Results 11 to 20 of about 36,977 (144)

Long-term functional correction of cystathionine β-synthase deficiency in mice by adeno-associated viral gene therapy. [PDF]

J Inherit Metab Dis, 2021
Cystathionine β‐synthase (CBS) deficiency is a recessive inborn error of sulfur metabolism characterized by elevated blood levels of total homocysteine (tHcy).
Lee HO, Salami CO, Sondhi D, Kaminsky SM, Crystal RG, Kruger WD.   +5 more
europepmc   +2 more sources

Cystathionine β-Synthase Regulates the Proliferation, Migration, and Invasion of Thyroid Carcinoma Cells. [PDF]

Oxid Med Cell Longev, 2022
Thyroid cancer is considered to be one of the most common endocrine tumors worldwide. Cystathionine β‐synthase (CBS) plays a crucial role in the occurrence of several types of malignancies. And yet, the mechanism of action of CBS in the growth of thyroid
Jiang QY, Li JM, Jing MR, Zhang YX, Zhang QQ, Cai CB, Wang D, Qi HW, Li T, Li YZ, Ji XY, Wu DD.   +11 more
europepmc   +2 more sources

A role for the cystathionine-β-synthase /H₂S axis in astrocyte dysfunction in the aging brain. [PDF]

Redox Biol, 2023
Dey A, Pramanik PK, Dwivedi SKD, Neizer-Ashun F, Kiss T, Ganguly A, Rice H, Mukherjee P, Xu C, Ahmad M, Csiszar A, Bhattacharya R.   +11 more
europepmc   +2 more sources

Cystathionine β-synthase is involved in cysteine biosynthesis and H₂S generation in Toxoplasma gondii. [PDF]

Sci Rep, 2020
Cystathionine β-synthase (CBS) catalyzes the condensation of serine and homocysteine to water and cystathionine, which is then hydrolyzed to cysteine, α-ketobutyrate and ammonia by cystathionine γ-lyase (CGL) in the reverse transsulfuration pathway.
Conter C, Fruncillo S, Fernández-Rodríguez C, Martínez-Cruz LA, Dominici P, Astegno A.   +5 more
europepmc   +2 more sources

Emerging roles of cystathionine β-synthase in various forms of cancer. [PDF]

Redox Biol, 2022
Ascenção K, Szabo C.
europepmc   +2 more sources

Dual targeting of H₂S synthesizing enzymes; cystathionine β-synthase and cystathionine γ-lyase by miR-939-5p effectively curbs triple negative breast cancer. [PDF]

Heliyon, 2023
Nafea H, Youness RA, Dawoud A, Khater N, Manie T, Abdel-Kader R, Bourquin C, Szabo C, Gad MZ.   +8 more
europepmc   +2 more sources

Disease-causing cystathionine β-synthase linker mutations impair allosteric regulation. [PDF]

J Biol Chem, 2023
Roman JV, Mascarenhas R, Ceric K, Ballou DP, Banerjee R.   +4 more
europepmc   +2 more sources

Role of the cystathionine β-synthase / H₂S pathway in the development of cellular metabolic dysfunction and pseudohypoxia in down syndrome. [PDF]

Redox Biol, 2022
Panagaki T, Pecze L, Randi EB, Nieminen AI, Szabo C.   +4 more
europepmc   +2 more sources

Overproduction of hydrogen sulfide, generated by cystathionine β-synthase, disrupts brain wave patterns and contributes to neurobehavioral dysfunction in a rat model of down syndrome. [PDF]

Redox Biol, 2022
Panagaki T, Lozano-Montes L, Janickova L, Zuhra K, Szabo MP, Majtan T, Rainer G, Maréchal D, Herault Y, Szabo C.   +9 more
europepmc   +2 more sources

Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium [PDF]

, 2015
Urothelium, the epithelial lining the inner surface of human bladder, plays a key role in bladder physiology and pathology. It responds to chemical, mechanical and thermal stimuli by releasing several factors and mediators.
CIRINO, GIUSEPPE, D'EMMANUELE DI VILLA BIANCA, ROBERTA, Donnarumm, Erminia, ESPOSITO, DAVIDE, FUSCO, FERDINANDO, IANARO, ANGELA, MIRONE, VINCENZO, MITIDIERI, EMMA, RUSSO, ANNAPINA, RUSSO, GIULIA, SORRENTINO, RAFFAELLA   +10 more
core   +25 more sources