Results 121 to 130 of about 23,309 (224)
Acta Biológica Colombiana, 2009 RESUMEN El gen CYP2D6 codifica para una monooxigenasa perteneciente al citocromo P450, la cual está involucrada en la biotransformación de un gran número de drogas comúnmente prescritas, como antidepresivos, antineoplásicos y antihipertensivos. Algunos
PEDRO GRIMÁN +3 more
doaj
Clinical and Translational Science, Volume 19, Issue 8, August 2026.PopPK modeling and simulation workflow for metoprolol in older Chinese patients with CKM syndrome. ABSTRACT Older adults are vulnerable to adverse drug reactions due to multimorbidity, frailty and polypharmacy. In those with cardiovascular‐kidney‐metabolic (CKM) syndrome, CKM‐related multi‐organ burden may further alter drug disposition and elevate ...
Haodi Chai +8 more
wiley +1 more source
Clinical and Translational Science, Volume 19, Issue 8, August 2026.ABSTRACT Identification of modifiable risk factors for prescription opioid use disorder (OUD)‐related emergency department (ED) visits (ICD‐10 F11.xx) is a clinical priority; however, most published models remain cross‐sectional and lack pharmacogenomic (PGx) enrichment or dual‐method feature confirmation. Using Virginia All‐Payer Claims Database (APCD)
R. Jerome Dixon, Elvin T. Price
wiley +1 more source
Clinical and Translational Science, Volume 19, Issue 8, August 2026.ABSTRACT The “last mile” problem in healthcare AI—translating high‐performance models into accessible, privacy‐preserving point‐of‐care tools—remains unsolved for pharmacogenomic (PGx) risk assessment. No existing platform integrates opioid and polypharmacy risk scoring, model‐based scenario analysis, and CPIC‐based PGx patient cards within a single ...
R. Jerome Dixon, Elvin T. Price
wiley +1 more source
Experimental Models of Autoimmune Hepatitis: Disease Fidelity and Translational Relevance
Liver International, Volume 46, Issue 8, August 2026.ABSTRACT Autoimmune hepatitis (AIH) remains difficult to study mechanistically in patients because disease initiation is rarely observed directly, the relevant autoantigens differ across subsets, and clinically meaningful outcomes such as chronic inflammation, fibrosis, relapse, and treatment response evolve over time.
Laura Elisa Buitrago‐Molina +1 more
wiley +1 more source
Effects of Celecoxib and Etoricoxib on the Pharmacokinetics and Pharmacological Effects of Orally Administered Tramadol: A Randomised Controlled Trial. [PDF]
Basic Clin Pharmacol ToxicolSaarikoski T +6 more
europepmc +1 more source
Berberine and Metabolic Dysfunction‐Associated Steatotic Liver Disease: Hope or Hype?
Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
Ruth Nona, Eric Kalo
wiley +1 more source
Very strong correlations of metoprolol- and solanidine-derived metabolic ratios in a real-world cohort with a stable metoprolol drug regimen. [PDF]
Front PharmacolSarömba JA +17 more
europepmc +1 more source
Clinical CYP2D6-Mediated Pharmacokinetic Drug-Drug Interactions of DA-8010 with Paroxetine or Mirabegron in Healthy Korean Participants. [PDF]
Drug Des Devel TherRyu H, Cho JY, Lee DY, Lee S.
europepmc +1 more source