Cystathionine β-synthase as novel endogenous regulator of lymphangiogenesis via modulating VEGF receptor 2 and 3 [PDF]
Communications Biology, 2022 Quantitative trait locus analysis of BALB/cN x C57BL/6 N intercross identifies cystathionine β-synthase as a previously unknown regulator of lymphangiogenesis by affecting VEGF-R2/VEGF-R3 expression in lymphatic endothelial cells.
Niloofar Hatami +7 more
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Heme-Thiolate Perturbation in Cystathionine β‑Synthase by Mercury Compounds [PDF]
ACS Omega, 2021 Cystathionine β-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.
Dayana Benchoam +5 more
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Emerging roles of cystathionine β-synthase in various forms of cancer [PDF]
Redox Biology, 2022 The expression of the reverse transsulfuration enzyme cystathionine-β-synthase (CBS) is markedly increased in many forms of cancer, including colorectal, ovarian, lung, breast and kidney, while in other cancers (liver cancer and glioma) it becomes ...
Kelly Ascenção, Csaba Szabo
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Cystathionine-β-synthase: Molecular Regulation and Pharmacological Inhibition [PDF]
Biomolecules, 2020 Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration pathway, is an important mammalian enzyme in health and disease. Its biochemical functions under physiological conditions include the metabolism of homocysteine (
Karim Zuhra +3 more
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Cystathionine β-synthase and methylenetetrahydrofolate reductase mutations in Mexican individuals with hyperhomocysteinemia [PDF]
SAGE Open Medicine, 2020 Background: Hyperhomocysteinemia, a thrombotic risk factor, may have several causes. Among the genetic causes of hyperhomocysteinemia, there are polymorphisms in the enzymes methylenetetrahydrofolate reductase (C677T) and cystathionine β-synthase (C699T,
Anahi Guadalupe Figueroa-Torres +10 more
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Role of cystathionine-β-synthase and hydrogen sulfide in down syndrome [PDF]
NeurotherapeuticsDown syndrome (DS) is a genetic condition where the person affected by it is born with an additional – full or partial – copy of chromosome 21. DS presents with characteristic morphological features and is associated with a wide range of biochemical ...
Csaba Szabo
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Cystathionine β-synthase TtCbs1 from Tetrahymena thermophila catalyzes the synthesis of CdS quantum dots for methyl orange decolorization [PDF]
Applied and Environmental MicrobiologyCystathionine β-synthase (CBS) is a pivotal enzyme in the transsulfuration metabolic pathway, catalyzing the synthesis of H2S and cystathionine. These metabolites mediate stress responses and maintain cellular redox homeostasis.
Wenliang Lei +3 more
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The Reliable Detection of Homocysteine Using a Biosensor Based on Recombinant Cystathionine β-Synthase and Nanoporous Gold [PDF]
MicroorganismsGiven the essential roles of homocysteine (Hcy) and the interference of cysteine in effectively monitoring human health, this study proposed a synergistic effect strategy that combines the unique structural and functional properties of nanoporous gold ...
Zihan Huang +5 more
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Elevated homocysteine is negatively correlated with plasma cystathionine β‐synthase activity in givosiran‐treated patients [PDF]
JIMD ReportsGivosiran is a subcutaneously administered, liver‐targeted RNA interference (RNAi) therapeutic that has been approved for treating acute hepatic porphyria (AHP).
Mark A. Keibler +3 more
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Distribution of two kinds of cystathionine γ-synthase in various bacteria [PDF]
FEMS Microbiology Letters, 1986 Abstract The substrate specificity of cystathionine γ-synthase (EC 4.2.99.9) in various bacteria was examined. O -Succinyl- l -homoserine was used preferably as a substrate by facultative anaerobic Gram-negative bacteria belonging to such genera as Escherichia, Klebsiella, Enterobacter, Citrobacter, Erwinia, Serratia, Proteus and Salmonella .
Hiroshi Kanzaki +3 more
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