Results 41 to 50 of about 28,268,520 (143)

Functional Training Mitigates Reduced Circulating Indole‐3‐Lactate Levels in Persons With Relapsing–Remitting Multiple Sclerosis

Acta Physiologica, Volume 242, Issue 3, March 2026.
ABSTRACT Aim Indoles are tryptophan (Trp)‐derived metabolites that are produced by the gut microbiota and may influence the gut‐microbiota‐brain axis in multiple sclerosis (MS). Indole‐3‐lactate (ILA) is reduced in persons with MS and improves MS clinical scores in animal models via its anti‐inflammatory remyelinating properties.
Tiffany Wences Chirino, Frederike Adammek, Sergen Belen, Matteo Winker, Sebastian Proschinger, Annette Rademacher, Marit L. Schlagheck, Alexander Schenk, Marie Kupjetz, David Walzik, Clemens Warnke, Marcel Reuter, Friederike Rosenberger, Tim Meyer, Adrian McCann, Per Magne Ueland, Niklas Joisten, Philipp Zimmer   +17 more
wiley   +1 more source

The effect of age on inducibility of various types of rat liver cytochrome P-450

, 1992
The content and specific activities of inducible cytochrome P-450 enzymes were determined in liver microscomes of rats of various ages after maximal induction with phenobarbital, isosafrole of 3-methylcholanthrene, and in untreated animals.
Kremers, P., Horbach, G.J.M.J., Asten, J.G. van, Rietjens, I.M.C.M., Bezooijen, C.F.A. van   +4 more
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Association Between Levels of the Acute Phase Proteins Alpha‐1‐Acid Glycoprotein and C‐Reactive Protein and Serum Concentrations of Clozapine: A Study of 1106 Therapeutic Drug Monitoring Samples

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
ABSTRACT Several publications have reported elevated clozapine concentrations in patients experiencing infections or inflammatory reactions. Proposed mechanisms include increased levels of pro‐inflammatory cytokines that may inhibit clozapine metabolism and enhanced binding of clozapine to the acute phase protein alpha‐1‐acid glycoprotein (AGP).
Ketil Arne Espnes, Olav Spigset, Guro Emilie Bratt, Marit Tilrem, Sarita Hamnes, Eirik Skogvoll, Ragnhild Bergene Skråstad   +6 more
wiley   +1 more source

Two Distinct Electrophilic Oxidants Effect Hydroxyl- ation in Cytochrome P-450-Catalyzed Reactions

, 2016
Two Distinct Electrophilic Oxidants Effect Hydroxyl- ation in Cytochrome P-450-Catalyzed ...
Alfin D. N. Vaz (172262), Patrick H. Toy (2184381), Minor J. Coon (2505373), Martin Newcomb (2297455)   +3 more
core   +1 more source

Purification of cytochrome P-450 in mycobacteria [PDF]

, 2002
Purification of cytochrome P-450 from Mycobacterium smegmatis, M. chelonae, M. fortuitum and M. tuberculosis H37RV was undertaken. The electrophoretic pattern revealed a single band corresponding to a molecular weight of 66 kDa in all the four ...
Gurumurthy, Prema, Ramachandran, Geetha
core   +2 more sources

An Evaluation of the Drug Interaction Potential of Encorafenib in Combination With Binimetinib Using the Inje Cocktail in Patients With Cancer

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 375-380, February 2026.
A clinical drug–drug interaction (DDI) study was designed to evaluate the effect of single and multiple oral doses of encorafenib on the single oral dose pharmacokinetics (PK) of the cytochrome P450 (CYP) enzyme probe substrates, losartan (CYP2C9), midazolam (CYP3A4), caffeine (CYP1A2), omeprazole (CYP2C19), and dextromethorphan (CYP2D6) administered ...
Joseph Piscitelli, Micaela B. Reddy, Lance Wollenberg, Laurence Del Frari, Jason Gong, Kyle Matschke, Jason H. Williams   +6 more
wiley   +1 more source

Identification of the Contact Region Responsible for the Formation of the Homomeric CYP1A2-CYP1A2 Complex

, 2021
Previous studies showed that cytochrome P450 1A2 (CYP1A2) forms a homomeric complex that influences its metabolic characteristics. Specifically, CYP1A2 activity exhibits a sigmoidal response as a function of NADPH-cytochrome P450 reductase (POR ...
Backes, Wayne L, Saha, Aratrika, Lott, Charles S, Reed, James R., Lott, Charles S., Backes, Wayne L., Connick, J. Patrick, Reed, James Robert, Connick, J Patrick   +8 more
core   +1 more source

Membrane bound cytochrome p-450 determines the optimal temperatures of NADPH - cytochrome p-450 reductase and cytochrome p-450-linked monooxygenase reactions in rat and trout hepatic microsomes

, 1985
The hepatic monooxygenase systems largely responsible for the biotransformation of drugs and other xenobiotics are comprised of NADPH-cytochrome P-450 reductase and multiple forms of cytochrome P-450.
Mannering, Gilbert J, Prema , Gurumurthy
core   +1 more source

Homology modelling of human CYP1A2 based on the CYP2C5 crystallographic template structure

, 2003
1. The results of homology modelling of human cytochrome P4501A2 (CYP1A2) based on the CYP2C5 crystal structure are reported. It exhibits improved sequence homology relative to that of CYP102. 2.
Lewis, D.F.V., Lake, B.G., Dickins, M., Goldfarb, P.S., Ueng, Y.F.   +4 more
core  

Induction and inhibition of cytochrome P-450* [PDF]

, 2009
Induction and inhibition of cytochrome P-450*
Pelkonen, Olavi
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