Results 61 to 70 of about 12,878 (190)

The Role of CBS in Injury Time Estimation after Brain Contusion [PDF]

Fayixue Zazhi, 2017
Objective To observe the changes of cystathionine β-synthase （CBS） expression in the cerebral cortex after brain contusion at different times. Methods An experimental model of traumatic brain injury （TBI） in mice was established by an improved weight ...
CHU YANG, HAN GUO-XIAN, WANG YAO-QI, ET AL.
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Genetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians. [PDF]

, 2015
Plasma homocysteine, a metabolite involved in key cellular methylation processes seems to be implicated in cognitive functions and cardiovascular health with its high levels representing a potential modifiable risk factor for Alzheimer’s disease (AD ...
Baiyewu, Olusegun, Doraiswamy, P. Murali, Foroud, Tatiana M., Gao, Sujuan, Gureje, Oye, Hall, Kathleen S., Hendrie, Hugh C., Kaddurah-Daouk, Rima, Kim, Sungeun, Kling, Mitchel A., Lai, Dongbing, Lane, Katie, Murrell, Jill R., Nho, Kwangsik, Ogunniyi, Adesola, Ramanan, Vijay K., Saykin, Andrew J., Unverzagt, Frederick W.   +17 more
core   +1 more source

Cystathionine beta synthase modulates senescence of human endothelial cells

Aging, 2012
Availability of methionine is known to modulate the rate of aging in model organisms, best illustrated by the observation that dietary methionine restriction extends the lifespan of rodents. However, the underlying mechanisms are incompletely understood.
Albertini, Eva, Koziel, Rafal, Dürr, Angela, Neuhaus, Michael, Jansen-Dürr, Pidder   +4 more
openaire   +3 more sources

In Situ Synthesis of a Tumor Microenvironment‐Activated Radiosensitizing Cu2‐xS/LDH Probe for Photoacoustic Imaging‐Guided Radiotherapy

Advanced Science, EarlyView.
We reported a new kind of organic‐inorganic composite nanomaterial with excellent PA imaging performance after the in situ activation by hydrogen sulfide in colorectal cancer tissues, which was used for precise radiotherapy of colorectal cancer. It shows a great application potential for early diagnosis and treatment of tumor.
Kang Zhu, Qiaoqiao Wei, Ying Wu, Qingqing Li, Luntao Liu, Chunxiang Mo, Chuqiao Liu, Lichao Su, Jibin Song   +8 more
wiley   +1 more source

Genotypic Spectrum in a Cohort of Sri Lankan Patients With Homocystinuria

JIMD Reports
Homocystinuria due to cystathionine beta‐synthase (CBS) deficiency is a rare metabolic disorder inherited as an autosomal recessive trait. Spectrum of genetic variants in CBS gene and their correlation with the phenotypes of homocystinuria in Sri Lankan ...
Hewa Warawitage Dilanthi, Kandana Liyanage Subhashinie Jayasena, Nambage Dona Priyani Dhammika, Neluwa Liyanage Ruwan Indika, Matara Mahavidanage Nishani De Silva, Imalke Kankananarachchi, Pushpa Malkanthi Gardiye Punchihewa, Dharma Irugalbandara, Sabine Schroeder, Kosala Karunaratne, Eresha Jasinge   +10 more
doaj   +1 more source

Volatile Sulfur Compounds as a Predictor for Esophagogastroduodenal Mucosal Injury

Gut and Liver, 2008
Background/Aims: Halitosis is a symptom that bothers patients more socially than medically and its pathogenic mechanisms are unclear and treatment armamenterium is limited. Clinicians generally ignored active interventions.
doaj   +1 more source

Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles [PDF]

, 2013
Background: Genome-wide association studies (GWAS) have identified many common single nucleotide polymorphisms (SNPs) that associate with clinical phenotypes, but these SNPs usually explain just a small part of the heritability and have relatively modest
Adamski, J. (Jerzy), Aulchenko, Y.S. (Yurii), Axenovich, T.I. (Tatiana), Biloglav, Z. (Zrinka), Broer, L. (Linda), Campbell, H. (Harry), Campbell, S. (Susan), Demirkan, A. (Ayşe), Dharuri, H. (Harish), Domingues, I. (Inês), Duijn, C.M. (Cornelia) van, Floyd, J. (Jamie), Franke, L. (Lude), Franklin, C.S. (Christopher), Gieger, C. (Christian), Gnewuch, C. (Carsten), Gyllensten, U. (Ulf), Hastie, N. (Nick), Hayward, C. (Caroline), Henneman, P. (Peter), Hettne, K.M. (Kristina), Hicks, A.A. (Andrew), Hoen, P.A.C. (Peter) 't, Hofman, A. (Albert), Huffman, J.E. (Jennifer), Igl, W. (Wilmar), Isaacs, A.J. (Aaron), Jansen, R.C. (Ritsert), Janssens, A.C.J.W. (Cécile), Johansson, A. (Åsa), Jonasson, I. (Inger), Karssen, L.C. (Lennart), Kirichenko, A.V. (Anatoly), Klinken, J.B. (Jan) van, Kolcic, I. (Ivana), Liebisch, G. (Gerhard), Meitinger, T. (Thomas), Mook-Kanamori, D.O. (Dennis), Oostra, B.A. (Ben), Pattaro, C. (Cristian), Pfeufer, A. (Arne), Pichler, I. (Irene), Polasek, O. (Ozren), Pramstaller, P.P. (Peter Paul), Rivadeneira Ramirez, F. (Fernando), Roos, M. (Marco), Rudan, I. (Igor), Schmitz, G. (Gerd), Struchalin, M.V. (Maksim), Suhre, K. (Karsten), Ugocsai, P. (Peter), Uitterlinden, A.G. (André), Vitart, V. (Veronique), Wang-Sattler, R. (Rui), Wild, S.H. (Sarah), Willems van Dijk, J.A.P. (Ko), Wilson, J.F. (James F), Witteman, J.C.M. (Jacqueline), Wright, A.F. (Alan), Zaboli, G. (Ghazal), Zorkoltseva, I.V. (Irina)   +60 more
core   +1 more source

Quantification of Single‐Cell Cysteine Using an Electrochemical Nanosensor for Predicting Tumor Disulfidptosis Susceptibility

Advanced Science, EarlyView.
Cysteine attracts interest due to its unique electrochemical activity and emerging relationship with disulfidptosis. This study develops a new electrochemical nanosensor, which represents the first of its kind capable of detecting intracellular cysteine for various types of tumor cells and primary tumor cells in mice to evaluate disulfidptosis ...
Congcong Zhang, Xiangdi Zhang, Shushen Li, Yuyang Li, Bei Yuan, Mingshuang Zheng, Shuo Zhang, Fangping Yuan, Min Jia, Lixia Lu, Jun Zhou, Zhenguo Zhang, Xin Du   +12 more
wiley   +1 more source

Contribution of hydrogen sulfide to the control of coronary blood flow [PDF]

, 2014
This study examined the mechanisms by which H2S modulates coronary microvascular resistance and myocardial perfusion at rest and in response to cardiac ischemia. Experiments were conducted in isolated coronary arteries and in open-chest anesthetized dogs.
Berwick, Zachary C., Casalini, Eli D., Goodwill, Adam G., Moberly, Steven P., Owen, Meredith K., Tune, Johnathan D.   +5 more
core   +1 more source