Results 181 to 185 of about 34,415 (185)

Decreased expression of cystathionine β-synthase exacerbates intestinal barrier injury in ulcerative colitis.

Journal of Crohn's & Colitis, 2019
Background and Aims Endogenous hydrogen sulfide (H2S) regulates multiple physiological and pathological processes in colon epithelial tissues. The current study investigated the role of cystathionine β-synthase (CBS), a major producer of H2S in colon ...
Shanwen Chen, S. Zuo, Jing Zhu, Taohua Yue, D. Bu, Xin Wang, Pengyuan Wang, Yisheng Pan, Yucun Liu   +8 more
semanticscholar   +1 more source

Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine β‐synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial

Journal of Inherited Metabolic Disease, 2019
A phase 1/2 clinical trial was performed in individuals with cystathionine β synthase (CBS) deficient homocystinuria with aims to: (a) assess pharmacokinetics and safety of taurine therapy, (b) evaluate oxidative stress, inflammation, and vascular ...
J. V. Van Hove, C. Freehauf, C. Ficicioglu, Loren D. M. Pena, K. Moreau, T. Henthorn, U. Christians, Hua Jiang, T. Cowan, S. Young, M. Hite, Marisa W Friederich, S. Stabler, E. Spector, K. Kronquist, J. Thomas, P. Emmett, M. J. Harrington, L. Pyle, Geralyn Creadon‐Swindell, M. Wempe, K. Maclean   +21 more
semanticscholar   +1 more source

Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of Drosophila melanogaster

Mechanisms of Ageing and Development, 2022
M. Shaposhnikov, A. Zakluta, N. Zemskaya, Z. Guvatova, V. Shilova, D. Yakovleva, Anastasia Gorbunova, Liubov A. Koval, N. Ulyasheva, M. Evgen'ev, O. Zatsepina, A. Moskalev   +11 more
semanticscholar   +1 more source

The role of cystathionine β-synthase in cancer.

Cellular Signalling
Yan-Wen Wang, Ti Chu, Xue-Li Wang, Yong-Qi Fan, Lei Cao, Yu-Hang Chen, Yi-Wen Zhu, Hong-Xia Liu, Xin-Ying Ji, Dong-Dong Wu   +9 more
semanticscholar   +1 more source

Attenuation of Antioxidant Capacity in Human Breast Cancer Cells by Carbon Monoxide through Inhibition of Cystathionine β-Synthase Activity: Implications in Chemotherapeutic Drug Sensitivity.

Journal of Medicinal Chemistry, 2017
Brian Kawahara, T. Moller, Kayla Hu-Moore, S. Carrington, K. Faull, S. Sen, P. Mascharak   +6 more
semanticscholar   +1 more source