzymes such as CYP1A1
Laura Claudia Popa +4 more
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