Results 111 to 120 of about 32,925 (256)

Functional characterization of wild-type and 24 CYP2D6 allelic variants on gefitinib metabolism in vitro

open access: yes, 2017
Ping Fang,1 Xiang Zheng,1 Jiayang He,1 Honglei Ge,1 Pengfei Tang,1 Jianping Cai,2 Guoxin Hu1 1Department of Pharmacology, School of Pharmacy, Wenzhou Medical University, Wenzhou, Zhejiang, 2The Ministry of Health (MOH) Key Laboratory of Geriatrics ...
Ge HL   +6 more
core  

Изучение активности CYP2D6 по оценке фармакокинетики амитриптилина у носителей аллельного варианта CYP2D6*4

open access: yes, 2008
Савельева М.И., Сычев Д.А. Proceedings of the III Congress of Pharmacology Russia, Saint-Petersburg, 23–27 September 2007. Abstr 569. Psychopharmacol Biol Narcol 2007 Sept; 7 Suppl (Pt 2, M–Ja): 2-1931–2-1931 [in Russian]Савельева М.И.,
Д. А. Сычев; Московская медицинская академия им. И.М. Сеченова Росздрава; Яузская ул., 11, корп. 4, Москва, 109240; ГКБ № 23 им. «Медсантруд»   +1 more
core   +1 more source

Pharmacokinetic and Pharmacodynamic Interactions Between Anti‐Asthma Drugs and Medicinal Plants: A Comprehensive Review

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit   +5 more
wiley   +1 more source

Prevalence of CYP2D6*2, CYP2D6*4, CYP2D6*10, and CYP3A5*3 in Thai breast cancer patients undergoing tamoxifen treatment

open access: yes, 2016
Wanaporn Charoenchokthavee,1 Duangchit Panomvana,1 Virote Sriuranpong,2 Nutthada Areepium1 1Department of Pharmacy Practice, Faculty of Pharmaceutical Science, 2Medical Oncology Unit, Department of Medicine, Faculty of Medicine, Chulalongkorn University,
Charoenchokthavee W   +3 more
core  

CYP2D6 polymorphism screening in a selected population of Spain (La Alpujarra): no effect of geographical isolation

open access: yes, 2009
Background: Aim: Subjects and Methods: Results: Conclusion: There is growing interest in the CYP2D6 gene because of its key role in the metabolism of numerous commonly used drugs.We compared the frequency of the most frequent null CYP2D6 alleles (CYP2D6 ...
Bandrés Moya, Fernando   +23 more
core   +1 more source

Prevalencia de mutaciones CYP2D6 en enfermedad de Parkinson esporádica: estudio caso-control

open access: yesAnales del Sistema Sanitario de Navarra, 2009
Los factores genéticos parecen tener un papel importante en el desarrollo de la enfermedad de Parkinson. La degeneración de la sustancia negra, característica de esta enfermedad, puede deberse al efecto tóxico de sustancias derivadas del metabolismo ...
D. Guerrero   +5 more
doaj   +1 more source

Multi‐Target Pharmacological Mechanisms of Salvia miltiorrhiza Bunge in Metabolic Syndrome and Cardiovascular Diseases: A Comprehensive Review Based on the Theory of “Same Treatment for Different Diseases”

open access: yesPhytotherapy Research, EarlyView.
Salvia miltiorrhiza Bunge in metabolic syndrome and cardiovascular diseases: multi‐target actions on shared signaling pathways. ABSTRACT Metabolic syndrome (MetS) represents a clinical disorder characterized by the clustering of conditions including obesity, elevated blood sugar levels, and high lipid levels, which are intricately linked to the onset ...
Zhiyi Jia   +6 more
wiley   +1 more source

Novel +90G>A Intronic Polymorphism of CYP2D6.

open access: yesCell journal, 2015
CYP2D6, an enzyme, metabolizes a large number of commonly prescribed drugs. Variations in CYP2D6 gene encoding this enzyme have been associated with individual differences in drug metabolism rates. The purpose of our study was to identify some allelic variants of CYP2D6 gene and to detect defective CYP2D6 alleles, as part of a pharmacogenetic screening
Modaresinejad, Monir   +2 more
openaire   +3 more sources

Variantes alélicas de CYP2D6: *4, *6 y *10 en una muestra de residentes del estado Aragua, Venezuela

open access: yesRevista Peruana de Medicina Experimental y Salud Pública
El objetivo del estudio fue determinar la frecuencia de las variantes del gen CYP2D6: *4, *6 y *10 y predecir el fenotipo metabolizador en una muestra de 145 individuos no consanguíneos, aparentemente sanos, residentes del estado Aragua, Venezuela.
Carlos Flores-Angulo   +5 more
doaj   +2 more sources

Liver Organoids: From Disease Modelling to Regenerative Medicine

open access: yesCell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang   +5 more
wiley   +1 more source

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