Results 101 to 110 of about 956,103 (191)

Structural insights into mutations of cystathionine beta-synthase

, 2003
Cystathionine beta-synthase (CBS) is a unique heme-containing enzyme that catalyses a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of
Kraus, J. P., Oliveriusova, J., Burkhard, P., Meier, M.   +3 more
core  

Hydrogen Sulfide Signaling Axis as a Target for Prostate Cancer Therapeutics

Prostate Cancer, 2016
Hydrogen sulfide (H2S) was originally considered toxic at elevated levels; however just in the past decade H2S has been proposed to be an important gasotransmitter with various physiological and pathophysiological roles in the body.
Mingzhe Liu, Lingyun Wu, Sabine Montaut, Guangdong Yang   +3 more
doaj   +1 more source

Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium. [PDF]

, 2015
Urothelium, the epithelial lining the inner surface of human bladder, plays a key role in bladder physiology and pathology. It responds to chemical, mechanical and thermal stimuli by releasing several factors and mediators.
SORRENTINO, RAFFAELLA, Angela Ianaro, Giuseppe Cirino, Raffaella Sorrentino, Ferdinando Fusco, RUSSO, GIULIA, Erminia Donnarumma, RUSSO, ANNAPINA, CIRINO, GIUSEPPE, Emma Mitidieri, MITIDIERI, EMMA, IANARO, ANGELA, Davide Esposito, Giulia Russo, Roberta d'Emmanuele di Villa Bianca, Donnarumm, Erminia, Vincenzo Mirone, Annapina Russo, ESPOSITO, DAVIDE, MIRONE, VINCENZO, FUSCO, FERDINANDO, D'EMMANUELE DI VILLA BIANCA, ROBERTA, Ianaro Angela, Sorrentino Raffaella, Donnarumm Erminia, Mirone Vincenzo, d’Emmanuele di Villa Bianca Roberta, Esposito Davide, Cirino Giuseppe, Russo Annapina, Fusco Ferdinando, Mitidieri Emma, Russo Giulia   +32 more
core   +2 more sources

Unraveling CBS Mutations and Their Clinical Impact in a Chinese Family With Classical Homocystinuria

Molecular Genetics & Genomic Medicine
Background Classical homocystinuria (HCU), caused by cystathionine beta‐synthase (CBS) deficiency, exhibits significant geographic variability in its mutational spectrum.
Jingfei Zhang, Xinyu Lin, Xinmei Liu, Yilu Lu, Dachang Tao, Dan Yu, Yongxin Ma   +6 more
doaj   +1 more source

Bridging the Gap in Cancer Research: Sulfur Metabolism of Leukemic Cells with a Focus on L-Cysteine Metabolism and Hydrogen Sulfide-Producing Enzymes

Biomolecules
Leukemias are cancers of the blood-forming system, representing a significant challenge in medical science. The development of leukemia cells involves substantial disturbances within the cellular machinery, offering hope in the search for effective ...
Konrad Kaleta, Klaudia Janik, Leszek Rydz, Maria Wróbel, Halina Jurkowska   +4 more
doaj   +1 more source

Hydrogen Sulfide Reduces Myeloid-Derived Suppressor Cell-Mediated Inflammatory Response in a Model of Helicobacter hepaticus-Induced Colitis

Frontiers in Immunology, 2018
Chronic inflammation contributes to tumor initiation in colitis-associated colorectal cancer (CRC). Indeed, inflammatory bowel disease (IBD) patients show an increased risk of developing CRC.
Paola De Cicco, Theodore Sanders, Giuseppe Cirino, Kevin J. Maloy, Angela Ianaro   +4 more
doaj   +1 more source

Dioxygen reactivity and heme redox potential of truncated human cystathionine beta-synthase.

, 2008
Cystathionine beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to cystathionine, which represents the committing step in the transsulfuration pathway.
Banerjee, Ruma, Madzelan, Peter, Alvarez, Beatriz, Radi, Rafael, Zinola, Carlos F, Graña, Martín, Carballal, Sebastián   +6 more
core   +1 more source

Recurrent venous thrombosis in an adolescent male with CBS mutation and persistent antiphospholipid antibody positivity: a case report

Thrombosis Journal
Homocysteine (Hcy) contributes to endothelial dysfunction and impaired thrombolysis, and genetic polymorphisms that elevate plasma Hcy concentrations have been linked to an increased risk of thrombosis. Notably, mutations in the cystathionine β-synthase (
Yuebing Wang, Ru Li, Chun Li
doaj   +1 more source

Amplification of phenylalanine hydroxylase and cystathionine beta-synthase transcripts in human peripheral lymphocytes by RT-PCR

, 1998
A simple, rapid, reliable and convenient method was developed to analyze the gene defects in Phenylketonuria (PKU) and Homocystinuria (HCU). In this method, illegitimately transcribed phenylalanine hydroxylase (PAH) and cystathionine beta-synthase (CBS ...
Devi, AR, Kondaiah, P, Devi, KS
core  

Enhancing Postharvest Quality of Fresh-Cut Changgen Mushrooms by Exogenous L-Cysteine Treatment: Aspects of Accumulating Amino Acids, Triggering Energy Metabolism and Enhancing Endogenous H₂S Regulation

Foods
As a rare and functional edible mushroom, the market potential of ready-to-eat fresh-cut Changgen mushrooms (Oudemansiella raphanipes) is booming in developing countries.
Xingchi Ma, Tianhao Li, Weijian Mao, Yu Zhang, Haoran Liu, Wenwen Jiang, Yanan Sun, Hao Yu, Fansheng Cheng, Dan Zhu   +9 more
doaj   +1 more source