Results 161 to 170 of about 55,204 (241)

Use of adjunctive glycaemic agents with vascular protective properties in individuals with type 1 diabetes: Potential benefits and risks

Diabetes, Obesity and Metabolism, Volume 27, Issue 6, Page 2920-2939, June 2025.
Abstract Glycaemic therapy in type 1 diabetes (T1D) is focused on insulin, with the majority of studies investigating different insulin preparations, delivery devices and dosing accuracy methods. While insulin deficiency is the key mechanism for hyperglycaemia in T1D, individuals with this condition can also develop insulin resistance (IR), making ...
Ahmad M. Rajab, Sam Pearson, Ramzi A. Ajjan   +2 more
wiley   +1 more source

Metabolic Dysfunction‐Associated Steatotic Liver Disease Is Associated With Accelerated Brain Ageing: A Population‐Based Study

Liver International, Volume 45, Issue 6, June 2025.
ABSTRACT Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) is linked to cognitive decline and dementia risk. We aimed to investigate the association between MASLD and brain ageing and explore the role of low‐grade inflammation. Methods Within the UK Biobank, 30 386 chronic neurological disorders‐free participants who underwent
Jiao Wang, Rongrong Yang, Yuyang Miao, Xinjie Zhang, Stéphanie Paillard‐Borg, Zhongze Fang, Weili Xu   +6 more
wiley   +1 more source

Plasminogen Activator Inhibitor 1 Controls Abdominal Aortic Aneurism Formation via the Modulation of TGF‐β/Smad2/3 Signaling in Mice

The FASEB Journal, Volume 39, Issue 9, 15 May 2025.
Graphical illustration of the mechanism underlying the acceleration of plasminogen activator inhibitor1 deletion‐mediated abdominal aneurysm formation in mice undergoing calcium chloride2 induction surgery. Genetic intervention targeted toward plasminogen activator inhibitor1 accelerated AAA formation via the modulation of TGF‐β/Smad2/3 signaling in ...
Mantong Zhao, Lina Hu, Zhuo Lin, Xueling Yue, Xintong Zheng, Meiling Piao, Xianglan Jin, Limei Piao, Rihua Cui, Meilan Liu, Xian Wu Cheng   +10 more
wiley   +1 more source

Estimation of kidney function in Graves' disease using creatinine and cystatin C. [PDF]

Endocr Connect
Abbaszadeh S, Lundqvist MH, Ljunggren Ö, Larsson AO, Svensson MK, Khamisi S.   +5 more
europepmc   +1 more source

Advanced Materials for Biological Field‐Effect Transistors (Bio‐FETs) in Precision Healthcare and Biosensing

Advanced Healthcare Materials, Volume 14, Issue 13, May 16, 2025.
This review explores how advanced materials enhance Bio‐FETs for precision healthcare and biosensing. It covers their working principles, surface functionalization, and ultra‐sensitive detection capabilities. The integration of flexible designs, AI, and IoT for real‐time monitoring is discussed, along with challenges like material reproducibility and ...
Minal Pandey, Manish Bhaiyya, Prakash Rewatkar, Jitendra B. Zalke, Nitin P. Narkhede, Hossam Haick   +5 more
wiley   +1 more source

The kidney and the elderly : assessment of renal function ; prognosis following renal failure [PDF]

, 2003
Van Den Noortgate, Nele
core   +1 more source

Autophagy Related 5 Promotes Mitochondrial Fission and Inflammation via HSP90‐HIF‐1α‐Mediated Glycolysis in Kidney Fibrosis

Advanced Science, Volume 12, Issue 17, May 8, 2025.
When the normal kidney is subjected to injurious stimuli, it can lead to persistent activation of ATG5. The activation of ATG5 promotes HSP90‐HIF‐1α interaction, resulting in stabilization of HIF‐1α and subsequent activation of glycolysis. Consequently, this process contributes to mitochondrial fission and inflammation, ultimately culminating in kidney
Yan Hu, Jinqing Li, Hui Chen, Yingfeng Shi, Xiaoyan Ma, Yi Wang, Xialin Li, Qin Zhong, Yishu Wang, Daofang Jiang, Shougang Zhuang, Na Liu   +11 more
wiley   +1 more source

Salmonella Typhi serine threonine kinase T4519 induces lysosomal membrane permeabilization by manipulating Toll-like receptor 2-Cystatin B-Cathepsin B-NF-κB-reactive oxygen species pathway and promotes survival within human macrophages. [PDF]

PLoS Pathog
Chakraborty S, Ganguli D, Nagaraja T, Gope A, Dey S, Pal A, Mandal RS, Das SS, Das S.   +8 more
europepmc   +1 more source

Kinetic Redox Shotgun Proteomics Reveals Specific Lipopolysaccharide Effects on Intestinal Epithelial Cells, Mitigated by a Mn Superoxide Dismutase Mimic

Angewandte Chemie, Volume 137, Issue 19, May 5, 2025.
Proteomics and redoxomics are efficient to quantify the effects of bacterial lipopolysaccharide in intestinal epithelial cells (HT29) at the proteome and at the Cys‐redoxome levels. Oxidative stress is the initial trigger of LPS leading to inflammation.
Martha Zoumpoulaki, Giovanni Chiappetta, Jean Bouvet, Namita‐Raju John, Gabrielle Schanne, Pauline Gehan, Samuel Diebolt, Shakir Shakir, Elodie Quévrain, Emilie Mathieu, Sylvie Demignot, Philippe Seksik, Nicolas Delsuc, Joelle Vinh, Clotilde Policar   +14 more
wiley   +1 more source

EIF2S1 in Urinary Extracellular Vesicles as a Novel Diagnostic Marker for Bladder Cancer

Cancer Medicine, Volume 14, Issue 10, May 2025.
We conducted a proteomic analysis of urinary extracellular vesicles (uEVs) to identify and validate new diagnostic markers for bladder cancer. Focusing on cytoplasmic EV proteins, we discovered EV‐EIF2S1 as a novel marker and demonstrated its crucial role in the growth and survival of bladder cancer.
Eisuke Tomiyama, Kazutoshi Fujita, Kyosuke Matsuzaki, Ryohei Narumi, Makoto Matsushita, Yujiro Hayashi, Mamoru Hashimoto, Taigo Kato, Koji Hatano, Atsunari Kawashima, Takafumi Minami, Tetsuya Takao, Shingo Takada, Hirotsugu Uemura, Jun Adachi, Takeshi Tomonaga, Norio Nonomura   +16 more
wiley   +1 more source