Results 161 to 170 of about 7,096 (220)
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International Journal of Peptide and Protein Research, 1986
A cystamine‐enkephalin dimer, containing two molecules of [D‐Ala2, Leu5] enkephalin cross‐linked at theCOOH‐terminal leucine residue with cystamine, (NH2‐CH2‐CH2‐S‐)2, has been synthesized in order to examine directly the dimerization effect of an enkephalin molecule on the opiate receptor interactions. In a comparison of potencies against [3H]‐[D‐Ala2,
MICHIO KONDO +3 more
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A cystamine‐enkephalin dimer, containing two molecules of [D‐Ala2, Leu5] enkephalin cross‐linked at theCOOH‐terminal leucine residue with cystamine, (NH2‐CH2‐CH2‐S‐)2, has been synthesized in order to examine directly the dimerization effect of an enkephalin molecule on the opiate receptor interactions. In a comparison of potencies against [3H]‐[D‐Ala2,
MICHIO KONDO +3 more
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1987
Publisher Summary This chapter discusses about cysteamine and cystamine. Cysteamine (2-aminoethanethiol) is formed in mammalian tissues by the enzymatic hydrolysis of pantetheine, and has the role in the biosynthesis of hypotaurine. Cysteamine has been used therapeutically to treat cystinosis and sickle cell anemia, and has been used as a protective ...
M W, Duffel, D J, Logan, D M, Ziegler
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Publisher Summary This chapter discusses about cysteamine and cystamine. Cysteamine (2-aminoethanethiol) is formed in mammalian tissues by the enzymatic hydrolysis of pantetheine, and has the role in the biosynthesis of hypotaurine. Cysteamine has been used therapeutically to treat cystinosis and sickle cell anemia, and has been used as a protective ...
M W, Duffel, D J, Logan, D M, Ziegler
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Cystamine modulation of galactosamine-induced hepatotoxicity
Toxicology and Applied Pharmacology, 1984The ability of cystamine treatment to protect against galactosamine-induced hepatic necrosis was investigated. Reduced hepatotoxicity was observed following galactosamine hydrochloride (400 mg/kg, ip) in male Sprague-Dawley rats that received cystamine dihydrochloride (300 mg/kg, po) 30 min prior to or 2, 4, 6, 8, or 12 hr after galactosamine.
J R, MacDonald +2 more
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Interaction of Cystamine and Cystamine Derivatives with Nucleic Acids and Nucleoproteins
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1965SummaryThe disulphides–cystamine, bis (2-guanidoethyl) disulphide (GED), dimethylcystamine, tetramethylcystamine, tetraethyl cystamine, cystine dimethyl ester and cystine diethyl ester–have been shown to interact with and become reversibly bound to calf thymus DNA, E. ccli RNA, and to calf-thymus and rat-liver nucleoproteins.
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Bioconjugate Chemistry, 1998
Pneumococcal polysaccharide type 6B, 14, or 23F (35-70 kDa) was activated with cyanogen bromide and modified with cystamine. After reduction of the spacer, the thiol-containing (i.e. cysteamine-modified) polysaccharide obtained was added in a 5-10-fold molar excess to bromoacetylated tetanus toxoid to give thioether-linked polysaccharide-protein ...
de Weers, O +5 more
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Pneumococcal polysaccharide type 6B, 14, or 23F (35-70 kDa) was activated with cyanogen bromide and modified with cystamine. After reduction of the spacer, the thiol-containing (i.e. cysteamine-modified) polysaccharide obtained was added in a 5-10-fold molar excess to bromoacetylated tetanus toxoid to give thioether-linked polysaccharide-protein ...
de Weers, O +5 more
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The ability of cystamine to bind DNA
Amino Acids, 2002The DNA-binding properties of cystamine compared with natural occurring polyamines have been studied in vitro by means of ethidium bromide displacement assays, studies of DNA thermal stability and analyses of DNA-B/DNA-A transition. While the first two methods did not put in evidence any peculiar property in the binding capability of cystamine, CD ...
ALLEGRA, Paola +3 more
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ChemInform Abstract: Synthesis of Cystamine.
ChemInform, 1991AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. D. BULAT +4 more
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A Trial of Cystamine in Radiation Sickness
The British Journal of Radiology, 1960A trial was made of the radioprotective substance, Cystamine, in radiation sickness. It did not prove more effective than lactose.
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Neuroprotective effects of cystamine in aged parkinsonian mice
Neurobiology of Aging, 2006Accumulating evidence suggests an important role of oxidation in pathologies such as Parkinson's disease. Here, we investigated the effects of cystamine, which has shown neuroprotection in animal models of Huntington's disease, in a parkinsonian mouse generated by the toxin MPTP. Aged mice (16 months of age) were assigned to either a 10 or 50 mg/kg/day
Marie-Eve, Tremblay +5 more
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The radiation chemistry of cystamine sulphate
Journal of the Chemical Society B: Physical Organic, 1967Irradiation of aqueous cystamine solutions with X-rays (230 kV; 15 mA), in the presence of oxygen, results in the formation of taurine, hydrogen peroxide, and traces of hydrogen sulphide. When oxygen is removed from the solution, hydrogen sulphide formation increases noticeably, while yields of taurine and peroxide both decrease.
G. G. Jayson +2 more
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