Results 21 to 30 of about 28,268,520 (143)
Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.Integrated systems pharmacology and in vivo evaluation reveal that hydroalcoholic extract of fruit pulp of Prunus armeniaca (HAE of FPPA) ameliorates letrozole–HFD‐induced PCOS through multitarget modulation. Network analysis identifies 105 shared targets enriched in PI3K/Akt, MAPK, HIF‐1, and inflammatory pathways, while treatment improves hormonal ...
Ratna Priya +4 more
wiley +1 more source
A Novel Cytochrome P-450 which Catalyze ω-Hydroxylation of Prostaglandins [PDF]
, 1988 P(論文)Two forms of cytochrome P-450, designated as cytochrome P-450p-1 and P-450p-2, were separted and purified from lung microsomes of rabbits treated with progesterone.
41791, 山本, 覚
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MedComm, Volume 7, Issue 10, October 2026.The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley +1 more source
An investigation of Cytochrome P450 function in human cell Lines for potential use in a bioartificial liver device [PDF]
, 2010 Bioartificial Liver Devices (BAL) could provide hepatic function in patients with liver failure awaiting transplantation or liver regeneration. Certain BALs use human hepatoblastoma-derived HepG2 cells that can perform many hepatocyte specific ...
Thomas, A.
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In Vitro Hepatotoxicity of Routinely Used Opioids and Sedative Drugs
Current Issues in Molecular BiologyA hepatocyte cell line was used to determine the hepatotoxicity of sedatives and opioids, as the hepatotoxicity of these drugs has not yet been well characterized.
Katharina Haller +2 more
doaj +1 more source
Liver International, Volume 46, Issue 9, September 2026.ABSTRACT Background and Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a progressive liver disease that ranges from simple steatosis to inflammation, fibrosis and cirrhosis. To address the unmet need for new MASLD biomarkers, we aimed to identify candidate biomarkers using publicly available RNA sequencing (RNA‐seq) and ...
Wenfeng Ma +17 more
wiley +1 more source
High promutagen activating capacity of yeast microsomes containing human cytochrome P-450 1A and human NADPH-cytochrome P-450 reductase [PDF]
, 2017 Yeast Saccharomyces cerevisiae strains have been constructed that co-express cDNAs coding for the human cytochrome P-450 enzymes CYP1A1 or CYP1A2 in combination with human NADPH-cytochrome P-450 reductase (oxidoreductase).
Sengstag, Christian +2 more
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Food Science &Nutrition, Volume 14, Issue 8, August 2026.Wild Daucus carota subsp. Maximus: chemical investigation and biological assessment. ABSTRACT Daucus carota subsp. maximus, a biennial plant from the Apiaceae family, is valued for its aromatic properties. It is the largest wild carrot subspecies found in Algeria, characterized by its tall stem, triangular leaves, and large umbels.
Maroua Hadji +11 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 7, July 2026.This study presents a comprehensive evaluation of Hibiscus sabdariffa L. calyx extracts from Libya, integrating phytochemical profiling, multi‐target biological activities, and in silico validation. Aqueous and ethanolic extracts were prepared and assessed for antibacterial activity against multidrug‐resistant clinical isolates (MIC: 6.25–25 mg/mL; MBC/
Ahmed Saeed Kabbashi +8 more
wiley +1 more source
Protein Science, Volume 35, Issue 7, July 2026.Abstract CYP2J2 is a membrane‐bound cytochrome P450 that is expressed in cardiomyocytes, where it is known to metabolize arachidonic acid into cardioprotective epoxyeicosatrienoic acids (EETs). It consists of transmembrane domains embedded in the hydrophobic segments of the cell membrane and surrounded by various lipids.
Rajatabha Das +3 more
wiley +1 more source