Results 21 to 30 of about 975,983 (211)

Cellular turnover and degradation of the most common missense cystathionine beta-synthase variants causing homocystinuria. [PDF]

Protein Sci
Homocystinuria (HCU) due to cystathionine beta‐synthase (CBS) deficiency is the most common inborn error of sulfur amino acid metabolism. Recent work suggests that missense pathogenic mutations—regardless of their topology—cause instability of the C ...
Mijatovic E, Ascenção K, Szabo C, Majtan T.   +3 more
europepmc   +2 more sources

Benserazide, a cystathionine beta-synthase (CBS) inhibitor, potentially enhances the anticancer effects of paclitaxel via inhibiting the S-sulfhydration of SIRT1 and the HIF1-α/VEGF pathway. [PDF]

Front Pharmacol
Cancer targeted therapy is essential to minimize damage to normal cells and improve treatment outcomes. The elevated activity of Cystathionine beta-synthase (CBS), an enzyme responsible for producing endogenous hydrogen sulfide (H2S), plays a significant
Zhao W, Feng S, Wang J, Zhang Z, Chen L, Jiang L, Li M, Wang T.   +7 more
europepmc   +2 more sources

Huntingtin interacts with cystathionine beta-synthase [PDF]

Human Molecular Genetics, 1998
We have screened a rat brain library to identify proteins which interact with the 5'-end of huntingtin (amino acids 1-171), including the polyglutamine tract, in the yeast two-hybrid system.
Wood, J. D., Jones, Lesley, Harper, P. S., Boutell, J. M.   +3 more
core   +3 more sources

Cystathionine Beta-Synthase [PDF]

Definitions, 2020
CBS1 from Magnaporthe grisea is a structural and functional homolog of the cystathionine beta synthase (CBS) gene from Saccharomyces cerevisiae . Our studies indicated that M.
D. Schomburg, M. Salzmann
semanticscholar   +3 more sources

Homocystinuria due to cystathionine beta synthase deficiency [PDF]

Indian Journal of Dermatology, Venereology and Leprology, 2008
A two year-old male child presented with cutis marmorata congenita universalis, brittle hair, mild mental retardation, and finger spasms. Biochemical findings include increased levels of homocysteine in the blood-106.62 µmol/L (normal levels: 5.90-16µmol/
Ahmed, Kamal, Guruprasad, P, Radhakrishna, K, Mohana, Rao TS, Rao, T Narayana   +4 more
core   +3 more sources

Cystathionine beta synthase regulates mitochondrial dynamics and function in endothelial cells. [PDF]

FASEB J, 2020
Mutations in the human cystathionine beta synthase (CBS) gene are known to cause endothelial dysfunction responsible for cardiovascular and neurovascular diseases. CBS is the predominant hydrogen sulfide (H2S)‐producing enzyme in endothelial cells (ECs).
Rao G, Murphy B, Dey A, Dwivedi SKD, Zhang Y, Roy RV, Chakraborty P, Bhattacharya R, Mukherjee P.   +8 more
europepmc   +2 more sources

Cystathionine beta-synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance. [PDF]

PLoS ONE, 2013
Epithelial ovarian cancer is the leading cause of gynecologic cancer deaths. Most patients respond initially to platinum-based chemotherapy after surgical debulking, however relapse is very common and ultimately platinum resistance emerges. Understanding
Sanjib Bhattacharyya, Sounik Saha, Karuna Giri, Ian R Lanza, K Sreekumar Nair, Nicholas B Jennings, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Eati Basal, Amy L Weaver, Daniel W Visscher, William Cliby, Anil K Sood, Resham Bhattacharya, Priyabrata Mukherjee   +14 more
doaj   +2 more sources

Increased expression of cystathionine beta-synthase and chemokine ligand 21 is closely associated with poor prognosis in extrahepatic cholangiocarcinoma. [PDF]

Medicine (Baltimore), 2020
The expression of Cystathionine beta-synthase (CBS) and Chemokine ligand 21 (CCL21) is associated with the tumorigenesis and progression of a variety of tumors, but whether alterations in their expression levels correlates with the carcinogenesis and ...
Wang L, Yang Z, Wu Z, He J, Xu S, Li D, Zou Q, Yuan Y.   +7 more
europepmc   +2 more sources

Cystathionine beta-synthase deficiency causes fat loss in mice. [PDF]

PLoS ONE, 2011
Cystathionine beta synthase (CBS) is the rate-limiting enzyme responsible for the de novo synthesis of cysteine. Patients with CBS deficiency have greatly elevated plasma total homocysteine (tHcy), decreased levels of plasma total cysteine (tCys), and ...
Sapna Gupta, Warren D Kruger
doaj   +4 more sources

A refined total capsular bag suspension technique for lens subluxation from cystathionine beta-synthase deficiency: A case report and literature review. [PDF]

Am J Ophthalmol Case Rep
Purpose: To report the application of a refined total capsular bag suspension technique for lens subluxation from Cystathionine beta-synthase (CBS) deficiency.
Lu Y, Jiang Y, Wang Z.
europepmc   +2 more sources