Results 31 to 40 of about 36,977 (144)

The re-emerging pathophysiological role of the cystathionine-β-synthase - hydrogen sulfide system in Down syndrome.

The FEBS Journal, 2020
Down syndrome (DS) is associated with significant perturbances in many morphological and biochemical features. Cystathionine-β-synthase (CBS) is one of the key mammalian enzymes that is responsible for the biological production of the gaseous transmitter
C. Szabó
semanticscholar   +1 more source

Influence of hyperhomocysteinemia on the cellular redox state - Impact on homocysteine-induced endothelial dysfunction [PDF]

, 2003
Hyperhomocysteinemia is an independent risk factor for the development of atherosclerosis. An increasing body of evidence has implicated oxidative stress as being contributory to homocysteines deleterious effects on the vasculature.
Adachi T, Andersson A, Bagi Z, Bellamy MF, Chambers JC, Chambers JC, Chao CL, Flohé L, Forgione MA, Guttormsen AB, Huang R-FS, Kanani PM, Karlsson K, Lang D, Lentz SR, Mansoor MA, Mansoor MA, Mansoor MA, Mansoor MA, O'Donnell VB, Outinen PA, Pritchard, Rubbo H, Tawakol A, Ungvari Z, Weiss N, Wilcken DE, Woo KS, Zhang F, Zhang X   +29 more
core   +1 more source

Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus. [PDF]

, 2016
Ergothioneine (EGT; 2-mercaptohistidine trimethylbetaine) is a trimethylated and sulphurised histidine derivative which exhibits antioxidant properties. Here we report that deletion of Aspergillus fumigatus egtA (AFUA_2G15650), which encodes a trimodular
A Braunshausen, A Palumbo, A Vit, A Vit, A Wallner, B Halliwell, C Burns, C Collins, C Davis, D Gründemann, DH Scharf, DJ Steenkamp, F Lessing, FP Seebeck, G Pontecorvo, G Rieder, GL Russo, GT Mashabela, GW Jones, H Haas, H Haas, H Oberegger, HS Spies, I Mouyna, J Aguirre, J Carlsson, J Cox, J Ey, KA O’Hanlon, KJ Sheridan, KV Goncharenko, L Gallagher, L Muszkieta, L Servillo, M Deiana, M Eisendle, M Schrettl, M Schrettl, M Schrettl, M Schrettl, M Thon, MH Bello, MH Bello, ML Nielsen, MR Ariyanayagam, NG Markova, OI Aruoma, PK Chang, RA Owens, RC Fahey, RN Vogt, S Carberry, S Paris, S Ravanel, S Sotgia, S Sotgia, SK Dolan, SS Spicer, T Hartmann, T Kubodera, T Pluskal, T Song, TP Holler, W Fang, Ö Sarikaya-Bayram   +64 more
core   +1 more source

Chemical Proteomics Identifies Ketogenesis‐Mediated Cysteine Modifications Regulating Redox Function

Angewandte Chemie, EarlyView.
Herein, we report ketone body induce cysteine modifications beyond lysine acylation, as revealed by integrating chemical proteomics with open‐search methods. Among the modifications, cysteine crotonation (Ccr) was chemically validated by endogenous peptide‐based co‐elution assays.
Yuan‐Fei Zhou, Ling Zhang, Zhuoyi L. Niu, Xin Wang, Alejandro Storper, Ryan Hunt, Yingming Zhao, Nima Sharifi, Zhipeng A. Wang   +8 more
wiley   +2 more sources

Contribution of hydrogen sulfide to the control of coronary blood flow [PDF]

, 2014
This study examined the mechanisms by which H2S modulates coronary microvascular resistance and myocardial perfusion at rest and in response to cardiac ischemia. Experiments were conducted in isolated coronary arteries and in open-chest anesthetized dogs.
Berwick, Zachary C., Casalini, Eli D., Goodwill, Adam G., Moberly, Steven P., Owen, Meredith K., Tune, Johnathan D.   +5 more
core   +1 more source

Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics [PDF]

, 2016
Therapeutic manipulation of the gasotransmitter hydrogen sulfide (H(2)S) has recently been proposed as a novel targeted anticancer approach. Here we show that human lung adenocarcinoma tissue expresses high levels of hydrogen sulfide (H(2)S) producing ...
Druzhyna, Nadiya, Hellmich, Mark R., Marcatti, Michela, Nagy, Péter, Szabo, Csaba, Szczesny, Bartosz, Wiktorowicz, John E., Zatarain, John R.   +7 more
core   +1 more source

A pharmacological probe identifies cystathionine β-synthase as a new negative regulator for ferroptosis

Cell Death and Disease, 2018
Cystathionine β-synthase (CBS) is responsible for the first enzymatic reaction in the transsulfuration pathway of sulfur amino acids. The molecular function and mechanism of CBS as well as that of transsulfuration pathway remain ill-defined in cell ...
Li Wang, H. Cai, Youtian Hu, Fangli Liu, Shengshu Huang, Yue-yang Zhou, Jing Yu, Jinyi Xu, Fang Wu   +8 more
semanticscholar   +1 more source

Efficacy of Novel Aminooxyacetic Acid Prodrugs in Colon Cancer Models: Towards Clinical Translation of the Cystathionine β-Synthase Inhibition Concept

Biomolecules, 2021
Upregulation of hydrogen sulfide (H2S) biosynthesis, at least in part related to the upregulation of cystathionine β-synthetase (CBS) in cancer cells, serves as a tumor-promoting factor and has emerged as a possible molecular target for antitumor drug ...
M. Hellmich, C. Chao, Katalin Módis, Ye Ding, J. Zatarain, K. Thanki, Manjit Maskey, N. Druzhyna, A. Untereiner, Akbar Ahmad, Yu Xue, Haiying Chen, W. Russell, Jianmei Wang, Jia Zhou, C. Szabó   +15 more
semanticscholar   +1 more source

Cystathionine β‐synthase deficiency in the E‐HOD registry‐part I: pyridoxine responsiveness as a determinant of biochemical and clinical phenotype at diagnosis

Journal of Inherited Metabolic Disease, 2020
Cystathionine β‐synthase (CBS) deficiency has a wide clinical spectrum, ranging from neurodevelopmental problems, lens dislocation and marfanoid features in early childhood to adult onset disease with predominantly thromboembolic complications.
V. Kožich, J. Sokolová, A. Morris, M. Pavlíková, F. Gleich, S. Kölker, J. Krijt, C. Dionisi-Vici, M. Baumgartner, H. Blom, M. Huemer   +10 more
semanticscholar   +1 more source

Isolated aortic root dilation in homocystinuria [PDF]

, 2017
BACKGROUND: Vascular complications in homocystinuria have been known for many years, but there have been no reports to date on involvement of the ascending aorta.
Davison, JE, Elliott, PM, Guha, N, Kemp, H, Lachmann, R, Lorenzini, M, Murphy, E, Pandya, B, Pitcher, A   +8 more
core   +2 more sources