Results 111 to 120 of about 44,899 (264)
Succinic acid inhibits the activity of cytochrome P450 (CYP450) enzymes
Pharmaceutical Biology, 2020 Context Succinic acid, extracted from amber, is widely used in cardiovascular therapy. Objective The effect of succinic acid on the activity of cytochrome P450 (CYP450) enzymes was investigated in this study.
Hao Wang +5 more
doaj +1 more source
Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children [PDF]
, 2017 Low-dose primaquine is recommended to prevent Plasmodium falciparum malaria transmission in areas threatened by artemisinin resistance and areas aiming for malaria elimination.
Bousema, Teun +8 more
core +2 more sources
Journal of Applied Toxicology, EarlyView.ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto +7 more
wiley +1 more source
Pharmaceutics, 2019 Tramadol is a μ-opioid receptor agonist and a monoamine reuptake inhibitor. O-desmethyltramadol (M1), the major active metabolite of tramadol, is produced by CYP2D6.
Hyeon-Cheol Jeong +6 more
doaj +1 more source
Genetic polymorphism of CYP2D6 influences susceptibility to papillary thyroid cancer [PDF]
, 2007 OBJECTIVE: Xenobiotic-metabolizing enzymes are widely polymorphic and confer interindividual variation in the ability to detoxify carcinogens or to activate pro-carcinogens.
Carrilho, F +6 more
core +1 more source
Journal of the Chinese Chemical Society, EarlyView.Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley +1 more source
Journal of Heterocyclic Chemistry, EarlyView.N‐nitrosamine impurities (B, C, E, H, I, J) of timolol maleate are easily synthesized from diethyl malonate and 3,4‐dichloro‐1,2,5‐thiadiazole. Good yields and precise impurity profiling are made possible by the effective technique, which also ensures pharmaceutical safety and strengthens regulatory compliance.
Kottolla Sai Prasad +3 more
wiley +1 more source
Characterization of hepatic enzyme activity in older adults with dementia: potential impact on personalizing pharmacotherapy [PDF]
, 2015 OBJECTIVE: To determine the frequency of pharmacogenomic variants and concurrent medications that may alter the efficacy and tolerability of acetylcholinesterase inhibitors (AChEIs).
Boustani, Malaz A. +6 more
core +2 more sources
The CYP2D6 VCF Translator [PDF]
The Pharmacogenomics Journal, 2016 W, Qiao +5 more
openaire +2 more sources
Codeine and Metabolite Concentrations in the Breastfed Neonate
Pediatric Anesthesia, EarlyView.ABSTRACT Analgesic effect from codeine is from its metabolite, morphine. Morphine is formed by the O‐demethylation of codeine and that enzyme is controlled by the cytochrome P450 2D6. More than 60 alleles in the CYP2D6 gene have been identified. This spectrum of polymorphism can be categorized into four groups: poor (PM), intermediate (IM), normal (NM),
Brian J. Anderson, Jacqueline A. Hannam
wiley +1 more source