Results 121 to 130 of about 12,014 (181)

ON THE ROLE OF CYSTATHIONINE-γ-LYASE IN MODULATING TRANSSULFURATION PATHWAY IN THE LENS [PDF]

In Mammals transsulfuration pathway enables the conversion of homocysteine (Hcy), deriving from methionine (Met) transmetilation, into cysteine (Cys) through two steps, the first catalyzed by cystathionine β-synthase (CBS) and the second one by ...
CALVANI, ENRICA
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Gasotransmitters: novel regulators of ion channels and transporters [PDF]

, 2013
More than 25 years ago, it was a big surprise for physiologists that nitric oxide (NO) was identified as the endothelium derived relaxing factor which is responsible for endothelium-induced smooth muscle relaxation (Ignarro et al., 1987).
Mike Althaus, Wolfgang G. Clauss
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Nuclear localised more sulphur accumulation1 epigenetically regulates sulphur homeostasis in Arabidopsis thaliana [PDF]

, 2016
Sulphur (S) is an essential element for all living organisms. The uptake, assimilation and metabolism of S in plants are well studied. However, the regulation of S homeostasis remains largely unknown.
A Becker, A Goyer, A Maruyama-Nakashita, A Maruyama-Nakashita, A Maruyama-Nakashita, AD Hanson, AD Hanson, AF Pendle, AM Catanzariti, Anna Koprivova, B Lahner, B Shane, BR Lee, Brian Dilkes, CG Kawashima, CG Kawashima, D Gorlich, D Mao, D Secco, Dai-Yin Chao, David E Salt, DY Chao, Francisco J. Sandoval, G Liang, G Tsakraklides, GZ Luo, H Bauwe, H Rouached, H Takahashi, H Takahashi, H Tian, H Zhang, Hermann Bauwe, HM Hubberten, HR Zhou, JA Law, John Danku, K Arnold, K Burstenbinder, L Schirch, L Yong-Villalobos, L Yong-Villalobos, LM Voll, M Barberon, M Bielecka, M Eisenhut, M Sauter, Markus Wirtz, MW Jones-Rhoades, MY Hirai, N Engel, N Guex, N Terry, N Yoshimoto, N Yoshimoto, PP Sahu, PS Hosmani, RT Taylor, Rüdiger Hell, S Alfadhli, S Kosugi, S Lee, S Li, S Liu, Sanja Roje, SG Mugford, SJ Clough, Stanislav Kopriva, Steffen Müller, T Fujiwara, T Kamiya, T Leustek, T Matsushita, TF Fu, Thomas Leustek, TT Calikowski, V Chinnusamy, V Schirch, W Huang da, W Wen, WA Loenen, X Zhang, Xin-Yuan Huang, XY Huang, XY Huang, Y Hacham, Y Wan, Y Xi, Y Zhang, Y Zhang, Z Wei   +90 more
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Hydrogen sulfide and its role in female reproduction

Frontiers in Veterinary Science
Hydrogen sulfide (H2S) is a gaseous signaling molecule produced in the body by three enzymes: cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST).
Aneta Pilsova, Zuzana Pilsova, Barbora Klusackova, Natalie Zelenkova, Eva Chmelikova, Pavla Postlerova, Marketa Sedmikova   +6 more
doaj   +1 more source

Overexpression of Cystathionine γ-Lyase Suppresses Detrimental Effects of Spinocerebellar Ataxia Type 3 [PDF]

, 2019
Spinocerebellar ataxia type 3 (SCA3) is a polyglutamine (polyQ) disorder caused by a CAG repeat expansion in the ataxin-3 (ATXN3) gene resulting in toxic protein aggregation. Inflammation and oxidative stress are considered secondary factors contributing
Baratashvili, Madina, Bos, Eelke M., den Dunnen, Wilfred F. A., Dijkers, Pascale F., Filipovic, Milos R., Giepmans, Ben N. G., Grzeschik, Nicola A., Huitema, Sippie, Kampinga, Harm H., Kuijpers, Lucas, Kuipers, Jeroen, Leuvenink, Henri G. D., Miljkovic, Jan Lj, Mitrovic, Aleksandra, Schaap, Onno, Sibon, Ody C. M., Snijder, Pauline M., Szabó, Csaba, van Goor, Harry   +18 more
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Significance of Hydrogen Sulfide Production in the Pancreatic β-Cell

Journal of Pharmacological Sciences, 2011
.: Hydrogen sulfide (H2S) is an important signaling molecule in various mammalian cells and tissues. H2S is synthesized from l-cysteine and regulates several cellular and physiological phenomena (vasorelaxation, hormone secretion, and apoptosis) and ...
Shigeki Taniguchi, Ichiro Niki
doaj   +1 more source

Inhibition of cystathionine gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity [PDF]

, 2012
Clinical use of gentamicin over prolonged periods is limited because of dose- and time-dependent nephrotoxicity. Primarily, lysosomal phospholipidosis, intracellular oxidative stress and heightened inflammation have been implicated.
Dam Van Phai,, Kinober, Robert T., Ross, Anthony, Scott, Jennifer L.   +3 more
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Effects of inhibiting antioxidant pathways on cellular hydrogen sulfide and polysulfide metabolism [PDF]

, 2019
Elaborate antioxidant pathways have evolved to minimize the threat of excessive reactive oxygen species (ROS) and to regulate ROS as signaling entities.
Gao, Yan, Olson, Kenneth R.
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THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Enzymes [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,, Alexander, Stephen Ph, Davies, Jamie A, Fabbro, Doriano, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
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Allosteric activators of cystathionine γ lyase to augment endogenous hydrogen sulfide and inhibit pathologic calcification

Pharmacological Research
Hydrogen sulfide (H₂S), a gasotransmitter naturally produced in the body by enzymes such as cystathionine γ lyase (CSE), helps reduce inflammation, oxidative stress, and abnormal tissue calcification.
Sonia Nasi, Driss Ehirchiou, Cindy Blatter, Veronique Chobaz, Stefan Germann, Alexandra Brandenberger, Elias Bommeli, Emiko Uchikawa, Giuseppe Cirino, Rainer Riedl, Alexander So, Nathalie Busso   +11 more
doaj   +1 more source