Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium. [PDF]
PLoS ONE, 2015 Urothelium, the epithelial lining the inner surface of human bladder, plays a key role in bladder physiology and pathology. It responds to chemical, mechanical and thermal stimuli by releasing several factors and mediators.
Roberta d'Emmanuele di Villa Bianca +10 more
doaj +3 more sources
Blockade of the trans-sulfuration pathway in acute pancreatitis due to nitration of cystathionine β-synthase [PDF]
Redox Biology, 2020 Acute pancreatitis is an inflammatory process of the pancreatic gland that may lead to dysregulation of the trans-sulfuration pathway. The aims of this work were firstly to study the methionine cycle as well as the trans-sulfuration pathway using ...
Sergio Rius-Pérez +11 more
doaj +2 more sources
Enhanced expression of cystathionine β-synthase and cystathionine γ-lyase during acute cholecystitis-induced gallbladder inflammation. [PDF]
PLoS ONE, 2013 BACKGROUND: Hydrogen sulfide (H2S) has recently been shown to play an important role in the digestive system, but the role of endogenous H2S produced locally in the gallbladder is unknown.
Li Zhang +4 more
doaj +2 more sources
Genes & Nutrition, 2018 Background The neurodegenerative disorder Alzheimer’s disease is caused by the accumulation of toxic aggregates of β-amyloid in the human brain. On the one hand, hyperhomocysteinemia has been shown to be a risk factor for cognitive decline in Alzheimer’s
Anne Leiteritz +3 more
doaj +2 more sources
ICI 182,780 Attenuates Selective Upregulation of Uterine Artery Cystathionine β-Synthase Expression in Rat Pregnancy. [PDF]
Int J Mol Sci, 2023 Endogenous hydrogen sulfide (H2S) produced by cystathionine β-synthase (CBS) and cystathionine-γ lyase (CSE) has emerged as a novel uterine vasodilator contributing to pregnancy-associated increases in uterine blood flow, which safeguard pregnancy health.
Bai J +8 more
europepmc +2 more sources
α-Helix in Cystathionine β-Synthase Enzyme Acts as Electron Reservoir [PDF]
, 2021 The modulation of electron density at the Pyridoxal 5-phosphate (PLP) catalytic center, due to charge transfer across the α-Helix-PLP interface, is the determining factor for the enzymatic activities in the human Cystathionine β-Synthase (hCBS) enzyme ...
Aashish , Bhatt +2 more
core +1 more source
Understanding the Role of R266K Mutation in Cystathionine β-Synthase (CBS) Enzyme: An in Silico Study [PDF]
, 2021 Human cystathionine β-synthase (hCBS) is a Heme containing unique pyridoxal 5’-phosphate (PLP) dependent enzyme that catalyzes the bio-chemical condensation reactions in the transsulfuration pathway. The role of Heme in the catalytic activities of enzyme
Md. Ehesan, Ali, Aashish, Bhatt
core +1 more source
Brain phenotype of transgenic mice overexpressing cystathionine β-synthase. [PDF]
PLoS ONE, 2012 The cystathionine β-synthase (CBS) gene, located on human chromosome 21q22.3, is a good candidate for playing a role in the Down Syndrome (DS) cognitive profile: it is overexpressed in the brain of individuals with DS, and it encodes a key enzyme of ...
Vinciane Régnier +15 more
doaj +1 more source
Hypoxia-Induced Changes in L-Cysteine Metabolism and Antioxidative Processes in Melanoma Cells
Biomolecules, 2023 This study was performed on human primary (WM115) and metastatic (WM266-4) melanoma cell lines developed from the same individual. The expression of proteins involved in L-cysteine metabolism (sulfurtransferases, and cystathionine β-synthase) and ...
Leszek Rydz +3 more
doaj +1 more source
CBS promoter hypermethylation increases the risk of hypertension and stroke
Clinics, 2019 OBJECTIVES: Cystathionine β-synthase is a major enzyme in the metabolism of plasma homocysteine. Hyperhomocysteinemia is positively associated with hypertension and stroke.
Changyi Wang +12 more
doaj +1 more source