Results 131 to 140 of about 32,925 (256)

CYP2D6 increases toxicity of the designer drug 4-methylthioamphetamine (4-MTA)

, 2007
4-Methylthioamphetamine (4-MTA) belongs to a group of new amphetamine derivatives that is usually sold as "ecstasy" or "flatliners" on the illicit drug market.
Oesch, F., Carvalho, F., Carmo, H., Remiao, F., de Boer, D., Brulport, M., Krebsfaenger, N., Hengstler, J.G., Doehmer, J., Hermes, M., Schon, M.R., Bastos Mde, L.   +11 more
core   +1 more source

DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ASSAY OF SUBSTRATES-MARKERS OF MAIN CYTOCHROME P450 ISOFORMS AND THEIR METABOLITES USING HPLC-MS/MS

Разработка и регистрация лекарственных средств, 2019
Simultaneous quantification method of assaying main CYP isoforms substrates-markers and their metabolites in urine using HPLC-MS/MS was developed to determine activity of following isoforms: caffeine/paraxanthine for CYP1A2, losartane/E-3174 for CYP2C9 ...
E. A. Egorenkov, V. V. Smirnov
doaj  

Distribution of CYP2D6 multiplication, CYP2D6*5, and clinical implications in postoperative patients receiving tramadol analgesia in the Minangkabau ethnic group, Indonesia [version 3; peer review: 2 approved]

F1000Research
Background Cytochrome P450 2D6 (CYP2D6) is an important enzyme that metabolizes commonly used drugs, such as tramadol hydrochloride. Genetic polymorphisms of CYP2D6 have been shown to influence the pharmacodynamic properties of administered drugs.
Nuruliawaty Utami, Bagus Dermawan, Asrul Muhammad Fuad, Aufa Rizqia Haz, Rinal Effendi, . Desriani   +5 more
doaj   +1 more source

The Boron–Neuron Connection: The Potential of Boron‐Containing Molecules for Treating Incurable Amyotrophic Lateral Sclerosis

ChemMedChem, Volume 21, Issue 21, 12 November 2026.
Can a single element help address the multifactorial nature of ALS? Boron‐containing compounds combine responsiveness to reactive oxygen species (ROS), neuroprotective activity, and favorable pharmacological properties, offering a distinctive framework for disease modification in a complex disease like ALS.
Nitesh Sanghai, Billy Vuong, Muhammad Shaharyar K. Afridi, Sasha Leggett, Hemin Roghzai, Geoffrey K. Tranmer   +5 more
wiley   +1 more source

Genotypes for the cytochrome P450 enzymes CYP2D6 and CYP2C19 in human longevitY: Role of CYP2D6 and CYP2C19 in longevity

, 1998
Udgivelsesdato: 1998-JulOBJECTIVE: To test whether some genotypes for CYP2D6 or CYP2C19 could contribute to longevity, we genotyped 241 Danish nonagenarians and centenarians for CYP2D6 and CYP2C19.
Brøsen, K, Boldsen, J, Bathum, L, Andersen-Ranberg, K; id_orcid, Jeune, B   +4 more
core   +1 more source

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, Volume 78, Issue 11, Page 1618-1630, November 2026.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3716-3732, November 2026.
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba, Mishael Ssesanga, Munir Pirmohamed   +2 more
wiley   +1 more source

Concentrations of tamoxifen and its metabolites (means (±SD), medians (in cursive) and ranges (in parentheses)) detected in patients with the CYP2D6, CYP3A4 and CYP3A5 genotypes.

, 2013
(+)For the CYP2D6 genotypes:“wt” includes all extensive metabolizer alleles (CYP2D6*1, CYP2D6*2, CYP2D6*35).“wtxN” includes all ultraextensive metabolizer alleles (CYP2D6*1xN, CYP2D6*2xN).“P” includes all null alleles (CYP2D6*3, CYP2D6*4, CYP2D6*5 ...
María Gaibar (438767), Armando Tejerina (69982), Luis Miguel Chicharro (438771), Fernando Bandrés (341079), Apolonia Novillo (438768), Ana Fernández-Santander (438766), Alicia Romero-Lorca (438769), Margarita Rubio (438770)   +7 more
core   +1 more source

Sedative Potential of L (+)‐Tartaric Acid: Behavioral Evidence With In Silico Insights Into Possible GABAergic Interaction

Brain and Behavior, Volume 16, Issue 11, November 2026.
ABSTRACT Purpose Insomnia is a prevalent neurological disorder often caused by stress, anxiety, and imbalances in the GABAergic system. Although benzodiazepines like diazepam (DZP) are commonly prescribed, their long‐term use is associated with adverse effects, including dependence and impaired coordination.
Sumaya Akter Bithi, Anike Chakrabarty, Khadija Akter, Chinmoy Kumar Saha, Mohammad Y. Alshahrani, Md. Arif Hossain, Emon Mia, Noshin Tasnim Yana, Afiya Ajmee, Proma Mandal, Md. Sakib Al Hasan, Muhammad Torequl Islam   +11 more
wiley   +1 more source

Solanidine is a sensitive and specific dietary biomarker for CYP2D6 activity

Human Genomics
Background Individual assessment of CYP enzyme activities can be challenging. Recently, the potato alkaloid solanidine was suggested as a biomarker for CYP2D6 activity.
Johanna I. Kiiski, Mikko Neuvonen, Mika Kurkela, Päivi Hirvensalo, Kreetta Hämäläinen, E. Katriina Tarkiainen, Johanna Sistonen, Mari Korhonen, Sofia Khan, Arto Orpana, Anne M. Filppula, Marko Lehtonen, Mikko Niemi   +12 more
doaj   +1 more source