Results 131 to 140 of about 44,894 (310)

CYP2D6 polymorphisms and their influence on risperidone treatment

, 2016
Apichaya Puangpetch,1 Natchaya Vanwong,1 Nopphadol Nuntamool,2 Yaowaluck Hongkaew,1 Monpat Chamnanphon,1 Chonlaphat Sukasem1 1Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital ...
Puangpetch A, Hongkaew Y, Chamnanphon M, Sukasem C, Nuntamool N, Vanwong N   +5 more
core  

Biological Effects of Selenium‐Containing Ionic Liquids: Cytotoxicity, Mercury Interaction, and Antiproliferative Activity in Glioblastoma Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Selenium (Se) is an essential micronutrient that participates in redox regulation and cellular homeostasis. Selenium‐containing ionic liquids (ILsSe) have emerged as hybrid compounds combining the properties of organoselenium molecules with the tunable features of ionic liquids.
Guilherme Schmitt Rieder, Alessandro de Souza Prestes, Fernanda D'Avila da Silva, Nilda de Vargas Barbosa, Alix Y. Bastidas Ángel, Mariana F. Soares, Carolina Martins Fernandes, Maria Anttônia Oliveira Petersen, Manuela Moura Silva, Juliete Nathali Scholl, Fabrício Figueiró, Pablo Andrei Nogara, Laura Orian, Eduardo E. Alberto, Michael Ascnher, Diogo Onofre Gomes de Souza, Debora Guerini de Souza, João Batista Teixeira da Rocha   +17 more
wiley   +1 more source

Genomic Ancestry, CYP2D6, CYP2C9, and CYP2C19 Among Latin Americans

Clinical pharmacology and therapy, 2019
We present the distribution of CYP2D6, CYP2C9, and CYP2C19 variants and predicted phenotypes in 33 native and admixed populations from Ibero‐America (n > 6,000) in the context of genetic ancestry (n = 3,387).
F. Rodrigues-Soares, E. Peñas-Lledó, E. Tarazona-Santos, M. Sosa-Macías, E. Terán, M. López-López, I. Rodeiro, Graciela Moya, L. R. Calzadilla, R. Ramírez-Roa, M. Grazina, F. Estévez-Carrizo, R. Barrantes, A. Llerena   +13 more
semanticscholar   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Prediction of Drug-Drug Interactions with Bupropion and Its Metabolites as CYP2D6 Inhibitors Using a Physiologically-Based Pharmacokinetic Model

Pharmaceutics, 2017
The potential of inhibitory metabolites of perpetrator drugs to contribute to drug-drug interactions (DDIs) is uncommon and underestimated. However, the occurrence of unexpected DDI suggests the potential contribution of metabolites to the observed DDI ...
Cai-fu Xue, Xunjie Zhang, Weimin Cai
semanticscholar   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

CYP2D6 polymorphisms influence the efficacy of adjuvant tamoxifen in Thai breast cancer patients

, 2012
Ekaphop Sirachainan,1 Sureerat Jaruhathai,1 Narumol Trachu,2 Ravat Panvichian,1 Thitiya Sirisinha,1 Touch Ativitavas,1 Vorachai Ratanatharathorn,1 Montri Chamnanphon,3 Chonlaphat Sukasem31Division of Medical Oncology, Department of Medicine, 2Research ...
Ativitavas T, Panvichian R, Sirachainan E, Trachu N, Ratanatharathorn V, Chamnanphon M, Sukasem C, Sirisinha T, Jaruhathai S   +8 more
core  

Cytochrome P450 CYP2D6

, 1999
Altered expression of CYP2D6 (debrisoquine hydroxylase), resulting from genetic polymorphism at the CYP2D6 gene locus, is responsible for pronounced interindividual variation in the metabolism of many clinically important drugs.
Wolf, C R, Smith, G; id_orcid
core   +2 more sources

Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2C19 and CYP2D6 and SSRIs

European Journal of Human Genetics, 2021
J. Brouwer, M. Nijenhuis, Bianca Soree, H. Guchelaar, J. Swen, R. V. van Schaik, J. van der Weide, G. Rongen, Anne M. Buunk, Nienke J. de Boer-Veger, E. Houwink, R. van Westrhenen, B. Wilffert, V. Deneer, H. Mulder   +14 more
semanticscholar   +1 more source

The CYP2D6 VCF Translator [PDF]

The Pharmacogenomics Journal, 2016
W, Qiao, J, Wang, B S, Pullman, R, Chen, Y, Yang, S A, Scott   +5 more
openaire   +2 more sources