Results 111 to 120 of about 12,014 (181)

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, Volume 12, Issue 47, December 18, 2025.
Abstract Aging is a complex, multifaceted process affecting all organ systems, with vascular aging playing a central role in organismal health decline. Beyond its role in circulation, the vascular system acts as a dynamic interface between tissues, influencing countless physiological functions such as tissue regeneration and repair, immune responses ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

Purification and Characterization of Cystathionine γ-Synthase from Thermoacidophilic Archaea Sulfolobus tokodaii [PDF]

, 2010
The gene encoding a cystathionine γ-synthase from Sulfolobus tokodaii was cloned and expressed in Escherihia coli Rosetta-gami (DE3). Cystathionine γ-synthase ［EC 2. 5. 1.
Endou, Yuuichi, Inagaki, Kenji, Kaneda, Shouichirou, Kudou, Daizou, Kuramitsu, Seiki, Shinozaki, Mai, Tamura, Takashi, Yanagitani, Masahiko   +7 more
core  

Regulation of the T-type Ca²⁺ channel Cav3.2 by hydrogen sulfide: Emerging controversies concerning the role of H₂S in nociception [PDF]

, 2015
Ion channels represent a large and growing family of target proteins regulated by gasotransmitters such as nitric oxide, carbon monoxide and, as described more recently, hydrogen sulfide.
Abe, Andersson, Avanzato, Benavides, Berridge, Bezprozvanny, Bourinet, Bourinet, Boycott, Carbone, Catterall, Chemin, Chevalier, Choe, Chris Peers, Clapham, Coste, Cribbs, Dolphin, Dziegielewska, Elies, Emerick, Feng, Francois, Francois, Francois, Gadotti, Garcia-Caballero, Gonzalez, Hsu, Huang, Huguenard, Iftinca, Jackson-Weaver, Jacobo Elies, Jacus, Jagodic, Jagodic, Jason L. Scragg, Jevtovic-Todorovic, John P. Boyle, Joksovic, Kang, Kang, Kawabata, Kim, Kimura, Kuksis, Kuo, Kuo, Latham, Latour, Lee, Lee, Leffler, Li, Li, Lipscombe, Maeda, Marger, Matsunami, Messinger, Moore, Moran, Mustafa, Nagai, Nelson, Nelson, Nelson, Nelson, Nikita Gamper, Nowycky, Orestes, Orestes, Paul, Paul, Peers, Peers, Perez-Reyes, Rajan, Rose, Sekiguchi, Shibuya, Shin, Shipston, Sitdikova, Stadtman, Sun, Szabo, Takahashi, Telezhkin, Todorovic, Todorovic, Todorovic, Todorovic, Tzeng, Wang, Waxman, Weiss, White, Wilkinson, Zamponi, Zhang   +102 more
core   +2 more sources

Habitat Diversity Sustains Ecosystem Functioning in Plateau Arid‐Region Wetlands

Ecology and Evolution, Volume 15, Issue 12, December 2025.
Habitat diversity underpins both biodiversity and functional biogeochemical processes in plateau arid‐region wetlands, thereby stabilizing ecosystem functioning. These functionally complementary habitats collectively drive critical ecosystem processes.
Chenyu Wang, Haicheng Wei, Ronglei Duan, Shi Jin, Jinxin Wen, Hongyu Li, Aiying Cheng, Chunliang Gao, Hongpan Xue, Yilin Hou   +9 more
wiley   +1 more source

H2S Biogenesis by Human Cystathionine γ-Lyase Leads to the Novel Sulfur Metabolites Lanthionine and Homolanthionine and Is Responsive to the Grade of Hyperhomocysteinemia*

Journal of Biological Chemistry, 2009
Although there is a growing recognition of the significance of hydrogen sulfide (H2S) as a biological signaling molecule involved in vascular and nervous system functions, its biogenesis and regulation are poorly understood.
T. Chiku, D. Padovani, Weidong Zhu, Sangita Singh, V. Vitvitsky, R. Banerjee   +5 more
semanticscholar   +1 more source

Anomalous Kv 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H2 S and persulfidation in skeletal muscle. [PDF]

BACKGROUND AND PURPOSE: Human malignant hyperthermia (MH) syndrome is induced by volatile anaesthetics and involves increased levels of cystathionine β-synthase (CBS)-derived H2 S within skeletal muscle.
Basso Elisabetta, Maria, Bibli Iris, Sophia, Bucci, Mariarosaria, Calderone, Vincenzo, Cirino, Giuseppe., Citi, Valentina, Cozzolino, Catia, de Dominicis, Gianfranco, Fleming, Ingrid, Mancini, Antonio, Manzo, ONORINA LAURA, Mariniello, Martina, Martelli, Alma, Panza, Elisabetta, Vallifuoco, Marianna, Vellecco, Valentina   +15 more
core   +1 more source

The anti-proliferative and anti-inflammatory response of COPD airway smooth muscle cells to hydrogen sulfide [PDF]

, 2018
BACKBROUND: COPD is a common, highly debilitating disease of the airways, primarily caused by smoking. Chronic inflammation and structural remodelling are key pathological features of this disease caused, in part, by the aberrant function of airway ...
Adcock, Ian, Caramori, Gaetano, Casolari, Paolo, Chung, Kian Fan, Halayko, Andrew J., Papi, Alberto, Perry, Mark M., Rempel, Karen Limbert, Tildy, Bernadett   +8 more
core   +1 more source

An Improved Two‐Step Collagenase Perfusion Protocol for Isolation of Mouse Primary Hepatocytes

Future Postharvest and Food, Volume 2, Issue 4, Page 474-477, December 2025.
An improved two‐step protocol for isolation of mouse primary hepatocytes by inserting needles into the portal vein and cutting of the inferior vena cava. ABSTRACT In metabolic dysfunction‐associated steatotic liver disease (MASLD) or diabetes mechanistic studies, cellular experiments are frequently required.
Xiaopeng Li
wiley   +1 more source

3-Mercaptopyruvate Sulfurtransferase, Not Cystathionine β-Synthase Nor Cystathionine γ-Lyase, Mediates Hypoxia-Induced Migration of Vascular Endothelial Cells

Frontiers in Pharmacology, 2017
Hypoxia-induced angiogenesis is a common phenomenon in many physiological and patho-physiological processes. However, the potential differential roles of three hydrogen sulfide producing systems cystathionine γ-lyase (CSE)/H2S, cystathionine β-synthase ...
Beibei Tao, Rui Wang, Chen Sun, Yichun Zhu   +3 more
doaj   +1 more source

Cystathionine-γ-lyase promotes the metastasis of breast cancer via the VEGF signaling pathway

International Journal of Oncology, 2019
The present study aimed to provide data to support the association between cystathionine-γ-lyase (CSE) and breast cancer metastasis. Reverse transcription-quantitative polymerase chain reaction, immunohistochemistry and western blot analysis were used to
Lupeng Wang, HAI-MIN Shi, Ya Liu, Weiyuan Zhang, Xiaofan Duan, Ming Li, Xiaoyan Shi, Tianxiao Wang   +7 more
semanticscholar   +1 more source