Results 171 to 180 of about 2,707,171 (199)

Genotype and Allele Frequencies of Polymorphic CYP2E1 in the Turkish Population

Archives of Toxicology, 2007
Cytochrome P4502E1 (CYP2E1) gene shows genetic polymorphisms that vary markedly in frequency among different ethnic and racial groups. We studied the genotype distributions and allele frequencies of three CYP2E1 polymorphisms: CYP2E1*5B (RsaI/PstI RFLP ...
Emel Arinc
exaly   +2 more sources

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Functional Polymorphism in Porcine CYP2E1 Gene: Its Association With Skatole Levels

Journal of Steroid Biochemistry and Molecular Biology, 2006
Raising intact male pigs would have a significant economic impact on the pork industry. However, the presence of skatole (a major cause of boar taint) in meat from intact male pigs could be highly objectionable to consumer. The excessive accumulation of skatole in fat is a major cause of boar taint, and is associated with defective expression of ...
E James Squires
exaly   +3 more sources

Detection and characterization of novel polymorphisms in the CYP2E1 gene

Pharmacogenetics, 1998
To investigate whether interindividual variation in CYP2E1 levels can be explained by genetic polymorphism, we analysed DNA samples from 40 healthy individuals by single-strand conformational polymorphism analysis for polymorphisms in the CYP2E1 coding sequence and promoter region.
K S, Fairbrother, J, Grove, I, de Waziers, D T, Steimel, C P, Day, C L, Crespi, A K, Daly   +6 more
openaire   +2 more sources

Hypomethylation and Hypoexpression of Human CYP2E1 Gene in Lung Tumors

Biochemical and Biophysical Research Communications, 1994
We have demonstrated the presence of CYP2E1 protein in a catalytically active form in lung tumors, differences being observed between the tumors and normal tissues from the same patients. Indeed, a higher microsomal CYP2E1 N-nitrosodimethylamine (NDMA) demethylase activity was present in normal tissues compared to tumors and was accompanied by ...
F, Botto, E, Seree, S, el Khyari, P, Cau, A, Henric, M, De Meo, P, Bergeron, Y, Barra   +7 more
openaire   +2 more sources

CYP2E1 gene polymorphism and ovarian cancer risk in the Yakut population

Russian Journal of Genetics, 2011
The CYP2E1 gene polymorphism has been studied in Yakut women with ovarian cancer and without cancer. The two groups have been found to substantially differ in the frequency of the CYP2E1* 1D allele (with a 96-bp insertion in the promoter region of the gene): it is more frequent in healthy women (16.3 versus 7.4%, P = 0.007).
A V, Khrunin, F G, Ivanova, A A, Moiseev, V A, Gorbunova, S A, Limborskaia   +4 more
openaire   +2 more sources

Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease

Clinica Chimica Acta, 2007
Detoxification genes are potential candidates in the susceptibility of patients with chronic obstructive pulmonary disease. Polymorphisms in these genes alter the metabolism of xenobiotics such as present in cigarette smoke.We conducted a case-control study to investigate total 9 polymorphisms of CYP2E1, CYP2D6 and NAT2 genes by PCR-RFLP.The -1053C/T ...
Ehtesham, Arif, Arpana, Vibhuti, Pervez, Alam, Desh, Deepak, Bhawani, Singh, Mohammad, Athar, M A Qadar, Pasha   +6 more
openaire   +2 more sources

Polymorphism of the 5′-Flanking Region of the CYP2E1 Gene: An Association Study With Alcoholism

Alcoholism: Clinical and Experimental Research, 2001
Background: Recently, a restriction fragment length polymorphism in the regulatory region of the CYP2E1 gene was identified. It has been suggested that the polymorphism is associated with the elevated activity of the cytochrome P‐450 2E1 (CYP2E1) enzyme in obese or alcoholic subjects.
Sakae Itoga, Shoji Harada
exaly   +3 more sources

Polymorphism in CYP1A1 and CYP2E1 genes and susceptibility to leukoplakia in Indian tobacco users

Cancer Letters, 2003
Inter-individual genetic differences may contribute to differences in susceptibility to human diseases triggered by environmental exposures. In this study, we investigated polymorphisms at two sites in the CYP1A1 and three sites in the CYP2E1 genes in 99 leukoplakia patients and 227 controls from one Indian population.
Nilabja, Sikdar, Sk Abdul, Mahmud, Ranjan Rashmi, Paul, Bidyut, Roy   +3 more
openaire   +2 more sources

CYP2E1 Impairs GLUT4 Gene Expression and Function: NRF2 as a Possible Mediator

Hormone and Metabolic Research, 2014
Impaired GLUT4 function/expression in insulin target tissues is well-documented in diabetes and obesity. Cytochrome P450 isoform 2E1 (CYP2E1) induces oxidative stress, leading to impaired insulin action. CYP2E1 knockout mice are protected against high fat diet-induced insulin resistance and obesity; however the molecular mechanisms are still unclear ...
M, Armoni, C, Harel, M, Ramdas, E, Karnieli   +3 more
openaire   +2 more sources

Gene copy number variation analysis reveals dosage-insensitive expression of CYP2E1

The Pharmacogenomics Journal, 2015
Gene copy number variants (CNVs) of CYP2E1 have been described but not functionally characterized. Here we investigated effects of CNVs on hepatic and lymphoblastoid CYP2E1 expression. Using available single-nuleotide polymorphism microarray data and quantitative PCR, CYP2E1 gene duplication and deletion carriers were identified.
R Tremmel, K Klein, S Winter, E Schaeffeler, U M Zanger   +4 more
openaire   +2 more sources