Results 111 to 120 of about 22,923 (293)

Cypher - An Operating System

International Journal of Scientific Research in Engineering and Management
Abstract - Minimal Linux-based operating systems provide a practical environment for examining how user-space components interact with the kernel, but mainstream operating systems often obscure these fundamentals behind complex subsystems. Custom shells offer a clearer view of command interpretation by exposing the fundamental stages without inherited ...
Manoj S, Prof. Ashwini R, Venkateshwaran S, Yashwanth Rao H, Sanjay G K   +4 more
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Proving Cypher Query Equivalence

2025 IEEE 41st International Conference on Data Engineering (ICDE)
Graph database systems store graph data as nodes and relationships, and utilize graph query languages (e.g., Cypher) for efficiently querying graph data. Proving the equivalence of graph queries is an important foundation for optimizing graph query performance, ensuring graph query reliability, etc.
Tang, Lei, Dou, Wensheng, Zheng, Yingying, Xu, Lijie, Wang, Wei, Wei, Jun, Huang, Tao   +6 more
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Triángulo del neo-desarrollismo en Ecuador

Problemas del Desarrollo, 2016
La tesis neo-desarrollista se centra básicamente en un proceso de transformación socioeconómica endógena, liderado por políticas públicas. Para lograr tales fines se requieren tres estrategias conjuntas: i) fomento de un proyecto nacional; ii ...
James M. Cypher, Yolanda Alfaro
doaj  

Comparación entre Bases de Datos Orientadas a Grafo y Relacional basado en el rendimiento

Serie Científica de la Universidad de las Ciencias Informáticas, 2020
Actualmente en cada segundo y minuto en el mundo son generados grandes cantidades de datos que necesitan ser almacenados y procesados, esta información es muy variada en cuanto a la forma de almacenamiento y fuente de procedencia así como son muchos y ...
Royland Rodriguez Reyes
doaj  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Domain- and Language-Adaptable Natural Language Interface for Property Graphs

Computers
Despite the growing adoption of Property Graph Databases, like Neo4j, interacting with them remains difficult for non-technical users due to the reliance on formal query languages.
Ioannis Tsampos, Emmanouil Marakakis
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source