Results 41 to 50 of about 975,983 (211)

Aging / Cystathionine beta synthase modulates senescence of human endothelial cells

Aging, 2012
Availability of methionine is known to modulate the rate of aging in model organisms, best illustrated by the observation that dietary methionine restriction extends the lifespan of rodents. However, the underlying mechanisms are incompletely understood.
Albertini, Eva, Koziel, Rafal, Neuhaus, Michael, Jansen-Dürr, Pidder, Dürr, Angela   +4 more
core   +4 more sources

Thoracic Aortic Dissection in a Patient With Classical Homocystinuria: Implications for Aortic Surveillance. [PDF]

JIMD Rep
Classical homocystinuria (OMIM #236300), a rare inherited metabolic disorder caused by cystathionine beta‐synthase (CBS) deficiency, is characterized by markedly elevated homocysteine levels and associated multisystem complications.
Chard M, Zhang JS, Turner L.
europepmc   +2 more sources

Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease

Antioxidants, 2023
3-mercaptopyruvate sulfurtransferase (3-MST) plays the important role of producing hydrogen sulfide. Conserved from bacteria to Mammalia, this enzyme is localized in mitochondria as well as the cytoplasm. 3-MST mediates the reaction of 3-mercaptopyruvate
Swetha Pavani Rao, Prakashkumar Dobariya, Harshini Bellamkonda, Swati S. More   +3 more
doaj   +1 more source

Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70. [PDF]

PLoS Genetics, 2010
Missense mutant proteins, such as those produced in individuals with genetic diseases, are often misfolded and subject to processing by intracellular quality control systems. Previously, we have shown using a yeast system that enzymatic function could be
Laishram R Singh, Sapna Gupta, Nicholaas H Honig, Jan P Kraus, Warren D Kruger   +4 more
doaj   +1 more source

Key substrate recognition residues in the active site of cystathionine beta‐synthase from Toxoplasma gondii

Proteins: Structure, Function, and Bioinformatics, 2023
Cystathionine β‐synthase (CBS) catalyzes the condensation of l‐serine and l‐homocysteine to give l‐cystathionine in the transsulfuration pathway.
C. Conter, F. Favretto, P. Dominici, L. Martínez-Cruz, A. Astegno   +4 more
semanticscholar   +1 more source

Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine β-synthase [PDF]

Proceedings of the National Academy of Sciences, 2010
The catalytic potential for H 2 S biogenesis and homocysteine clearance converge at the active site of cystathionine β-synthase (CBS), a pyridoxal phosphate-dependent enzyme. CBS catalyzes β-replacement reactions of either serine or cysteine by homocysteine to give cystathionine and water or ...
Markos, Koutmos, Omer, Kabil, Janet L, Smith, Ruma, Banerjee   +3 more
openaire   +2 more sources

Inactivation of cystathionine β-synthase with peroxynitrite [PDF]

Archives of Biochemistry and Biophysics, 2009
Cystathionine beta-synthase (CBS) is a homocysteine metabolizing enzyme that contains pyridoxal phosphate (PLP) and a six-coordinate heme cofactor of unknown function. CBS was inactivated by peroxynitrite, the product of nitric oxide and superoxide radicals. The IC(50) was approximately 150microM for 5microM ferric CBS.
Laura, Celano, Magdalena, Gil, Sebastián, Carballal, Rosario, Durán, Ana, Denicola, Ruma, Banerjee, Beatriz, Alvarez   +6 more
openaire   +2 more sources

Vascular presentation of cystathionine beta‐synthase deficiency in adulthood [PDF]

Journal of Inherited Metabolic Disease, 2010
AbstractSeveral recent studies describing a solely vascular presentation of cystathionine beta‐synthase (CBS) deficiency in adulthood prompted us to analyze the frequency of patients manifesting with vascular complications in the Czech Republic. Between 1980 and 2009, a total of 20 Czech patients with CBS deficiency have been diagnosed yielding an ...
Magner, Martin, Krupková, Lucie, Honzík, Tomáš, Zeman, Jiří, Hyánek, Josef, Kožich, Viktor   +5 more
openaire   +2 more sources

Epigallocatechin gallate is a potent inhibitor of cystathionine beta-synthase: Structure-activity relationship and mechanism of action.

Nitric oxide, 2022
Epigallocatechin gallate (EGCG) is the main bioactive component of green tea. Through screening of a small library of natural compounds, we discovered that EGCG inhibits cystathionine β-synthase (CBS), a major H2S-generating enzyme.
Karim Zuhra, M. Petrosino, Barkha Gupta, T. Panagaki, Marco Cecconi, V. Myrianthopoulos, R. Schneiter, E. Mikros, T. Majtan, C. Szabó   +9 more
semanticscholar   +1 more source

The endogenous production of hydrogen sulphide in intrauterine tissues [PDF]

, 2009
Background: Hydrogen sulphide is a gas signalling molecule which is produced endogenously from L-cysteine via the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).
Patel Pushpa, Carson Ray J, Patel, Pushpa, Heptinstall, John, Heptinstall, J, Wang, Rui, Carson, RJ, Rui Wang, John Heptinstall (7594472), Pushpa Patel, Carson, Ray J., Pushpa Patel (2697712), Heptinstall John, Rui Wang (52434), Vatish Manu, Vatish, M, Ray J Carson, Manu Vatish (187260), Wang Rui, Wang, R, Ray J. Carson (7594475), Vatish, Manu, Manu Vatish, John Heptinstall   +23 more
core   +1 more source