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Cystatin C in Cerebrovascular Disorders
Current Neurovascular Research, 2018Cystatin C (CysC), a cysteine protease inhibitor, has been widely proven to be a highly sensitive biomarker to predict the kidney function. The similarity of the renal and cerebral small vessels has awakened a surge of studies suggesting that CysC plays a key role in various cerebrovascular disorders.
Li Sun, Yaru Zhang
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The role of cystatin C in multiple myeloma
International Journal of Laboratory Hematology, 2021AbstractIntroductionRenal insufficiency is one of the common complications in multiple myeloma (MM) and an independent factor indicating a poor prognosis. Cystatin C (Cys C) is considered to be expected to replace creatinine to calculate glomerular filtration rate due to its own characteristics.
Jie Zhang +6 more
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Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2002
Clinical biochemists have long known the analytical and clinical limitations of creatinine and creatinine clearance measurement in the assessment of glomerular filtration rate (GFR). This background is reviewed in the article before assessing the utility of cystatin C, the most promising replacement biochemical marker yet identified.
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Clinical biochemists have long known the analytical and clinical limitations of creatinine and creatinine clearance measurement in the assessment of glomerular filtration rate (GFR). This background is reviewed in the article before assessing the utility of cystatin C, the most promising replacement biochemical marker yet identified.
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Assessment of cystatin C and cystatin C-based GFR formulas in reflux nephropathy
Journal of Pediatric Urology, 2014Early identification of reflux nephropathy (RN) could reduce the frequency of chronic kidney disease (CKD) caused by vesicoureteral reflux (VUR). We aimed to assess whether cystatin C has value for determining RN in children with VUR.Ninety-three children with VUR were classified into two groups according to the presence of renal parenchymal scarring ...
Yavuz S., Anarat A., Bayazit A.K.
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2015
Renal function is essential for homeostasis. The kidneys play important pleiotropic roles including removal of metabolic waste products and maintenance of water-electrolyte balance and blood pressure. Early diagnosis of renal dysfunction and institution of appropriate therapy are vital to survival.
Anna Tokarzewicz +2 more
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Renal function is essential for homeostasis. The kidneys play important pleiotropic roles including removal of metabolic waste products and maintenance of water-electrolyte balance and blood pressure. Early diagnosis of renal dysfunction and institution of appropriate therapy are vital to survival.
Anna Tokarzewicz +2 more
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No mutations in cystatin C gene in cerebral amyloid angiopathy with cystatin C deposition
Molecular and Chemical Neuropathology, 1998To investigate the relationship between cerebral amyloid angiopathy (CAA) and cystatin C, we studied five CAA patients on whose cerebral blood vessels colocalization of cystatin C and beta-protein was recognized immunohistochemically. One patient was suspected as familial CAA and the other patients were sporadic cases.
Nobuyuki Umegae +6 more
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Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis.
American Journal of Kidney Diseases, 2002BACKGROUND Serum cystatin C (Cys C) has been proposed as a simple, accurate, and rapid endogenous marker of glomerular filtration rate (GFR) in research and clinical practice. However, there are conflicting reports regarding the superiority of Cys C over
V. Dharnidharka +2 more
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Cystatin C reference values and aging
Clinical Biochemistry, 2006The aim of this study was to determine the reference values for serum cystatin C (CysC) with a particular focus on the effect of aging.The study was performed on a consecutive series of subjects (258 men and 396 women). Laboratory parameters and a detailed personal and family medical history were collected.CysC showed a significant correlation with age
Ognibene, Agostino +10 more
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Biological variation of cystatin C and creatinine
Scandinavian Journal of Clinical and Laboratory Investigation, 2009To evaluate the day-to-day biological variation of cystatin C in comparison with creatinine in healthy subjects and in patients with impaired renal function.Eight weekly morning blood samples were taken from 20 healthy subjects (13 females and 7 males, median age 44 years, range 25-61) and 19 patients with impaired renal function (8 females and 11 ...
Reinhard, Mark +2 more
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Improved immunoturbidimetric assay for cystatin C [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2001 An immunoturbidimetric assay for cystatin C was optimized with respect to assay imprecision. After investigating the optimum pH, polyethylene glycol concentration and specimen volume, two modifications were introduced: an increase in specimen volume to 25 µL; and an extension of the pre-incubation period to 240s.
J B J McGuire +3 more
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