Results 121 to 130 of about 32,925 (256)
Cell Proliferation, EarlyView.The lichen‐derived metabolite methyl 4‐O‐demethylbarbatate (Me‐4‐O‐DBA) suppresses glioma stemness, motility, and metabolic plasticity through inhibition of HIF‐1α signaling and synergistically enhances temozolomide activity, highlighting a potential strategy to target stemness‐driven therapeutic resistance in glioma.
Rui Zhou +8 more
wiley +1 more source
Cloning and expression of CYP2D6*1 and CYP2D6*10 and its application in vitro drug-herbs interaction studies [PDF]
, 2013 CYP2D6 mempakan salah satu enzim CYP utama dania bertanggungjawab dalam metabolisma kira-kira 20% daripada ubat-ubatan yang terdapat pada masa kini. CY2D6 adalah berpolymorfisma dan CYP2D6* 10 mempakan alelle kebiasaan di kalangan populasi Malaysia ...
Lee, Wee Leng
core +1 more source
Journal of the American Geriatrics Society, EarlyView.Pharmacogenomic‐guided managment of behavioral symptoms within the 4Ms framework.
Gianna Franco +3 more
wiley +1 more source
Effect of Chiral Isomers Quinidine and Quinine Analogues on CYP2D6 Inhibition - A QSAR Investigation
, 2008 Quinidine and quinine are the chiral isomers and CYP2D6 inhibitors. The stereochemistry difference results in the different inhibitory activity with quinidine being 2 orders of magnitude more potent than quinine.
艾纯芝, 杨凌, 邹汉法
core
Concurrent Use of Tasipimidine Oral Solution and Fluoxetine in Dogs
Journal of Veterinary Pharmacology and Therapeutics, EarlyView.ABSTRACT This exploratory randomized crossover study investigated pharmacokinetic interactions, functional alertness, and cardiovascular safety of tasipimidine oral solution administered alone and in combination with fluoxetine in healthy Beagle dogs (n = 8; 4 dogs per dose level), with a 7‐day washout between phases. Dogs received single oral doses of
Jenni Lindstedt +5 more
wiley +1 more source
Role of the CYP2D6-genpolymorphism for safety and efficiency of CYP2D6 dependently metabolized antidepressants [PDF]
, 2008 Durch verschiedene CYP2D6-Genmutationen, welche in der Bevölkerung vorkommen, wird bei den betroffenen Personen in der Leber weniger oder kein CYP2D6-Enzym produziert.
Wohlleben, Gerlinde
core
Фармакокинетика и Фармакодинамика, 2014 В настоящем номере представлен ряд актуальных обзоров, посвящённых изучению новых лекарственных средств и межлекарственному взаимодействию. Прежде всего, продолжается серия обзоров, связанных с исследованием функционирования и полиморфизма известных ...
doaj
Oral Diseases, EarlyView.ABSTRACT Objective This narrative review critically assesses the clinical relevance of pharmacogenomics within dental genomics, distinguishing clinically actionable applications from emerging or investigational findings. Materials and Methods A targeted literature review was conducted in PubMed/MEDLINE, Scopus and Embase for publications from January ...
Giorgia Pieretto +3 more
wiley +1 more source
Фармакокинетика и Фармакодинамика, 2014 Peculiarities of functioning and polymorphism of cytochrome P450 isoenzyme CYP2D6. Existing methods for determining its activity using endogenous markers.
A. D. Abdrashitov +3 more
doaj
Journal of Applied Toxicology, Volume 46, Issue 12, Page 4396-4408, December 2026.ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto +7 more
wiley +1 more source