Results 91 to 100 of about 956,103 (191)

Mesenchymal Stem Cells Alleviate Crohn's Disease by Regulating CBS‐Mediated Ferroptosis

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
MSCs alleviate CD by regulating CBS‐mediated ferroptosis. Bioinformatics analysis identified CBS as a hub gene shared by CD and ferroptosis. In TNBS‐induced colitis mice, MSCs treatment alleviated intestinal inflammation by upregulating CBS expression, increasing GSH and GPX4 levels, and inhibiting ferroptosis.
Zhixi Huang, Xiaofang Xu, Zhou Huang, Bing Han, Dan Jiang, Xiaodan Lv, Ziqian Huang, Guangfu Lin, Fengxiang Huang, Yu Li, Lichun Han, Deyi Chen, Jianing Lin, Xiaoping Lv   +13 more
wiley   +1 more source

Asymmetric dimethylarginine in adults with cystathionine beta-synthase deficiency.

, 2012
Item does not contain fulltextIn hyperhomocysteinemia (HHcy), an independent risk factor for cardiovascular diseases, endothelial dysfunction due to reduced bioavailability of nitric oxide is a consistent finding.
Rivera, I., Rocha, M.S., Tavares de Almeida, I., Kluijtmans, L.A.J., Janssen, M.C.H., Teerlink, T., Castro, R., Jakobs, C., Blom, H.J., Smulders, Y.   +9 more
core   +1 more source

Engineering of methionine-auxotroph Escherichia coli via parallel evolution of two enzymes from Corynebacterium glutamicum's direct-sulfurylation pathway enables its recovery in minimal medium

Metabolic Engineering Communications
Methionine biosynthesis relies on the sequential catalysis of multiple enzymes. Escherichia coli, the main bacteria used in research and industry for protein production and engineering, utilizes the three-step trans-sulfurylation pathway catalyzed by L ...
Matan Gabay, Inbar Stern, Nadya Gruzdev, Adi Cohen, Lucia Adriana-Lifshits, Tamar Ansbacher, Itamar Yadid, Maayan Gal   +7 more
doaj   +1 more source

Platelet and monocyte variables in homocystinuria due to cystathionine-beta-synthase deficiency

Haematologica, 1997
To gain insight into the mechanisms responsible for enhanced thromboxane (TX) A2 biosynthesis in homozygous homocystinuria due to cystathionine-beta-synthase deficiency (CBSD), we measured a series of platelet and monocyte variables in 9 homozygous and 8
A Coppola, R Albisinni, P Madonna, A Pagano, AM Cerbone, G Di Minno   +5 more
doaj  

Muscarinic receptor drug trihexyphenidyl can alter growth of mesenchymal glioblastoma in vivo

Frontiers in Pharmacology
Glioblastoma (GBM) is the most commonly occurring and most aggressive primary brain tumor. Transcriptomics-based tumor subtype classification has established the mesenchymal lineage of GBM (MES-GBM) as cancers with particular aggressive behavior and high
Renfei Du, Renfei Du, Ahmed Y. Sanin, Wenjie Shi, Bing Huang, Bing Huang, Ann-Christin Nickel, Andres Vargas-Toscano, Shuran Huo, Thomas Nickl-Jockschat, Claudia A. Dumitru, Wei Hu, Siyu Duan, I. Erol Sandalcioglu, Roland S. Croner, Joshua Alcaniz, Wolfgang Walther, Carsten Berndt, Ulf D. Kahlert   +18 more
doaj   +1 more source

First National Expanded Genomic Newborn Screening Program in Qatar; A Pilot Study, Doha‐Heidelberg Collaboration

American Journal of Medical Genetics Part A, Volume 200, Issue 10, Page 2374-2380, October 2026.
Reem Alsulaiman, Sarah Okashah, Radja Messai Badji, Fatemeh Abbaszadeh, Yaser Alsarraj, Rehab Ali Abdulrahman, Noora Shahbeck, Thalib Moideen, Reema El Hassan, Fatima Al‐Hamaydeh, Einas Alkuwari, Said Ismail, Hilal Al‐ Rifai, Ghassan Abdoh, Christian P. Schaaf, Georg Hoffmann, Saad Al‐Kaabi, Wadha Al‐Muftah, Tawfeg Ben‐Omran   +18 more
wiley   +1 more source

Domain Organization, Catalysis and Regulation of Eukaryotic Cystathionine Beta-Synthases

PLoS ONE, 2014
Cystathionine beta-synthase (CBS) is a key regulator of sulfur amino acid metabolism diverting homocysteine, a toxic intermediate of the methionine cycle, via the transsulfuration pathway to the biosynthesis of cysteine. Although the pathway itself is well conserved among eukaryotes, properties of eukaryotic CBS enzymes vary greatly.
Majtan, Tomas, Pey Rodríguez, Ángel Luis, Fernández, Roberto, Fernández, José A., Martínez-Cruz, Luis A., Kraus, Jan P.   +5 more
openaire   +6 more sources

Homocystinuria: studies on cystathionine beta-synthase, S-adenosylmethionine synthetase and cystathionase activities in skin fibroblasts

, 1981
Cystathionine beta-synthase, S-adenosylmethionine synthetase and cystathionase activities were assayed in skin fibroblast cultures from five pyridoxine responsive and five pyridoxine non-responsive homocystinurics, six obligate heterozygotes for ...
Carson, N.A., Bittles, A.H.
core  

Newborn Population Screening for Classic Homocystinuria by Determination of Total Homocysteine from Guthrie Cards

, 2010
Objective To allow early recognition of cystathionine beta-synthase by newborn ...
AL KHAL, Abdul Latif, HOFFMANN, Georg F., BEN-OMRAN, Tawfeg, LINDNER, Martin, Bener, Abdulbari, SHAHBEK, Noora, ZSCHOCKE, Johannes, FANG-HOFFMANN, Junmin, AL RIFAI, Hilal, WILRICH, Julia, KEBBEWAR, Moustafa, GAN-SCHREIER, Hongying, ABDOH, Ghassan, Junmin Fang-Hoffmann, Ghassan Abdoh, Tawfeg Ben-Omran, Hongying Gan-Schreier, Hilal Al Rifai, Noora Shahbek, Johannes Zschocke, Abdul Latif Al Khal, Martin Lindner, Abdulbari Bener, Georg F. Hoffmann, Moustafa Kebbewar, Julia Wilrich   +25 more
core   +1 more source

Sulfur Amino Acid Levels and Related Enzyme Activities in Various Brain Regions (and Other Tissues) in Normal Mice and Rolling Mice Nagoya [PDF]

, 1992
The contents of the sulfur amino acids, and the activities of cystathionine beta-synthase and cystathionine gamma-lyase were measured in various regions of the brain and several other tissues in both normal mice and rolling mice Nagoya. The cystathionine
Kodama, Hiroyuki, Hiroi, Tadashi, Ikeda, Hisao, Myojin, Kazuhiro   +3 more
core   +1 more source