Results 91 to 100 of about 25,803 (305)

Successful treatment of solar lentigines by topical application of stabilized cysteamine: A vehicle‐controlled, double‐blind randomized study

Health Science Reports
Background Solar lentigines are common hyperpigmented lesions typically appearing after 50 years of age and associated with negative psychological effects in affected individuals. Topical depigmenting products, such as hydroquinone and even the Kligman's
Nasrin Saki, Vahideh Modabber, Hengameh Kasraei, Behrooz Kasraee   +3 more
doaj   +1 more source

Cognitive functions and behavioural profiles in children with cystinosis treated with cysteamine and correlation with treatment duration

Middle East Current Psychiatry, 2022
Background Cystinosis is a rare autosomal recessive disease. Children with nephropathic cystinosis (NCTN) have evidence of intellectual dysfunction and behavioural abnormalities which are attributed to renal dysfunction, metabolic disarrangement, and ...
Fatma M. Atia, Weam Ryad Alfaleet, Somaya H. Shaheen, Neveen A. Soliman   +3 more
doaj   +1 more source

Cutting‐Edge Aptasensing Approaches for Electrochemical Detection of Exosomes Utilizing MXenes

ChemElectroChem, EarlyView.
This work notably summarizes research on 2D MXenes/MXene's‐hybrid‐based nanoplatforms patterned with aptamers as an alternative to antibodies affording highly sensitive and robust biosensing of exosomes as well as their efficient isolation. The exosomes are highlighted as a valuable source of biomarkers and with the immobilization approaches of ...
Andrej Vikartovský, Natália Košútová, Lenka Lorencová, Peter Kasák, Tomáš Bertók, Ján Tkáč   +5 more
wiley   +1 more source

Effect of melatonin and/or cysteamine on development and vitrification of buffalo embryos

Asian Pacific Journal of Reproduction, 2017
Objective: To assess the effects of melatonin and/or cysteamineon in vitro maturation, culturing and post-warming of buffalo embryos.Methods: Buffalo oocytes were classified into control, cysteamine (50 μM), melatonin (10 ng/mL) and cysteamine (50 μM ...
Mohamed MM El-Sokary, Mohamed El-Raey, Karima GhM Mahmoud, Mahmoud EA Abou El-Roos, Gamal MS Sosa   +4 more
doaj   +1 more source

A novel sustained‐release cysteamine bitartrate formulation for the treatment of cystinosis: Pharmacokinetics and safety in healthy male volunteers

Pharmacology Research & Perspectives, 2021
The strict intake regimen of cysteamine bitartrate formulations, associated with side effects, is a concern for the treatment compliance in cystinosis therapy.
Cécile L. Berends, Lisa Pagan, Michiel J. vanEsdonk, Naomi B. Klarenbeek, Kirsten R. Bergmann, Matthijs Moerland, Vincent van derWel, Saco J. deVisser, Hans Büller, Frans deLoos, Wouter S. deVries, Hans Waals, Leo G. J. deLeede, Jacobus Burggraaf, Ingrid M. C. Kamerling   +14 more
doaj   +1 more source

Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel [PDF]

, 2019
Pentameric ligand-gated ion channels (pLGICs) are essential determinants of synaptic transmission, and are modulated by specific lipids including anionic phospholipids.
Brannigan, Grace, Cheng, Wayland W.L., Hsu, Fong-Fu, Nimigean, Crina M, Petroff II, John T, Schmidpeter, Philipp A.M., Sharp, Liam, Tong, Ailing   +7 more
core   +1 more source

A Poly (β‐Amino Esters)‐Based Multicomponent Nanoparticle for Efficient mRNA Delivery to Acute Myeloid Leukemia Cells

ChemistryEurope, EarlyView.
A structurally engineered nonviral vector (poly (β‐amino esters)‐lipid‐palmitic anhydride nanoparticles) integrates a poly(β‐amino ester) core for mRNA binding, palmitic anhydride for enhancing cellular uptake, and cationic 1,2‐Dioleoyl‐3‐trimethylammonium‐propane lipid for endosomal disruption is developed, which achieves 64.4% transfection efficiency
Zheng Wang, Dehua Huang, Lanrong Wu, Yuheng Cao, Yejun Zhang, Chunyan Li, Jiang Jiang, Guangcun Chen, Qiangbin Wang   +8 more
wiley   +1 more source

Programmable Site‐Selectivity: pH‐Modulated Triazine–Thiol Exchange for Site‐ and Chemoselective Cysteine Labeling

ChemistryEurope, EarlyView.
A pH‐programmable site‐selective cysteine modification in peptides is reported using a triazine–thiol exchange, termed TriTEx. At acidic pH, internal cysteines are targeted while preserving N‐terminal sites; at neutral pH, N‐terminal cysteines are selectively modified via an irreversible S–N shift.
Katerina Gavriel, Daniel Deißenbeck, Thomas J. Rutjes, Daniëlle W. T. Geers, Jan Meisner, Kevin Neumann   +5 more
wiley   +1 more source

Improved method for the preparation of malonyl coenzyme A

Journal of Lipid Research, 1968
Malonyl coenzyme A is synthesized by transacylating S-malonyl-N-decanoyl cysteamine with coenzyme A. A simplified procedure for the preparation of S-malonyl-N-decanoyl cysteamine, using cysteamine as starting material, is described.
Hans Mohrhauer, Kirsten Christiansen, Minerva Gan, Manfred Deubig, Ralph T. Holman   +4 more
doaj  

Absence of a dose-rate effect in the transformation of C3H 10T1/2 cells by α-particles [PDF]

, 1987
The findings of Hill et al. (1984) on the greatly enhanced transformation frequencies at very low dose rates of fission neutrons induced us to perform an analogous study with -particles at comparable dose rates. Transformation frequencies were determined
Balcer-Kubiczek E.K., Barendsen G.W, Barendsen G.W., Borek C., Burch P.R.J., Elkind M.M., Hall E.J., Han A., Han A., Hill C.K., Hill C.K., Hill C.K., Lloyd E.L., Miller R.C., Miller R.C., Reznikoff C., Robertson J.B., Roos H., Rossi H.H., Terzaghi M., Yang T.   +20 more
core   +1 more source