Results 1 to 10 of about 36,958 (126)

Inhibition of fungal pathogenicity by targeting the H₂S-synthesizing enzyme cystathionine β-synthase. [PDF]

Sci Adv, 2022
The global emergence of antifungal resistance threatens the limited arsenal of available treatments and emphasizes the urgent need for alternative antifungal agents.
Chang W, Zhang M, Jin X, Zhang H, Zheng H, Zheng S, Qiao Y, Yu H, Sun B, Hou X, Lou H.   +10 more
europepmc   +2 more sources

Role of Cystathionine β-Synthase and 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics of Murine Breast Cancer Cells. [PDF]

Antioxidants (Basel), 2023
Cystathionine β-synthase (CBS), CSE (cystathionine γ-lyase) and 3-mercaptopyruvate sulfurtransferase (3-MST) have emerged as three significant sources of hydrogen sulfide (H2S) in various forms of mammalian cancer.
Santos SS, Rodrigues LOCP, Martins V, Petrosino M, Zuhra K, Ascenção K, Anand A, Abdel-Kader RM, Gad MZ, Bourquin C, Szabo C.   +10 more
europepmc   +2 more sources

Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation. [PDF]

Elife, 2022
Hyperactivation of oncogenic pathways downstream of RAS and PI3K/AKT in normal cells induces a senescence-like phenotype that acts as a tumor-suppressive mechanism that must be overcome during transformation.
Zhu H, Chan KT, Huang X, Cerra C, Blake S, Trigos AS, Anderson D, Creek DJ, De Souza DP, Wang X, Fu C, Jana M, Sanij E, Pearson RB, Kang J.   +14 more
europepmc   +2 more sources

Cystathionine β-synthase is required for oocyte quality by ensuring proper meiotic spindle assembly. [PDF]

Cell Prolif, 2022
Poor oocyte quality is detrimental to fertilization and embryo development, which causes infertility. Cystathionine β‐synthase (CBS) is one of the key enzymes modulating the metabolism of homocysteine (Hcy). Studies have shown that CBS plays an important
Cao Y, Zhu X, Zhen P, Tian Y, Ji D, Xue K, Yan W, Chai J, Liu H, Wang W.   +9 more
europepmc   +2 more sources

Cystathionine β-synthase as novel endogenous regulator of lymphangiogenesis via modulating VEGF receptor 2 and 3. [PDF]

Commun Biol, 2022
Lymphangiogenesis is a key player in several diseases such as tumor metastasis, obesity, and graft rejection. Endogenous regulation of lymphangiogenesis is only partly understood.
Hatami N, Büttner C, Bock F, Simfors S, Musial G, Reis A, Cursiefen C, Clahsen T.   +7 more
europepmc   +2 more sources

Cystathionine-β-Synthase: Molecular Regulation and Pharmacological Inhibition. [PDF]

Biomolecules, 2020
Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration pathway, is an important mammalian enzyme in health and disease. Its biochemical functions under physiological conditions include the metabolism of homocysteine (
Zuhra K, Augsburger F, Majtan T, Szabo C.   +3 more
europepmc   +2 more sources

<i>S</i>-Adenosylmethionine-responsive cystathionine β-synthase modulates sulfur metabolism and redox balance in <i>Mycobacterium</i> <i>tuberculosis</i>. [PDF]

Sci Adv, 2022
Methionine and cysteine metabolisms are important for the survival and pathogenesis of Mycobacterium tuberculosis (Mtb). The transsulfuration pathway converts methionine to cysteine and represents an important link between antioxidant and methylation ...
Bandyopadhyay P, Pramanick I, Biswas R, Ps S, Sreedharan S, Singh S, Rajmani RS, Laxman S, Dutta S, Singh A.   +9 more
europepmc   +2 more sources

Cystathionine β-synthase mediated PRRX2/IL-6/STAT3 inactivation suppresses Tregs infiltration and induces apoptosis to inhibit HCC carcinogenesis. [PDF]

J Immunother Cancer, 2021
Background Hepatocellular carcinoma (HCC) is characterized by inflammation and immunopathogenesis. Accumulating evidence has shown that the cystathionine β-synthase/hydrogen sulfide (CBS/H2S) axis is involved in the regulation of inflammation.
Zhou YF, Song SS, Tian MX, Tang Z, Wang H, Fang Y, Qu WF, Jiang XF, Tao CY, Huang R, Zhou PY, Zhu SG, Zhou J, Fan J, Liu WR, Shi YH.   +15 more
europepmc   +2 more sources

Inhibition of cystathionine β-synthase promotes apoptosis and reduces cell proliferation in chronic myeloid leukemia. [PDF]

Signal Transduct Target Ther, 2021
Increased endogenous hydrogen sulfide (H 2 S) level by cystathionine β-synthase (CBS) has been shown to closely relate tumorigenesis. H 2 S promotes angiogenesis, stimulates bioenergy metabolism and inhibits selective phosphatases.
Wang D, Yang H, Zhang Y, Hu R, Hu D, Wang Q, Liu Y, Liu M, Meng Z, Zhou W, Song W.   +10 more
europepmc   +2 more sources

Down-Regulated Expression of Cystathionine β-Synthase and Cystathionine γ-Lyase in Varicocele, and Infertile Men: A Case-Control Study. [PDF]

Cell J, 2022
Objective Cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) are two important enzymes involved in One-Carbon metabolism. These enzymes play important roles in modulating oxidative stress and inflammation in male factor infertility through ...
Akbarian F, Tavalaee M, Dattilio M, Nasr-Esfahani MH.   +3 more
europepmc   +2 more sources