Results 131 to 140 of about 12,014 (181)

Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE)

British Journal of Pharmacology, 2013
Hydrogen sulfide (H2S) is a signalling molecule that belongs to the gasotransmitter family. Two major sources for endogenous enzymatic production of H2S are cystathionine β synthase (CBS) and cystathionine γ lyase (CSE). In the present study, we examined
Antonia Asimakopoulou, Panagiotis Panopoulos, Christos T. Chasapis, C. Coletta, Zongmin Zhou, G. Cirino, A. Giannis, C. Szabó, G. Spyroulias, A. Papapetropoulos   +9 more
semanticscholar   +1 more source

Urothelium muscarinic activation phosphorylates CBS Ser227 via cGMP/PKG pathway causing human bladder relaxation through H 2 S production [PDF]

, 2016
The urothelium modulates detrusor activity through releasing factors whose nature has not been clearly defined. Here we have investigated the involvement of H2S as possible mediator released downstream following muscarinic (M) activation, by using human ...
CIRINO, GIUSEPPE, D'EMMANUELE DI VILLA BIANCA, ROBERTA, DONNARUMMA, ERMINIA, FUSCO, FERDINANDO, MIRONE, VINCENZO, MITIDIERI, EMMA, Pagliara, Valentina, RUSSO, ANNAPINA, RUSSO, GIULIA, SORRENTINO, RAFFAELLA, Tramontano, Teresa   +10 more
core   +1 more source

Hydrogen sulfide and inflammatory joint diseases [PDF]

, 2017
[Abstract] Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are widespread rheumatic diseases characterized by persistent inflammation and joint destruction. Hydrogen sulfide (H2S) is an endogenous gas with important physiologic functions in
Blanco García, Francisco J, Burguera, Elena F., Meijide-Faílde, Rosa   +2 more
core   +2 more sources

Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap

Biology Open, 2015
In addition to its role in the endogenous synthesis of cysteine, cystathionine gamma-lyase (CGL) is a major physiological source of the vasorelaxant hydrogen sulfide.
Hua Jiang, K. Joseph Hurt, Kelsey Breen, Sally P. Stabler, Robert H. Allen, David J. Orlicky, Kenneth N. Maclean   +6 more
doaj   +1 more source

Hydrogen sulfide/polysulfides signaling and neuronal diseases

Neurotherapeutics
Hydrogen sulfide (H2S) and polysulfides including H2Sn (n ​= 2 or more) regulate neuronal activity, vascular tone, oxytosis/ferroptosis, oxygen sensing, cancer growth and senescence.
Hideo Kimura
doaj   +1 more source

H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase

Science, 2008
Guangdong Yang, Lingyun Wu, B. Jiang, Wei Yang, J. Qi, Kun Cao, Q. Meng, A. Mustafa, W. Mu, Shengming Zhang, S. Snyder, Rui Wang   +11 more
semanticscholar   +1 more source

Enzymes that generate and regulate intracellular persulfides and polysulfides: mechanistic insights and inhibitors

Frontiers in Physiology
Reactive sulfur species (RSS), which include various persulfides and polysulfides, are generated by multiple enzymes in vivo and play critical roles in mammalian physiological processes such as redox signaling, metabolic regulation, radical scavenging ...
Ko Hirabayashi, Eita Sasaki, Hisashi Ohno, Orie Takayama, Sota Yamada, Kenjiro Hanaoka, Kenjiro Hanaoka   +6 more
doaj   +1 more source

Arylthioamides and aryliminothioethers as new slow H2S-releasing agents [PDF]

Hydrogen sulphide (H2S) is emerging as an important endogenous modulator, which exhibits the beneficial effects of nitric oxide (NO) on the cardiovascular (CV) system, without producing toxic metabolites.
ANGELINI, MARIAGRAZIA
core  

The impact of fish oil fatty-acids on post-prandial vascular reactivity. [PDF]

, 2014
Progressive loss of vascular reactivity and increased vascular tone with age are being increasingly recognised as significant cardiovascular disease (CVD) risk factors.
Mcmanus, Sean
core  

Role of Sex and Early Life Stress Experience on Porcine Cardiac and Brain Tissue Expression of the Oxytocin and H₂S Systems

Biomolecules
Early life stress (ELS) significantly increases the risk of chronic cardiovascular diseases and may cause neuroinflammation. This post hoc study, based on the material available from a previous study showing elevated “serum brain injury markers” in male ...
Franziska Münz, Nadja Abele, Fabian Zink, Eva-Maria Wolfschmitt, Melanie Hogg, Claus Barck, Josef Anetzberger, Andrea Hoffmann, Michael Gröger, Enrico Calzia, Christiane Waller, Peter Radermacher, Tamara Merz   +12 more
doaj   +1 more source