Cystathionine gamma lyase aggravates orthodontic root resorption in mice. [PDF]
Ann Transl Med, 2019 This study aimed to determine the contribution of cystathionine gamma lyase (CSE) to physiological and orthodontic root resorption in mice.Mice genetically deficient in the CSE (CSE-/-), the dominant hydrogen sulfide (H2S)-generating enzyme in osteoclast were used in this study.
Lu C, Chen L, Hua Y.
europepmc +4 more sources
Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease
Antioxidants, 2023 3-mercaptopyruvate sulfurtransferase (3-MST) plays the important role of producing hydrogen sulfide. Conserved from bacteria to Mammalia, this enzyme is localized in mitochondria as well as the cytoplasm. 3-MST mediates the reaction of 3-mercaptopyruvate
Swetha Pavani Rao +3 more
doaj +1 more source
Cystathionine gamma lyase and hydrogen sulfide: new players in orthodontic root resorption. [PDF]
Ann Transl Med, 2020 Holliday LS, Dolce C.
europepmc +3 more sources
Decreased Gluconeogenesis in the Absence of Cystathionine Gamma-Lyase and the Underlying Mechanisms. [PDF]
Antioxid Redox Signal, 2016 Aims: To investigate the regulation of hepatic glucose production by cystathionine γ-lyase (CSE)-generated hydrogen sulfide (H 2 S) in hepatic glucose production under physiological conditions.
Untereiner AA, Wang R, Ju Y, Wu L.
europepmc +4 more sources
Endogenous Hydrogen Sulfide Is an Important Factor in Maintaining Arterial Oxygen Saturation
Frontiers in Pharmacology, 2021 The gasotransmitter H2S is involved in various physiological and pathophysiological processes. The aim of this study was to investigate the physiological functions of H2S in the lungs.
Yan Huang +11 more
doaj +1 more source
Cystathionine-gamma-lyase overexpression in T cells enhances antitumor effect independently of cysteine autonomy. [PDF]
Cancer Sci, 2021 AbstractT cells could be engineered to overcome the aberrant metabolic milieu of solid tumors and tip the balance in favor of a long‐lasting clinical response. Here, we explored the therapeutic potential of stably overexpressing cystathionine‐gamma‐lyase (CTH, CSE, or cystathionase), a pivotal enzyme of the transsulfuration pathway, in antitumor CD8+ T
Lancien M +13 more
europepmc +7 more sources
Cystathionine-Gamma-Lyase-Derived Hydrogen Sulfide-Regulated Substance P Modulates Liver Sieve Fenestrations in Caecal Ligation and Puncture-Induced Sepsis [PDF]
International Journal of Molecular Sciences, 2019 Madhav Bhatia +2 more
exaly +2 more sources
The Role of Hydrogen Sulfide in Plaque Stability
Antioxidants, 2022 Atherosclerosis is the greatest contributor to cardiovascular events and is involved in the majority of deaths worldwide. Plaque rapture or erosion precipitates life-threatening thrombi, resulting in the obstruction blood flow to the heart (acute ...
Qian Lin, Bin Geng
doaj +1 more source
Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells [PDF]
Cardiovascular Research, 2010 Cystathionine gamma-lyase (CSE)-derived H2S plays an important role in regulating cell growth. Lack of CSE expression results in development of hypertension. The current study compared proliferation of smooth muscle cells derived from CSE gene knockout mice (SMCs-KO) with that of wild-type mice (SMCs-WT).Cell proliferation was assessed by ...
Guangdong, Yang +5 more
openaire +2 more sources
The expression of cystathionine gamma-lyase is regulated by estrogen receptor alpha in human osteoblasts. [PDF]
Oncotarget, 2017 Hydrogen sulfide (H2S), generated in the osteoblasts predominantly via cystathionine-γ-lyase (CSE), is bone protective. Previous studies suggested that the onset of bone loss due to estrogen deficiency is associated to decreased levels of H2S and blunted gene expression of CSE. However, there are still a lot of unknowns on how H2S levels influence bone
Lambertini E +8 more
europepmc +4 more sources