Results 71 to 80 of about 25,509 (198)

In Vivo Toxicity of Solasonine and Its Effects on cyp450 Family Gene Expression in the Livers of Male Mice from Four Strains

Toxins, 2018
Solasonine was reported to inhibit tumour cell growth in several different models. The in vivo toxicity of solasonine, the effects of genetic background on its toxicity, and its possible roles in regulating the expression of cyp450 family genes were ...
Youbao Zhong, Shanshan Li, Liling Chen, Zhiyong Liu, Xiaoquan Luo, Peng Xu, Lai Chen   +6 more
doaj   +1 more source

Regulation of High-Altitude Hypoxia on the Transcription of CYP450 and UGT1A1 Mediated by PXR and CAR

Frontiers in Pharmacology, 2020
Little is known about what roles the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) play in drug metabolism in high-altitude hypoxia.
Ya-bin Duan, Ya-bin Duan, Jun-bo Zhu, Jun-bo Zhu, Jian-xin Yang, Gui-qin Liu, Xue Bai, Ning Qu, Xue-jun Wang, Xiang-yang Li   +9 more
doaj   +1 more source

Neurological Adverse Effects Associated With Commonly Used H1‐Antihistamines: A Narrative Review of Age‐Stratified Risk Profiles in Paediatric and Geriatric Populations

Medicine Advances, EarlyView.
This narrative review examines the neurological adverse effects associated with commonly used H1‐antihistamines, focusing on how blood–brain barrier (BBB) penetration and patient age influence central nervous system (CNS) toxicity. The major finding is that first‐generation antihistamines, because of higher CNS penetration, are associated with ...
Syeda Samia Fatima, Zahabia Adnan, Rabia Nizam, Marium Fawad, Zainab Mehmood, Areeba Asif, Ali Aamir   +6 more
wiley   +1 more source

Current status and future perspectives of platelet function‐guided precision antiplatelet therapy for patients with cerebral infarction

Neuroprotection, EarlyView.
Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu, Xiaoling Chen, Xinyi Huang, Quandan Tan, Qing Cao, Yali Yang, Yapeng Lin, Jie Yang   +7 more
wiley   +1 more source

Verapamil does not modify catalytic activity of CYP450 in rainbow trout after long-term exposure

, 2012
Little is known about the effects of the cardiovascular drug verapamil (VRP) on metabolic processes in fish. Most calcium channel blockers including VRP are metabolized by cytochrome P450 (CYP450) enzymes. In this study we investigated the in vivo effect
Sveriges lantbruksuniversitet., Zamaratskaia, Galia,, Zlabek, Vladimir,, Pickova, Jana,, Zlabek, Vladimir, Li, Z.H., Fedorova, Ganna, Randak, T., Burkina, Viktoriia   +8 more
core   +1 more source

Spotlight commentary: Drug therapy in hypoxic environments: From aerospace models to high‐altitude clinical pharmacology

British Journal of Clinical Pharmacology, EarlyView.
Martin Bobek, Jakov Kožić, Feđa Džubur   +2 more
wiley   +1 more source

Applications of nanocarrier‐delivered RNA interference in agricultural biological control (2009–2025)

New Plant Protection, EarlyView.
Despite 17 years of development, the effectiveness of nanocarrier‐delivered RNAi pesticide (NDRP) for agricultural biological control remains limited. The successful development of effective NDRP development requires the coordinated optimization of target gene selection and nanocarrier properties, including RNA dosage, multi‐gene targeting, protection ...
Shi Dong Wang, Woo‐Jong Hong, Xu Jiang, Ki‐hong Jung, Yuan Hu Xuan   +4 more
wiley   +1 more source

Venn diagram showing the numbers of CYP450 genes expressed across the three tissues.

, 2014
Venn diagram showing the numbers of CYP450 genes expressed across the three tissues.
Kai Wu (221862), David R. Nelson (43435), Bin Wu (138543), Chang Liu (35901), Haimei Chen (392203)   +4 more
core   +1 more source

Cytochrome P450 Gene Polymorphisms and Their Influence on Antipsychotic Pharmacokinetics in Schizophrenia: A Review

Безопасность и риск фармакотерапии
INTRODUCTION. The activity of cytochrome P450 enzymes (CYP450), which play a key role in antipsychotic metabolism, influences treatment efficacy and safety.
M. O. Zhukova, N. M. Kiseleva
doaj   +1 more source

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source