Results 31 to 40 of about 1,025,233 (163)

CYSTATHIONINE β-SYNTHASE DEFICIENCY: METABOLIC ASPECTS [PDF]

, 1997
Cystathionine β-synthase (CBS) deficiency was first demonstrated in 1964 in an eight-year-old mentally retarded girl with bilaterally dislocated optic lenses who excreted abnormally elevated amounts of homocystine in her urine.
Mudd, S. Harvey, S. Harvey Mudd
core   +1 more source

Harnessing the Benefits of Endogenous Hydrogen Sulfide to Reduce Cardiovascular Disease

Antioxidants, 2021
Cardiovascular disease is the leading cause of death in the U.S. While various studies have shown the beneficial impact of exogenous hydrogen sulfide (H2S)-releasing drugs, few have demonstrated the influence of endogenous H2S production.
Kevin M. Casin, John W. Calvert
doaj   +1 more source

IMPDH2 Is an Intracellular Target of the Cyclophilin A and Sanglifehrin A Complex

Cell Reports, 2017
Summary: Natural products have demonstrated utility in the clinic and can also act as probes to understand complex cellular pathways. Sanglifehrin A (SFA) is a mixed polyketide and non-ribosomal peptide synthase natural product with sub-nano-molar ...
Khian Hong Pua, Dylan T. Stiles, Mathew E. Sowa, Gregory L. Verdine   +3 more
doaj   +1 more source

Cystathionine β -Synthase in Physiology and Cancer [PDF]

, 2018
Cystathionine β-synthase (CBS) regulates homocysteine metabolism and contributes to hydrogen sulfide (H2S) biosynthesis through which it plays multifunctional roles in the regulation of cellular energetics, redox status, DNA methylation, and protein ...
Chan, KT, Kang, J, Pearson, Richard B., Zhu, Haoran, Blake, S, Blake, Shaun, Chan, Keefe T., Zhu, H, Pearson, RB, Kang, Jian   +9 more
core   +1 more source

Significance of Hydrogen Sulfide Production in the Pancreatic β-Cell

Journal of Pharmacological Sciences, 2011
.: Hydrogen sulfide (H2S) is an important signaling molecule in various mammalian cells and tissues. H2S is synthesized from l-cysteine and regulates several cellular and physiological phenomena (vasorelaxation, hormone secretion, and apoptosis) and ...
Shigeki Taniguchi, Ichiro Niki
doaj   +1 more source

Endogenous Hydrogen Sulfide Enhances Carotid Sinus Baroreceptor Sensitivity by Activating the Transient Receptor Potential Cation Channel Subfamily V Member 1 (TRPV1) Channel

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background We aimed to investigate the regulatory effects of hydrogen sulfide (H2S) on carotid sinus baroreceptor sensitivity and its mechanisms. Methods and Results Male Wistar‐Kyoto rats and spontaneously hypertensive rats (SHRs) were used in the ...
Wen Yu, Ying Liao, Yaqian Huang, Selena Y. Chen, Yan Sun, Chufan Sun, Yuming Wu, Chaoshu Tang, Junbao Du, Hongfang Jin   +9 more
doaj   +1 more source

Expression of cystathionine beta-synthase and histopathological observations in placentas of patients with down syndrome

, 2015
Down syndrome is the most frequent aneuploidy in live births, with an overall frequency of 1/600-700 births. The overexpression of cystathionine β-synthase is thought to participate in the presentation of some phenotypes observed in Down syndrome ...
Olaya-C, M., J. Martínez, Pinilla, García-Robles, R., Ayala-Ramírez, P., Bermúdez, M.   +4 more
core   +2 more sources

A genome wide association scan for (1,3;1,4)-β-glucan content in the grain of contemporary 2-row Spring and Winter barleys [PDF]

, 2014
Background: (1,3;1,4)-β-Glucan is an important component of the cell walls of barley grain as it affects processability during the production of alcoholic beverages and has significant human health benefits when consumed aboverecommended threshold levels.
Russell, J., Oakey, H., Neil Shirley, Jennifer M Washington, Schreiber, Miriam, Booth, A., Joanne Russell, Russell, Joanne, Houston, Kelly, Houston, K., Fincher, G., Booth, Allan, Helena Oakey, Schreiber, M., Shirley, Neil, Shirley, N., Washington, Jennifer M., Rachel A Burton, Halpin, C., Burton, Rachel A., Waugh, R., Miriam Schreiber, Halpin, Claire, Robbie Waugh, Oakey, Helena, Fincher, Geoffrey B., Washington, J., Kelly Houston, Geoffrey B Fincher, Allan Booth, Waugh, Robbie; id_orcid, Burton, R., Claire Halpin   +32 more
core   +1 more source

Allosteric regulation accompanied by oligomeric state changes of Trypanosoma brucei GMP reductase through cystathionine-β-synthase domain

Nature Communications, 2020
Trypanosoma brucei guanosine 5′-monophosphate reductase (TbGMPR) catalyses the conversion of GMP to inosine 5′-monophosphate and contains a cystathionine-β-synthase (CBS) domain. Here the authors combine X-ray crystallography and kinetic measurements and
Akira Imamura, Tetsuya Okada, Hikaru Mase, Takuya Otani, Tomoka Kobayashi, Manatsu Tamura, Bruno Kilunga Kubata, Katsuaki Inoue, Robert P. Rambo, Susumu Uchiyama, Kentaro Ishii, Shigenori Nishimura, Takashi Inui   +12 more
doaj   +1 more source

Cystathionine β-Synthase Is Necessary for Axis Development in Vivo

Frontiers in Cell and Developmental Biology, 2018
The cystathionine ß-synthase (CBS) is a critical enzyme in the transsulfuration pathway and is responsible for the synthesis of cystathionine from serine and homocysteine. Cystathionine is a precursor to amino acid cysteine.
Shubhangi Prabhudesai, Chris Koceja, Anindya Dey, Shahram Eisa-Beygi, Noah R. Leigh, Resham Bhattacharya, Resham Bhattacharya, Priyabrata Mukherjee, Priyabrata Mukherjee, Priyabrata Mukherjee, Priyabrata Mukherjee, Ramani Ramchandran, Ramani Ramchandran, Ramani Ramchandran   +13 more
doaj   +1 more source